Abciximab is a Medicine belongs to Drugs used in disorder of coagulation group whose information about Brand can be referenced from   Book : Martindale    Page : 1282   Edition : 38,

  ►   Brandname : ReoPro

  ►  Strength : Injection with 2  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 617   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV,
Reference :-   Book : Martindale    Page : 1314   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Acute ischaemic complications IV bolus 250 microgram/kg Injection It is used as an adjunct to heparin and aspirin therapy for the prevention of acute ischaemic complications in patients undergoing percutaneous coronary interventions including angioplasty, atherectomy, and stenting.

Ref :-  Book : Martindale    Page : 1314   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : hypotension, nausea, vomiting, thrombocytopenia, back pain, chest pain, headache, haematoma, bradycardia, fever, cardiac tamponade, hypersensitivity reactions, bleeding,
Ref :-   Book : Martindale    Page : 1313   Edition : 37,

►  Drug Interaction : Drug interaction of Abciximab is with Anticoagulant , , Thrombolytics Drug ,  NA

  ►    Mechanism of Drug Drug Interaction :  There may be an increased risk of bleeding if abciximab is given with other drugs that affect bleeding, including anticoagulants, other antiplatelet drugs, or thrombolytics.,
Ref :-   Book : Martindale    Page : 1313   Edition : 37,


►  Contraindication : aneurysm, arteriovenous malformation, Intracerebral neoplasm, thrombocytopenia, Uncontrolled hypertension, history of stroke, those recently undergone major surgery, severe trauma, emergency surgery required, Severe hepatic impairment, increased risk of haemorrhage, active bleeding,
Ref :-   Book : Martindale    Page : 1313   Edition : 37,
  ►  Mechanism of Action :   Abciximab is the Fab fragment of the chimeric monoclonal antibody 7E3. It binds to the glycoprotein IIb/IIIa receptor on the surface of platelets. This prevents binding of fibrinogen, von Willebrand factor, and other adhesive molecules to the receptor sites and inhibits platelet aggregation.,
Ref :-   Book : Martindale    Page : 1313   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- beetroot with Another pathway, Garlic with Another pathway,

  ►  Pathway with its reference as follows :-
  • cardioprotective effect --- (PDR for Herbal medicines. (2000) (4th ed.). U.S )
  • Antiplatelet --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- VITAMIN K with Dietary Substance is Drug Enhancer,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- GINGER (ZINGIBER OFFICINALE) with an increased risk of bleeding when used in combination with anticoagulants or antiplatelet agents ,

      ►  Reference :-
  • sai, Hsin-Hui et al. "A Review Of Potential Harmful Interactions Between Anticoagulant/Antiplatelet Agents And Chinese Herbal Medicines". PLoS ONE 8.5 (2013): e64255. Web.

  •   ►  URL -- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650066/,

    ►   Route of Elimination :   NA


    ►    Plasma Half-life :   Min value :-   30 min,    Max value :-   NA
    Ref :-   Book : Goodman    Page : 870   Edition : 12,


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA