Acetylcysteine (N-acetylcysteine) is a Medicine belongs to Mucolytics group whose information about Brand can be referenced from   Book : Martindale    Page : 1654   Edition : 38,    Page :   Edition : ,

  ►   Brandname : Cilol,Flumucil,Parvolex,Acetadote,Asixintai,Acemuc,Mucinac

  ►  Strength : Injection with   , Ear Drop with   , Solution with   , Inhalation Solution with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 1654   Edition : 38, Martindale    Page :    Edition : ,    Page :    Edition : ,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, Oral, Topical,
Reference :-   Book : Martindale    Page : 1652   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Paracetamol poisoning IV 150 mg/kg Injection Given in 200 mL of glucose 5% is given initially over 60 minutes,
2 Respiratory disorders Local 3 5 ml nebuliser t.i.d. Given when disorders associated with productive cough.
3 Dry eye Topical 5 % Solution t.i.d/q.i.d Given as a 5% solution when dry eye is associated with abnormal mucus production.
4 Paracetamol poisoning Oral 140 mg/kg Solution Given as a 5% solution initially.

Ref :-  Book : Martindale    Page : 1652   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Paracetamol poisoning >20 IV infusion 150 mg/kg Injection
2 Paracetamol poisoning 20-40 IV infusion 150 mg/kg Injection
3 Respiratory disorders Local 3 5 ml nebuliser t.i.d/q.i.d
4 Dry eye Topical 5 % Eye Drop t.i.d/q.i.d

Ref :- Book : Martindale    Page : 1652   Edition : 38,
►  Side Effect : hypersensitivity reactions, bronchospasm, angioedema, pruritus, Rashes, hypotension, flushing, nausea, vomiting, fever, syncope, sweating, arthralgia, Blurred Vision, acidosis, convulsion, cardiac arrest, respiratory arrest , rhinorrhoea, stomatitis, Haemoptysis, occasional hypertension, hepatic function abnormalities,
Ref :-   Book : Martindale    Page : 1653   Edition : 38, Martindale    Page : 1653   Edition : 38,

►  Drug Interaction : Drug interaction of Acetylcysteine (N-acetylcysteine) is with NA

  ►    Mechanism of Drug Drug Interaction :  ,
Ref :-   Book :    Page :    Edition : ,


►  Contraindication : NA
  ►  Mechanism of Action :   Acetylcysteine is a mucolytic that reduces the viscosity of secretions probably by the splitting of disulfide bonds in mucoproteins.Acetylcysteine is also able to promote the detoxification of an intermediate paracetamol metabolite, and has a key role in the management of paracetamol overdosage.,
Ref :-   Book : Martindale    Page : 1652   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- with ,

  ►  Pathway with its reference as follows :-
  • hepatoprotective effect --- (Kokate, C.K. and A.p. Purohit. Pharmacognosy. Nirali prakashan: Chennai, 2013. Print. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 1654   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   6.25 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1654   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   0.5 hours,    Max value :-   1 hours,
    Ref :-   Book : Martindale    Page : 1654   Edition : 38,