Acetylcysteine (N-acetylcysteine) is a Medicine belongs to Mucolytics group whose information about Brand can be referenced from   Book : Martindale    Page : 1654   Edition : 38      Page :   Edition :   

  ►   Brandname : Cilol, Flumucil, Parvolex, Acetadote, Asixintai, Acemuc, Mucinac
  ►  Strength : Injection with .  Ear Drop with .  Solution with .  Inhalation Solution with

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 1654   Edition : 38   Martindale    Page :    Edition :       Page :    Edition :   
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, Oral, Topical
Reference :-   Book : Martindale    Page : 1652   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Paracetamol poisoning IV 150 mg/kg Injection Given in 200 mL of glucose 5% is given initially over 60 minutes,
2 Respiratory disorders Local 3 5 ml nebuliser t.i.d. Given when disorders associated with productive cough.
3 Dry eye Topical 5 % Solution t.i.d/q.i.d Given as a 5% solution when dry eye is associated with abnormal mucus production.
4 Paracetamol poisoning Oral 140 mg/kg Solution Given as a 5% solution initially.

Ref :-  Book : Martindale    Page : 1652   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Paracetamol poisoning >20 IV infusion 150 mg/kg Injection
2 Paracetamol poisoning 20-40 IV infusion 150 mg/kg Injection
3 Respiratory disorders Local 3 5 ml nebuliser t.i.d/q.i.d
4 Dry eye Topical 5 % Eye Drop t.i.d/q.i.d

Ref :- Book : Martindale    Page : 1652   Edition : 38  
►  Side Effect : Bronchospasm, Angioedema, pruritus, Rashes, Hypotension, Flushing, Nausea, Vomiting, Fever, Syncope, Sweating, Arthralgia, Blurred Vision, Acidosis, Convulsion, Cardiac arrest, Respiratory arrest , Rhinorrhoea, Stomatitis, Haemoptysis, Occasional hypertension, Hepatic function abnormalities
Ref :-   Book : Martindale    Page : 1653   Edition : 38.   Martindale    Page : 1653   Edition : 38.  

►  Drug Interaction : Drug interaction of Acetylcysteine (N-acetylcysteine) is with NA

  ►    Mechanism of Drug Drug Interaction : 
Ref :-   Book :    Page :    Edition : .  


►  Contraindication : NA
  ►  Mechanism of Action :   Acetylcysteine is a mucolytic that reduces the viscosity of secretions probably by the splitting of disulfide bonds in mucoproteins.Acetylcysteine is also able to promote the detoxification of an intermediate paracetamol metabolite, and has a key role in the management of paracetamol overdosage.
Ref :-   Book : Martindale    Page : 1652   Edition : 38.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication DIETARY Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Hepatic (Metabolism), Renal
Ref :-   Book : Martindale    Page : 1654   Edition : 38.  

►    Plasma Half-life :   Min value :-   6.25 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 1654   Edition : 38.  

►    Peak Plasma Concentration :   Min value :-   0.5 hours,    Max value :-   1 hours.  
Ref :-   Book : Martindale    Page : 1654   Edition : 38.