Adalimumab is a Medicine belongs to Disease modifying antirheumatic drug group whose information about Brand can be referenced from   Book : Martindale    Page : 17   Edition : 37,

  ►   Brandname : Humira

  ►  Strength : Injection with 20,40  mg/vial,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 999   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : SC,
Reference :-   Book : Martindale    Page : 16   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Ankylosing spondylitis SC 40 mg Injection Given every other week.
2 Plaque psoriasis SC 80 mg
3 Crohn’s disease SC 160 mg Injection Given for moderate to severe active disease; as four 40-mg injections in one day or two 40-mg injections daily for 2 consecutive days.
4 Rheumatoid arthritis SC 40 mg Injection Given for moderate to severe active disease; every other week.
5 Psoriatic arthritis SC 40 mg Injection Given for active and progressive disease; on every other week.

Ref :-  Book : Martindale    Page : 16   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Active juvenile idiopathic arthritis 4Year 17Year 15 - 30 SC 20 mg Injection
2 Active juvenile idiopathic arthritis 4Year 17Year <30 SC 40 mg Injection

Ref :- Book : Martindale    Page : 16   Edition : 37,
►  Side Effect : vomiting, abdominal pain, diarrhea, fatigue, Dizziness, headache, back pain, hypertension, paraesthesia, Cough, lupus-like syndrome, opportunistic infections, sepsis, pneumonia, blood dyscrasias, leucopenia, thrombocythaemia, pancytopenia, aplastic anaemia, anaphylactic reactions, onset or reactivation of tuberculosis, increased alkaline phosphate levels, fever, chills, pruritus, Urticaria, Urticaria, dyspnoea, chest pain, hypotension,
Ref :-   Book : Martindale    Page : 16, 72   Edition : 37, Martindale    Page : 16,72   Edition : 37,

►  Drug Interaction : Drug interaction of Adalimumab is with Live Vaccines,  Anakinra , Abatacept , Methotrexate,
Ref :-   Book : Martindale    Page : 16   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  The use of TNF inhibitors with the interleukin-1 receptor antagonist anakinra may increase the risk of serious infections and neutropenia; such combinations are not recommended. A similar interaction has been seen with TNF inhibitors and the co-stimulation blocker abatacept. Methotrexate is reported to reduce the clearance of adalimumab by up to 44% but licensed product information for the latter states that dosage adjustment for either drug does not appear to be necessary. Live vaccines should not be given with infliximab or other drugs that inhibit TNF as the effect of such drugs on vaccine efficacy or the risk of infection transmission is unknown.,
Ref :-   Book : Martindale    Page : 74,16   Edition : 37,


►  Contraindication : cardiac tamponade, Chronic infections, latent tuberculosis,
Ref :-   Book : Martindale    Page : 72   Edition : 37,
  ►  Mechanism of Action :   Adalimumab is a recombinant human monoclonal tumour necrosis factor (TNF) antibody that binds specifically to TNF-α and blocks its interaction with endogenous cell-surface TNF receptors. It also modulates biological responses that are induced or regulated by TNF. ,
Ref :-   Book : Martindale    Page : 16   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Aloe vera with Another pathway,

  ►  Pathway with its reference as follows :-
  • Anti inflammatroy property --- (Kokate, C.K. and A.p. Purohit. Pharmacognosy. Nirali prakashan: Chennai, 2013. Print. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- with aloe is contraindicated in case of intertinal obstruction ,acutely inflamed intestinal diseases,appendicitis & abdominal pain .muak,

      ►  Reference :-
  • PDR for Herbal medicines. (2000) (4th ed.). U.S.

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,

    ►   Route of Elimination :   NA


    ►    Plasma Half-life :   Min value :-   2 weeks,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 16   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   3 days,    Max value :-   8 days,
    Ref :-   Book : Martindale    Page : 16   Edition : 37,