Adefovir dipivoxil is a Medicine belongs to Antiviral group whose information about Brand can be referenced from   Book : Martindale    Page : 967   Edition : 38,

  ►   Brandname : Hepsera,Adesera,Adfovir,A Di Xian

  ►  Strength : Tablet with 10  Mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 888   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Basic & Clinical pharmacology    Page : 888   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Chronic hepatitis B Oral 10 mg Tablet o.d.

Ref :-  Book : Martindale    Page : 967   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : nausea, Flatulence, diarrhea, dyspepsia, abdominal pain, headache, asthenia, pruritus, Skin rashes, raised liver enzyme values, acute exacerbation of hepatitis, ,
Ref :-   Book : Martindale    Page : 954   Edition : 37,    Page :    Edition : ,

►  Drug Interaction : Drug interaction of Adefovir dipivoxil is with , ,  NA

  ►    Mechanism of Drug Drug Interaction :  Caution should be exercised when adefovir is given with other drugs eliminated by active tubular secretion as competition for the elimination pathway may increase the serum concentrations of either drug. Care is required when adefovir is given with other drugs with the potential for nephrotoxicity.,
Ref :-   Book : Martindale    Page : 954   Edition : 37,


►  Contraindication : metabolic or lactic acidosis of unknown aetiology, progressive hepatomegaly or steatosis, rapid increase in aminotransferase concentrations,
Ref :-   Book : Martindale    Page : 967   Edition : 38,
  ►  Mechanism of Action :   Adefovir is converted intracellularly in stages to the diphosphate, which then inhibits the DNA synthesis of hepatitis B virus through competitive inhibition of reverse transcriptase and incorporation into viral DNA.,
Ref :-   Book : Martindale    Page : 967   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- with Another pathway, Chicory with , Mulathi with Another pathway,

  ►  Pathway with its reference as follows :-
  • silymarin have antiviral effect --- (Lin, L., Hsu, W., & Lin, C. (2014). Antiviral Natural Products and Herbal Medicines. Journal Of Traditional And Complementary Medicine, 4(1), 24-35. http://dx.doi.org/10.4103/2225-4110.124335 )
  • inulin have antiviral property --- ( Duke, J. (2002). Handbook of medicinal herbs (2nd ed.). United stata of America: CRC press. )
  • glycyrrhizin have Anti viral effect. --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032839/, https://www.crcpress.com/Handbook-of-Medicinal-Herbs-Second-Edition/Duke/p/book/9780849312847, http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 954   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   7 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 954   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   0.6 hours,    Max value :-   4 hours,
    Ref :-   Book : Martindale    Page : 954   Edition : 37,