Acebutolol is a Medicine belongs to Beta Blockers group whose information about Brand can be referenced from   Book : Martindale    Page : 1322   Edition : 37,

  ►   Brandname : Sectral

  ►  Strength : Capsule with 200  Mg, Capsule with 400  Mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 189   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 1322   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 hypertension Oral 400 mg Capsule o.d.
2 Angina pectoris Oral 400 mg Capsule o.d.
3 Cardiac arrhythmias Oral 200 mg Capsule b.d.

Ref :-  Book : Martindale    Page : 1322   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : abdominal cramp, arthralgia, bradycardia, bronchospasm, coldness of the extremities, constipation, diarrhoea, exacerbation of psoriasis, excess sweating, fatigue, heart block, heart failure, hyperglycemia, hypoglycemia, hypotension, muscle cramps, myopathies, nausea, nonthrombocytopenic purpura, paraesthesia, reversible alopecia, Skin rashes, thrombocytopenia, transient eosinophilia, vomiting, coldness, pruritus, abrupt withdrawal of beta blocker may exacerbate angina and sudden death, pneumonitis, pleurisy, pulmonary fibrosis, amnesia, Dizziness, headache, nightmares, Sleep disturbances, Confusion, Depression, hallucinations, changes in blood concentrations of triglycerides and cholesterol,
Ref :-   Book : Martindale    Page : 1349   Edition : 37, Martindale    Page : 1319   Edition : 38,

►  Drug Interaction : Drug interaction of Acebutolol is with Barbiturates , NSAIDS, Antiarrhythmics, Calcium Channel Blockers , Oral Hypoglycemic Drugs,  Clonidine , Cimetidine , Hydralazine , Erythromycin , Fluvoxamine, Rifampicin , Labetalol , Propranolol , Timolol , Verapamil , Digoxin , Insulin , Epinephrine (adrenaline) ,
Ref :-   Book : Martindale    Page : 1321   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Drugs that cause hypotension such as aldesleukin and general anaesthetics also enhance the antihypertensive effects of beta blockers while other drugs, for example NSAIDs, antagonise the antihypertensive effects. Use of beta blockers with other cardiac depressants such as antiarrhythmics and rate-limiting calcium channel blockers can precipitate bradycardia and heart block; the combination of intravenous verapamil and beta blockers should especially be avoided. Beta blockers may potentiate bradycardia due to digoxin. Patients taking beta blockers may have an exaggerated hypertensive response to adrenaline, caused by unopposed alpha-mediated vasoconstriction, while the bronchodilator effects are inhibited; the response to adrenaline given for anaphylaxis may also be reduced in patients on long-term treatment with beta blockers. In diabetic patients beta blockers can reduce the response to insulin and oral hypoglycaemics through their effects on pancreatic beta receptors. Metabolism of some beta blockers can be increased by drugs such as barbiturates and rifampicin and decreased with drugs such as cimetidine, erythromycin, fluvoxamine, and hydralazine. Drugs that alter hepatic blood flow also affect metabolism of some beta blockers. For example, cimetidine and hydralazine decrease hepatic blood flow and this contributes to the decreased hepatic clearance seen with these drugs. Drugs that influence hepatic metabolism affect beta blockers that are extensively metabolised, such as labetalol, propranolol, and timolol.,
Ref :-   Book : Martindale    Page : 1321   Edition : 38,


►  Contraindication : Bronchospasm, cardiogenic shock, metabolic acidosis, phaeochromocytoma, second -or- third degree AV block, severe peripheral arterial disease, Sinus bradycardia, asthma, hypotension, Obstructive airway disease, uncontrolled heart failure,
Ref :-   Book : Martindale    Page : 1351   Edition : 37,
  ►  Mechanism of Action :   Acebutolol is a cardioselective beta blocker . It is reported to have some intrinsic sympathomimetic activity and membrane stabilising properties,
Ref :-   Book : Martindale    Page : 1321   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Sesame seed with same pathway,

  ►  Pathway with its reference as follows :-
  • Sesame Seeds work as beta- adrenergic blockers . --- ( Houston, M. (2013). Nutrition and Nutraceutical Supplements for the Treatment of Hypertension: Part III. J Clin Hypertens, 15(12), 931-937. )

  •   ►  URL -- https://www.ncbi.nlm.nih.gov/pubmed/24119210,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- BANANA with Beta adrenergic blocker blockers decrease the uptake of potassium from the blood into the cells,leading to excess potassium in the blood, a potantially dangerous condition known as hyperkalemia .People taking beta-blocker should therefore avoid taking pot, POTASSIUM with The drug Acebutolol is non selective beta blocker interact with some nutrients or food decreases the uptake of potassium from the blood into the cells, leading to excess potassium in the blood, a potentially dangerous condition known as hyperkalemia spe,

      ►  Reference :-
  • Gaby, A. (2016). A-Z Guide to Drug -Herb -Vitamin Interactions (2nd ed.). Alan R: Three river press .new york.
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- MULATHI with Increase blood pressure & avoided by those taking blood pressure drugs.,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,

    ►   Route of Elimination :   Renal, Biliary, Fecal,
    Ref :-   Book : Martindale    Page : 1289,1290   Edition : 38,


    ►    Plasma Half-life :   Min value :-   3 hours,    Max value :-   4 hours,
    Ref :-   Book : Martindale    Page : 1322   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   4 hours,
    Ref :-   Book : Martindale    Page : 1322   Edition : 37,