Adapalene is a Medicine belongs to Dermatological drug group whose information about Brand can be referenced from   Book : Martindale    Page : 1692   Edition : 38,

  ►   Brandname : Aclene,Adaferin,Differin

  ►  Strength : Solution with   , Cream with   , Gel with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 1692   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Topical,
Reference :-   Book : Martindale    Page : 1692   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Acne Topical 0.1 % Solution o.d. It is applied at night; also available as cream, or gel.

Ref :-  Book : Martindale    Page : 1692   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Neonatal and infantile acne Topical 0.1 % Cream o.d.

Ref :- Book : Martindale    Page : 1692   Edition : 38,
►  Side Effect : transitory stinging, feeling of warmth, erythema, Dryness, pruritus, peeling, oedema, Blistering, crusting of the skin, Severe erythema, photosensitivity, temporary hypopigmentation, hyperpigmentation, Arrhythmias, flushing, hypotension, hypertension, heart failure, cardiac arrest, myocardial infarction, cardiomegaly, heart murmur, ischaemia, stroke, myocarditis, pericarditis, pulmonary hypertension, secondary cardiomyopathy, retinoic acid syndrome, Skin irritant,
Ref :-   Book : Martindale    Page : 1760   Edition : 37,

►  Drug Interaction : Drug interaction of Adapalene is with NA

  ►    Mechanism of Drug Drug Interaction :  ,
Ref :-   Book :    Page :    Edition : ,


►  Contraindication : abraded skin, sunburnt, eczematous,
Ref :-   Book : Martindale    Page : 1761   Edition : 37,
  ►  Mechanism of Action :   It appears to stimulate mitosis and turnover of follicular epithelial cells and reduce their cohesiveness thereby facilitating the extrusion of existing comedones and preventing the formation of new ones. ,
Ref :-   Book : Martindale    Page : 1761   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Neem with Another pathway,

  ►  Pathway with its reference as follows :-
  • Neem having active constituent nimbidin which act as ant-acne effect . --- ( Pratik M,, B., Ashok V, G., & Pranita A, G. (2014). A quest of Anti-acne Potential of Herbal Medicines for extermination of MDR Staphylococcus aureus. International Journal Of Pharmaceutical Science Invention, 3(6), 2319 – 6718. )

  •   ►  URL -- http://www.ijpsi.org/Papers/Vol3(6)/C0361012017.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   NA


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA