Alendronate/ Alendronic acid is a Medicine belongs to Bisphosphonates group whose information about Brand can be referenced from   Book : Martindale    Page : 1173   Edition : 38  

  ►   Brandname : Alenost, Bifosa, Fosamax, Adronat, Alendron, Anlun, Bonalon
  ►  Strength : Tablet with 5 Mg.  Tablet with 10 Mg.  Tablet with 35 Mg.  Tablet with 40 Mg.  Tablet with 70 Mg.  Solution with 70/75 mg/ml. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 786   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, Oral
Reference :-   Book : Martindale    Page : 1171,1172   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Osteoporosis Oral 10 mg Tablet o.d. For men.
2 Osteoporosis prophylaxis in postmenopausal women Oral 5 mg Tablet o.d.
3 Corticosteroid induced osteoporosis Oral 5 mg Tablet o.d.
4 Paget’s disease Oral 40 mg Tablet Given daily for 6 months.

Ref :-  Book : Martindale    Page : 1172   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Abdominal pain, Dyspepsia, Diarrhea, Constipation, Oesophagitis, Dysphagia, New or worsening heartburn, Peptic Ulceration, Erosions, Ulceration, Pain on swallowing, Retrosternal pain
Ref :-   Book : Martindale    Page : 1171   Edition : 38.  

►  Drug Interaction : Drug interaction of Alendronate/ Alendronic acid is with , Non Sterodial Anti- Inflammatory Drugs , AMINOGLYCOSIDES ,  Iron , Aluminium hydroxide
Ref :-   Book : Martindale    Page : 1177   Edition : 37.   Martindale    Page : 1177   Edition : 38.  


  ►    Mechanism of Drug Drug Interaction :  Compounds containing aluminium, calcium, iron, or magnesium, including antacids and mineral supplements and some osmotic laxatives, can also impair the absorption
Ref :-   Book : Martindale    Page : 1177   Edition : 38.  


►  Contraindication : Abnormalities of the oesophagus, Factors that might delay oesophageal emptying, Those unable to stand or sit upright for at least 30 minutes
Ref :-   Book : Martindale    Page : 1172   Edition : 38.  
  ►  Mechanism of Action :   Suppress the activity of osteoclasts in part via inhibition of farnesyl pyrophosphate synthesis.
Ref :-   Book : Basic & Clinical pharmacology    Page : 785   Edition : 12.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Soyabean with same compound.  

  ►  Pathway with its reference as follows :-
  • Soyabean having high Nitrogen content . --- (A.M., R. (2004). NITROGEN CONTENTS IN FOOD: A COMPARISON BETWEEN THE KJELDAHL AND HACH METHODS. J. Argent. Chem. Soc, 92(6), 99 - 108. )

  •   ►  URL --
  • http://www.scielo.org.ar/pdf/aaqa/v92n4-6/v92n4-6a11.pdf .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- CALCIUM with Dietary Substance is Drug Inhibitor.  

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf


    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal
    Ref :-   Book : Martindale    Page : 1173   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA