Acetazolamide is a Medicine belongs to Diuretic Agents group whose information about Brand can be referenced from   Book : Martindale    Page : 2003   Edition : 38,

  ►   Brandname : acetamide,Diamox,acetamin,Acemit

  ►  Strength : Tablet with 125  Mg, Tablet with 250  Mg, Capsule with 500  Mg, Injection with 500  Mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 269   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV, IM,
Reference :-   Book : Martindale    Page : 2038   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Diuresis Oral 250 375 mg Tablet o.d.
2 Glaucoma Oral 250 1000 mg Tablet Given daily in divided doses.
3 Epilepsy Oral 250 1000 mg Capsule Given daily in divided doses.
4 High altitude disorders Oral 500 1000 mg Tablet Given daily in divided doses.

Ref :-  Book : Martindale    Page : 2001   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Glaucoma 1 Month 12 Year Oral 5 mg/kg b.d.
2 Epilepsy >1Day 12 Year Oral 2.5 mg/kg b.d/t.i.d
3 Raised intracranial pressure 1 Month 12 Year 8 100 mg/kg

Ref :- Book : Martindale    Page : 2038   Edition : 37,
►  Side Effect : malaise, fatigue, Depression, excitement, headache, weight loss, gastrointestinal disturbance, drowsiness, paraesthesia, Numbness, tingling of the extremities, tingling of the face, electrolyte disturbances, hyponatraemia, hypocalcaemia, Crystalluria, renal calculi, Renal colic, hypersensitivity reactions, allergic skin reactions, fever, thirst, Dizziness, ataxia, irritability, Confusion, reduced libido, haematuria, glycosuria, renal failure, abnormal liver fuction tests, altered taste, transient myopia, tinnitus, renal lesions, loss of appetite, hearing disturbances, ,
Ref :-   Book : Martindale    Page : 2037   Edition : 37,    Page :    Edition : ,

►  Drug Interaction : Drug interaction of Acetazolamide is with Thiazide Diuretics , ,  Ephedrine , Amphetamine , Quinidine , Felbamate, Methenamine , Aspirin,
Ref :-   Book : Martindale    Page : 2038   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  By rendering the urine alkaline acetazolamide reduces the urinary excretion, and so may enhance the effects, of drugs such as amfetamines, ephedrine, and quinidine; conversely, urinary alkalinisation can reduce the effects of methenamine and its compounds. Acetazolamide may enhance antiepileptic-induced osteomalacia. Use of acetazolamide with aspirin may result in severe acidosis and increase CNS toxicity. Acetazolamide may affect fluid and electrolyte balance leading to interactions similar to those of the thiazide diuretics. Unlike thiazides, however, acetazolamide may increase the excretion of lithium.,
Ref :-   Book : Martindale    Page : 2002   Edition : 38,


►  Contraindication : Addison’s disease, adrenocortical insufficiency, renal impairment, sodium or potassium depletion, marked hepatic impairment, marked renal impairment, chronic angle-closure glaucoma, history of hypersensitivity to sulfonamides,
Ref :-   Book : Martindale    Page : 2037   Edition : 37,
  ►  Mechanism of Action :   Acetazolamide is an inhibitor of carbonic anhydrase with weak diuretic activity and is used mainly in the management of glaucoma. By inhibiting carbonic anhydrase in the eye acetazolamide decreases the formation of aqueous humour and so decreases intra-ocular pressure.,
Ref :-   Book : Martindale    Page : 2001   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Beet with Another pathway, Capsaicin with same pathway,

  ►  Pathway with its reference as follows :-
  • Diuretic properties --- (kokate, C. (2013). Pharmacognosy (4th ed.). Mumbai: Nirali Prakashan. )
  • Capsaicin activeconstitruent of capsicum act as carbonic anhydrase inhibitor. --- ( Reetesh, M. (2011). Medicinal plants used in the treatment of epilepsy. International Research Journal Of Pharmacy., 2(2), 32-39. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html, http://www.irjponline.com/admin/php/uploads/vol2-issue2/6.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- CALCIUM with Long-term develop below normal blood levels of calcium , which may be related to drug -induced vitamin -D deficiency. ., VITAMIN D with Long -term anti-convulsant treatment appears to interfere with vitamin D activity , which might lead to softening of bones . , FOLIC ACID with Reduces blood levels of folic acid dramatically increases homocysteine levels ., VITAMIN A with Long-term lowered blood level of vitamin A ., VITAMIN A with Decrease in Nutrient Level, VITAMIN B12 with Decrease in Nutrient Level, VITAMIN B6 with Decrease in Nutrient Level, IRON with Decrease in Nutrient Level,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf, http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- with Excessive potassium loss if they also regularly us., MULATHI I.E LICORICE with Increase blood pressure & avoided by those taking blood pressure drugs.,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- , https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,

    ►   Route of Elimination :   Renal, breast milk,
    Ref :-   Book : Martindale    Page : 2038   Edition : 37,


    ►    Plasma Half-life :   Min value :-   3 hours,    Max value :-   6 hours,
    Ref :-   Book : Martindale    Page : 2038   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 2038   Edition : 37,