Abacavir is a Medicine belongs to Antiviral group whose information about Brand can be referenced from   Book : Martindale    Page : 963   Edition : 38,

  ►   Brandname : Ziagen,Abamune,Abec,kivexa

  ►  Strength : Tablet with 300  Mg, Oral solution with 20  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 888   Edition : 38, Basic & Clinical pharmacology    Page : 888   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 951   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 HIV infection and AIDS Oral 600 mg Tablet o.d.

Ref :-  Book : Martindale    Page : 963   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 HIV infection =<3Month Oral 8 mg/kg Solution b.d.

Ref :- Book : Martindale    Page : 963   Edition : 38,
►  Side Effect : fatal hypersensitivity reactions, fever, Rashes, Cough, dyspnoea, lethargy, malaise, headache, myalgia, gastrointestinal disturbance, nausea, vomiting, diarrhea, abdominal pain, anaphylaxis, severe hypersensitivity reaction, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, Lactic acidosis, Pancreatitis, raised liver enzyme values,
Ref :-   Book : Martindale    Page : 951   Edition : 37,

►  Drug Interaction : Drug interaction of Abacavir is with Alcohol,  Methadone ,
Ref :-   Book : Martindale    Page : 963   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Abacavir increases the systemic clearance of oral methadone and patients should be monitored for signs of withdrawal symptoms. Use of alcohol with abacavir may result in decreased elimination of abacavir and consequent increases in exposure.,
Ref :-   Book : Martindale    Page : 963   Edition : 38,


►  Contraindication : stopped if hypersensitivity reactions occur, end-stage renal failure, moderate to severe hepatic impairment,
Ref :-   Book : Martindale    Page : 963   Edition : 38,
  ►  Mechanism of Action :   Abacavir is converted intracellularly in stages to its active form carbovir triphosphate. This halts the DNA synthesis of retroviruses, including HIV, through competitive inhibition of reverse transcriptase and incorporation into viral DNA.,
Ref :-   Book : Martindale    Page : 963   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Mulathi with Another pathway, Thyme with Another pathway, Oregano with Another pathway, Rosemary with Another pathwayAnother pathway, Rosemary with Another pathwayAnother pathway, Parsley with Another pathway, Tea tree oil with Another pathway, Coconut oil with Another pathway,

  ►  Pathway with its reference as follows :-
  • anti- viral effect due to Castarospermine --- ( Birla, D. (2015). Evaluation of Diuretic activity of Glycyrrhiza glabra Linn. in Experimental animals. INTERNATIONAL JOURNAL OF PHARMACY & LIFE SCIENCES, 6(7). )
  • Thyme rich in apigenin enhance the antiviral activity of aciclovir. --- (Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand )
  • Oregano rich in apigenin enhance the antiviral activity of aciclovir. --- (Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand )
  • Rosemary rich in apigenin enhance the antiviral activity of aciclovir . --- (Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand )
  • Rosemary rich in apigenin enhance the antiviral activity of aciclovir . --- (Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand )
  • Rosemary rich in apigenin enhance the antiviral activity of aciclovir . --- (Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand )
  • Rosemary rich in apigenin enhance the antiviral activity of aciclovir . --- (Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand )
  • Parsley rich in apigenin enhance the antiviral activity of aciclovir. --- (Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand )
  • Tea tree oil have antiviral property --- (https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20 )
  • lauric acid found in coconut oil have antiviral property . --- ( G, Mary. "Coconut: In Support Of Good Health In The 21St Century". Nutritional Sciences Division, Enig Associates (2017): n. pag. Print. )

  •   ►  URL -- http://www.ijplsjournal.com/issues%20PDF%20files/2015/July-2015/5.pdf, https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20, http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf, http://www.apccsec.org/apccsec/admin/files/11ENIG.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- with Dietary Substance is Drug Inhibitor,

      ►  Reference :-
  • YAHEYA, M. & ISMAIL, M. (2009). HERB-DRUG INTERACTIONS AND PATIENT COUNSELING. International Journal Of Pharmacy And Pharmaceutical Sciences, 1(1), 151-161.

  •   ►  URL -- http://www.ijppsjournal.com/Vol1Suppl1/262R.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- ST. JOHNS WORT(HYPERICUM PERFORATUM) with Herb reduce blood level of drug.,

      ►  Reference :-

  •   ►  URL -- ,

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 963   Edition : 38,


    ►    Plasma Half-life :   Min value :-   1.5 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 963   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA