Aciclovir is a Medicine belongs to Antiviral group whose information about Brand can be referenced from   Book : Martindale    Page : 964   Edition : 38,

  ►   Brandname : Aciv,Acivir,Clearsore,Zovirax

  ►  Strength : Capsule with 200  Mg, Tablet with 400  Mg, Tablet with 800  Mg, Suspension with 200  Mg, Injection with 50  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 888   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, Topical, IV,
Reference :-   Book : Martindale    Page : 964   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Herpes simplex infections IV 5 mg/kg Injection t.i.d. Given to the immunocompromised patients for 5 to 7 days.
2 Varicella-zoster infections IV 5 mg/kg t.i.d. Given to Immunocompetent patients.
3 Varicella-zoster infections IV 10 mg/kg t.i.d. Given to the immunocompromised patients.
4 Chickenpox Oral 800 mg Tablet given four or five times daily for 5 to 7 days.
5 Herpes simplex infections of the skin Topical 5 % Cream including genital herpes and herpes labialis; applied 5 or 6 times daily.
6 Herpes simplex encephalitis IV 10 mg/kg Injection t.i.d. Given to the immunocompromised patients usually for 10 days.
7 Recurrent herpes labialis in immunocompetent patients Local 50 mg Tablet Given as a mucoadhesive buccal tablet.
8 Herpes simplex keratitis Topical 3 % Eye ointment Applied 5 times daily until 3 days after healing.
9 Acute Viral Meningitis IV 15 30 mg/kg Injection Given daily in three divided dose.
10 Herpes simplex infections Oral 200 mg Capsule Given 5 times daily for 5 to 10 days.
11 Suppression of recurrent herpes simplex in immunocompetent patients Oral 800 mg Tablet Given daily in 2 to 4 div doses.
12 Prophylaxis of herpes simplex in immunocompromised patients Oral 200 400 mg Tablet q.i.d.
13 Herpes simplex encephalitis Dosing In Obesity: Use Adjusted BW Example: For Herpes simplex encephalitis, give 10 mg/kg of Adjusted BW every 8 hr. Ref: The Sanford Guide To Antimicrobial Therapy, pg 231,232 ed. 47th
14 Herpes simplex encephalitis Dosing In Obesity: Use Adjusted BW Example: For herpes simplex encephalitis, give 10 mg/kg of Adjusted BW every 8 hr. Ref: The Sanford Guide To Antimicrobial Therapy, pg 231,232 ed. 47th

Ref :-  Book : Martindale    Page : 964   Edition : 38, Harrison's principles of internal medicine    Page : 3420   Edition : 18,    Page :    Edition : ,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Gingivostomatitis Oral 15 mg/kg/dose Tablet
2 Genital Herpes Oral 400 mg Tablet t.i.d.
3 Herpes labialis 10 Year 19 Year Oral 200 400 mg Tablet
4 Herpes gladiatorum 10 Year 19 Year Oral 200 mg Tablet
5 Herpes simplex encephalitis 3Month 12Year IV 20 mg/kg Injection t.i.d.
6 Severe mucocutaneous and disseminated HSV infections IV 5 10 mg/kg Injection t.i.d.
7 Neonatal HSV infection >1 Day <4 Week IV 60 mg/kg/day Injection
8 Varicella-zoster infections 3Month 12Year IV 20 mg/kg Injection t.i.d.

Ref :- Book : Nelson's textbook of Pediatrics    Page : 1102   Edition : 19, Nelson's textbook of Pediatrics    Page : 1103   Edition : 19, Martindale    Page : 964   Edition : 38,
Precaution :- If a Patient is using 'Aciclovir' drug in  Generalized, Tonic-Clonic Seizures  disease, then Please Not to be given .

Precaution :- If a Patient is using 'Aciclovir' drug in  Herpes Simplex  disease, then Please Contraindication- Hypersensitivity .

Precaution :- If a Patient is using 'Aciclovir' drug in  Herpes Simplex  disease, then Please Caution- Renal failure .

Precaution :- If a Patient is using 'Aciclovir' drug in  Herpes Simplex  disease, then Please Caution- TTP and Hemolytic uremic syndrome .

Precaution :- If a Patient is using 'Aciclovir' drug in  Herpes Simplex  disease, then Please Lactation- Drug enters breast milk; use with caution. .

►  Side Effect : nausea, diarrhea, headache, interstitial nephritis, crystalline nephropathy, tremor, delirium, seizure, Rashes, diaphoresis, hypotension, , altered sensorium, myoclonus, extrapyramidal symptoms,
Ref :-   Book : Goodman    Page : 1598-1599   Edition : 12,    Page :    Edition : ,

►  Drug Interaction : Drug interaction of Aciclovir is with Nephrotoxic drugs,  Probenecid ,
Ref :-   Book : Martindale    Page : 966   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Probenecid is reported to block the renal clearance of aciclovir. The risk of renal impairment is increased by use with other nephrotoxic drugs,
Ref :-   Book : Martindale    Page : 964   Edition : 38,


►  Contraindication : Hypersensitivity to acyclovir, Hypersensitivity to valacyclovir,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 670   Edition : 3,
  ►  Mechanism of Action :   Acyclovir inhibits viral DNA synthesis. Its selectivity of action depends on interaction with two distinct viral proteins: HSV thymidine kinase and DNA polymerase. ,
Ref :-   Book : Goodman    Page : 1594   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Tea tree oil with Another pathwayAnother pathway, Tea tree oil with Another pathwayAnother pathway, Ginger (Zingiber officinale) with Another pathway, Tulsi with Another pathway, Chammomila with Another pathway, Thyme with Another pathway, Oregano with Another pathway, Rosemary with Another pathway, Parsley with Another pathway, Quercetin with Another pathway, Broccoli( Cooked) with Another pathway, Vitamin A with Another pathway, Zinc with Another pathway, Evening primrose oil with Another pathway, Coconut oil with Another pathway,

  ►  Pathway with its reference as follows :-
  • terpinen-4-ol have antiviral effect --- (Kokate, c. & Purohit, A. (2016). pharmacognosy. nirali prakashan. )
  • Anti viral property due to Terpinen --- (Kokate, C.K. and A.p. Purohit. Pharmacognosy. Nirali prakashan: Chennai, 2013. Print. )
  • terpinen-4-ol have antiviral effect --- (Kokate, c. & Purohit, A. (2016). pharmacognosy. nirali prakashan. )
  • Anti viral property due to Terpinen --- (Kokate, C.K. and A.p. Purohit. Pharmacognosy. Nirali prakashan: Chennai, 2013. Print. )
  • Citrusunine-1 have Anti viral property --- (Chang, J., Wang, K., Yeh, C., Shieh, D., & Chiang, L. (2013). Fresh ginger (Zingiber officinale) has anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines. Journal Of Ethnopharmacology, 145(1), 146-151. )
  • Tulsi rich in apigenin enhance the antiviral activity of aciclovir. --- (Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press )
  • Chammomila rich in apigenin enhance the antiviral activity of aciclovir --- (Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press )
  • Thyme rich in apigenin enhance the antiviral activity of aciclovir. --- (Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press )
  • Oregano rich in apigenin enhance the antiviral activity of aciclovir. --- (Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press )
  • Rosemary rich in apigenin enhance the antiviral activity of aciclovir . --- (Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press )
  • Parsley rich in apigenin enhance the antiviral activity of aciclovir. --- (Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press )
  • Quercetin enhance the antiviral activity of aciclovir. --- (Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press )
  • Broccoli rich in apigenin enhance the antiviral activity of aciclovir. --- (Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press )
  • Vit A has strong antiviral activity. --- (Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand )
  • Zinc help in destroying viral infection. --- (Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand )
  • Act as nerve stimulant . --- (Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand )
  • lauric acid found in coconut oil have antiviral property . --- (G, Mary. "Coconut: In Support Of Good Health In The 21St Century". Nutritional Sciences Division, Enig Associates (2017): n. pag. Print. )

  •   ►  URL -- https://www.sapnaonline.com/books/pharmacognosy-ck-kokate-8196396155-9788196396152, http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html, http://www.ncbi.nlm.nih.gov/pubmed/23123794, New York: Three Rivers Press http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf, http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf, https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20, http://www.apccsec.org/apccsec/admin/files/11ENIG.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- FLAVONOID with The flavonoids quercetin , quercitrin , and apigenin enhanced the antiviral of acyclovir ,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- CITRUS ROOT BARK with The alkaloid citrusinine-1 from the root bark of citrus plants has been shown to enhance the antiviral activity of acyclovir . ,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,

    ►   Route of Elimination :   Fecal, Renal,
    Ref :-   Book : Martindale    Page : 966   Edition : 38,


    ►    Plasma Half-life :   Min value :-   1.5 hours,    Max value :-   6 hours,
    Ref :-   Book : Goodman    Page : 1597   Edition : 12,


    ►    Peak Plasma Concentration :   Min value :-   8 hours,    Max value :-   NA
    Ref :-   Book : Goodman    Page : 1597   Edition : 12,