Aliskiren Fumarate is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1329   Edition : 37,

  ►   Brandname : Rasilez,Tekturna

  ►  Strength : Tablet with 150  Mg, Tablet with 300  Mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 190   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1329   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 hypertension Oral 150 mg Tablet o.d.

Ref :-  Book : Martindale    Page : 1295   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : diarrhea, abdominal pain, dyspepsia, gastro-oesophageal reflux, hypotension, headache, Dizziness, fatigue, back pain, Cough, Rashes, hyperuricaemia, renal calculi, Gout, hyperkalaemia, Stevens-Johnson syndrome, toxic epidermal necrolysis, pruritus, oral mucosal reactions, Urticaria, , decrease in haemoglobin,
Ref :-   Book : Martindale    Page : 1329   Edition : 37,    Page :    Edition : ,

►  Drug Interaction : Drug interaction of Aliskiren Fumarate is with Antihypertensive Agents , , Non Sterodial Anti- Inflammatory Drugs , Angiotensin conveting enzyme inhibitors ,  Irbesartan, Atorvastatin , Ketoconazole , Furosemide , Cyclosporine ,
Ref :-   Book : Martindale    Page : 1329   Edition : 37, Martindale    Page : 1329   Edition : ,    Page :    Edition : ,


  ►    Mechanism of Drug Drug Interaction :  Use of aliskiren with other antihypertensives or drugs that cause hypotension may have an additive effect. Renal function and electrolytes should be monitored in diabetic patients taking aliskiren and ACE inhibitors since there is an increased risk of hyperkalaemia and renal impairment. Aliskiren is a substrate for P-glycoprotein & should not be given with cyclosporine; a strong P-glycoprotein inhibitor. Aliskiren is metabolised to a small extent by the cytochrome P450 isoenzyme CYP3A4 but few significant interactions have been reported. Plasma-aliskiren concentrations may be reduced by irbesartan and increased by atorvastatin and ketoconazole but the clinical relevance is not clear. Aliskiren has caused significant decreases in furosemide concentration.,
Ref :-   Book : Martindale    Page : 1329   Edition : 37,


►  Contraindication : Pregnancy, cyclosporine therapy, hyperkalaemia, history of angioedema,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 349   Edition : 3,    Page :    Edition : ,
  ►  Mechanism of Action :   Inhibition of renin decreases conversion of angiotensinogen to angiotensin I, thereby reducing the substrate for ACE and decreasing subsequent arteriolar vasoconstriction, aldosterone synthesis, renal proximal tubule NaCl reabsorption, and ADH release.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 349   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Flaxseed with same pathway,

  ►  Pathway with its reference as follows :-
  • Flaxseed peptide fractions act as renin inhibitors . --- (Udenigwe, C., Lin, Y., Hou, W., & Aluko, R. (2009). Kinetics of the inhibition of renin and angiotensin I-converting enzyme by flaxseed protein hydrolysate fractions. Journal Of Functional Foods, 1(2), 199-207. doi:10.1016/j.jff.2009.01.009 )

  •   ►  URL -- http://www.sciencedirect.com/science/article/pii/S1756464609000103,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- MULATHI I.E LICORICE with Increase blood pressure & avoided by those taking blood pressure drugs.,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,

    ►   Route of Elimination :   Renal, Fecal,
    Ref :-   Book : Martindale    Page : 1329   Edition : 37,


    ►    Plasma Half-life :   Min value :-   24 hours,    Max value :-   40 hours,
    Ref :-   Book : Martindale    Page : 1329   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   3 hours,
    Ref :-   Book : Martindale    Page : 1329   Edition : 37,