Abatacept is a Medicine belongs to Disease modifying antirheumatic drug group whose information about Brand can be referenced from   Book : Martindale    Page : 16   Edition : 38,

  ►   Brandname : Orencia

  ►  Strength : Injection with 250  mg/vial,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 656   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV infusion, SC,
Reference :-   Book : Martindale    Page : 15   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Moderate to severe active rheumatoid arthritis IV infusion 750 mg Injection Given to patients weighing 60 kg to 100 kg over a period of 30 minutes.
2 Moderate to severe active rheumatoid arthritis IV infusion 1 gm Injection Given to patients weighing over 100 kg over a period of 30 minutes.
3 Moderate to severe active rheumatoid arthritis IV infusion 500 mg Injection Given to patients weighing less than 60 kg over a period of 30 minutes.

Ref :-  Book : Martindale    Page : 15   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Moderate to severe active rheumatoid arthritis 6 Year <6 Year >75 IV infusion 10 mg/kg Injection

Ref :- Book : Martindale    Page : 15   Edition : 38,
►  Side Effect : nausea, flushing, pruritus, Rashes, wheezing, headache, nasopharyngitis, dyspepsia, diarrhea, Dizziness, back pain, fatigue, Cough, hypertension, hypotension, paraesthesia, thrombocytopenia, leucopenia, Rare; anaphylaxis., ,
Ref :-   Book : Martindale    Page : 15   Edition : 37,

►  Drug Interaction : Drug interaction of Abatacept is with Live Vaccines, Immunosuppressants , TNF Inhibitors,  Anakinra , Rituximab, Infliximab, Acebutolol ,
Ref :-   Book : Martindale    Page : 15   Edition : 37, Basic & Clinical pharmacology    Page : 1   Edition : 1,


  ►    Mechanism of Drug Drug Interaction :  Live vaccines should not be given with abatacept, or within 3 months of stopping it, as its effect on vaccine efficacy or the risk of infection transmission is unknown. The use of TNF inhibitors with abatacept may increase the risk of serious infections; such combinations are not recommended. Many of the serious infections reported have occured in patients also receiving immunosuppresive therapy. Use with anakinra or rituximab is also not recommended because of insufficient evidence to assess safety,
Ref :-   Book : Martindale    Page : 15   Edition : 37,


►  Contraindication : Hypersensitivity,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 806   Edition : 3,
  ►  Mechanism of Action :   CTLA-4 analogues fused to an IgG1 constant region; by forming a complex with cell-surface B7 molecules, the drug prevent delivery of a costimulatory signal and the T cell develops anergy or undergoes apoptosis,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 806   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Fish with Another pathway,

  ►  Pathway with its reference as follows :-
  • Antirheumatoid arthritis due to having glucosamen . --- ( Jerosch, Jörg. "Effects Of Glucosamine And Chondroitin Sulfate On Cartilage Metabolism In OA: Outlook On Other Nutrient Partners Especially Omega-3 Fatty Acids". International Journal of Rheumatology 2011 (2011): 1-17. Web )

  •   ►  URL -- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150191/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- FOLIC ACID with Decrease in Nutrient Level,

      ►  Reference :-
  • Jerosch, Jörg. "Effects Of Glucosamine And Chondroitin Sulfate On Cartilage Metabolism In OA: Outlook On Other Nutrient Partners Especially Omega-3 Fatty Acids". International Journal of Rheumatology 2011 (2011): 1-17. Web.

  •   ►  URL -- https://www.ncbi.nlm.nih.gov/pubmed/10805043,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   NA


    ►    Plasma Half-life :
      Min value :-   13 days,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 16   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA