Aceclofenac is a Medicine belongs to Non Sterodial Anti- Inflammatory Drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 16   Edition : 38,    Page :   Edition : ,

  ►   Brandname : Aceclo,Preservex,Beofenac,Acenac P,Aceva SP,Zerodol,Zerodol P, Zerodol SP

  ►  Strength : Tablet with   ,

Reference of this Medicine for its Strength can be taken from   Book :    Page :    Edition : ,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 15   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Osteoarthritis Oral 100 mg b.d.
2 Rheumatoid arthritis Oral 100 mg b.d.
3 Ankylosing spondylitis Oral 100 mg b.d.

Ref :-  Book : Martindale    Page : 15   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
Precaution :- If a Patient is using 'Aceclofenac' drug in  acute kidney injury   disease, then Please be avoided .

Precaution :- If a Patient is using 'Aceclofenac' drug in  ACUTE VIRAL HEPATITIS  disease, then Please use with caution .

Precaution :- If a Patient is using 'Aceclofenac' drug in  PEPTIC ULCER DISEASE  disease, then Please do not use .

Precaution :- If a Patient is using 'Aceclofenac' drug in alcoholic cirrhosis disease, then Please Use with caution. Can precipitate liver injury.   if he ever suffered from ABDOMEN PAIN disease.
Precaution :- If a Patient is using 'Aceclofenac' drug in ABERRATIONS OF NORMAL DEVELOPMENT AND INVOLUTION disease, then Please   if he ever suffered from Arenaviridae * Bunyaviridea * Filoviridae * Flaviviridae disease.
►  Side Effect : gastrointestinal discomfort, nausea, diarrhea, headache, vertigo, Dizziness, Nervousness, tinnitus, anaemias, thrombocytopenia, neutropenia, eosinophilia, agranulocytosis, hypersenstivity, bronchospasm, angioedema, fever, , Peptic Ulceration, severe gastrointestinal bleeding, Depression, drowsiness, insomnia, Rashes,
Ref :-   Book : Martindale    Page : 15, 100   Edition : 37, Martindale    Page : 15,100   Edition : 37,    Page :    Edition : ,

►  Drug Interaction : Drug interaction of Aceclofenac is with sulfonylurea antidiabetic , , Cardiac Glycosides, , Angiotensin conveting enzyme inhibitors , Diuretic Agents , Potassium -Sparing Diuretics , Beta Blockers , Quinolones, Corticosteroid , selective serotonin reuptake inhibitors, V2-receptor antagonist , Alcohol, Bisphosphonates,  Methotrexate, Tacrolimus , Phenytoin , , Clopidogrel , Ticlopidine , Iloprost , Erlotinib, Sibutramine, Pentoxifylline , Mifepristone , Cyclosporine , Betamethasone , Venlafaxine , Zidovudine, Ritonavir,
Ref :-   Book : Martindale    Page : 103   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Interactions involving NSAIDs include enhancement of the effects of oral anticoagulants (especially by azapropazone and phenylbutazone) and increased plasma concentrations of lithium, methotrexate, and cardiac glycosides. The risk of nephrotoxicity may be increased if given with ACE inhibitors, ciclosporin, tacrolimus, or diuretics. There may also be an increased risk of hyperkalaemia with ACE inhibitors and some diuretics, including potassiumsparing diuretics. The antihypertensive effects of some antihypertensives including ACE inhibitors, beta blockers, and diuretics may be reduced. NSAIDs may increase the effects of phenytoin and sulfonylurea antidiabetics. The risk of gastrointestinal bleeding and ulceration associated with NSAIDs is increased when used with corticosteroids, the SSRIs, the SNRI venlafaxine, the antiplatelets clopidogrel and ticlopidine, iloprost, erlotinib, sibutramine, or, possibly, alcohol, bisphosphonates, or pentoxifylline. There may be an increased risk of haematotoxicity if zidovudine is used with NSAIDs. Ritonavir may increase the plasma concentrations of NSAIDs. Licensed product information for mifepristone advises of a theoretical risk that prostaglandin synthetase inhibition by NSAIDs or aspirin may alter the efficacy of mifepristone,
Ref :-   Book : Martindale    Page : 103   Edition : 37,


►  Contraindication : Cerebrovascular disease, severe heart failure, ischaemic heart disease, peptic ulcer disease, peripheral arterial disease, gastrointestinal bleeding, Angioedema, asthma, history of hypersensitivity reactions, rhinitis, urticaria,
Ref :-   Book : Martindale    Page : 102,103   Edition : 37,
  ►  Mechanism of Action :   Aceclofenac, a phenylacetic acid derivative, Non-selective NSAIDs inhibit both cyclo-oxygenase-1 (COX-1) and cyclo-oxygenase-2 (COX-2); the idea that inhibition of COX-1 is associated with adverse gastrointestinal effects while inhibition of COX-2 is associated with anti-inflammatory activity,
Ref :-   Book : Martindale    Page : 15,103   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Aloe vera with Another pathway,

  ►  Pathway with its reference as follows :-
  • anti-inflamatory --- (Kokate, C.K. and A.p. Purohit. Pharmacognosy. Nirali prakashan: Chennai, 2013. Print. )

  •   ►  URL -- http://www.pragationline.com/generalpages/BookDetails.aspx?SRNO=N1275,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- VITAMIN C with Dietary Substance is Drug Enhancer,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf ,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 15   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   4 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 15   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   3 hours,
    Ref :-   Book : Martindale    Page : 15   Edition : 37,