Allopurinol is a Medicine belongs to Anti gout group whose information about Brand can be referenced from   Book : Martindale    Page : 603   Edition : 37,    Page :   Edition : ,

  ►   Brandname : Ciploric,Zyloric,Caplenal,Aloprim,Allosig,Allo

  ►  Strength : Oral Suspension with   , Tablet with 100  mg, Tablet with 300  mg, Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 602,603   Edition : 37, Basic & Clinical pharmacology    Page : 656   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 602   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Prevention of uric acid nephropathy Oral 600 800 mg Tablet Dose given daily; when this problem is associated with cancer therapy.
2 Renal calculi Oral 200 300 mg Tablet This daily dose recommended for the management of recurrent calcium oxalate renal calculi in patients with hyperuricosuria.

Ref :-  Book : Martindale    Page : 602   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Hyperuricaemia associated with cancer or cancer chemotherapy >15 Year Oral 10 20 mg/kg Oral Suspension
2 Hyperuricaemia associated with enzyme disorders >15 Year Oral 10 20 mg/kg Oral Suspension

Ref :- Book : Martindale    Page : 602   Edition : 37,
Precaution :- If a Patient is using 'Allopurinol' drug in acute kidney injury disease, then Please to be avoided   if he ever suffered from Gout disease.
►  Side Effect : agranulocytosis, aplastic anaemia, arthralgia, chills, eosinophilia, exfoliative rashes, fever, leucopenia, lymphadenopathy, maculopapular rash, pruritic skin rash, Stevens-Johnson syndrome, toxic epidermal necrolysis, vasculitis, haemolytic anaemia, hepatic toxicity, hepatocellular injury, renal damage, thrombocytopenia, Skin rashes, pruritus, severe hypersensitivity reaction, ,
Ref :-   Book : Martindale    Page : 600   Edition : 37,    Page :    Edition : ,

►  Drug Interaction : Drug interaction of Allopurinol is with Salicylates, Angiotensin conveting enzyme inhibitors , Thiazide Diuretics , Sodium channel blockers , ,  Aspirin, Azathioprine , Mercaptopurine, Cyclosporine , Theophylline , Vidarabine ,
Ref :-   Book : Martindale    Page : 601   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Drugs that can increase uric acid concentrations may decrease the efficacy of allopurinol. Aspirin and the salicylates possess this activity and should generally be avoided in hyperuricaemia and gout. An increase in hypersensitivity reactions, and possibly also other adverse effects, has been reported in patients taking allopurinol with ACE inhibitors or thiazide diuretics, particularly in patients with renal impairment. The metabolism of azathioprine and mercaptopurine is inhibited by allopurinol and their doses should be markedly reduced when either of them is given with allopurinol to avoid potentially life-threatening toxicity. There have also been reports of allopurinol enhancing the activity of, and possibly increasing the toxicity of, a number of other drugs including some antibacterials, some anticoagulants, some other antineoplastics, ciclosporin, some sulfonylurea antidiabetics, theophylline, and vidarabine. ,
Ref :-   Book : Martindale    Page : 601   Edition : 37,


►  Contraindication : Hypersensitivity, acute attacks of gout,
Ref :-   Book : Martindale    Page : 602   Edition : 38,
  ►  Mechanism of Action :   Alloprinol inhibits xanthine oxidase, the enzyme that converts xanthine and hypoxanthine to uric acid. ,
Ref :-   Book : Clinical Pharmacology    Page : 296   Edition : 9,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Tomatoes with same pathway, Lemon grass with same pathway, Apple with same pathway,

  ►  Pathway with its reference as follows :-
  • Xanthine oxidase inhibitor --- (Lavelli, V., Peri, C. and Rizzolo, A. (2000). Antioxidant Activity of Tomato Products As Studied by Model Reactions Using Xanthine Oxidase, Myeloperoxidase, and Copper-Induced Lipid Peroxidation. J. Agric. Food Chem., 48(5), pp.1442-1448. )
  • Xanthine oxidase inhibitor --- (29. Parveen, J. (2012). Bioactivity analysis of lemongrass (Cymbopogan citratus) essential oil.International Food Research Journal, 19(2), pp.569-575 )
  • inhibit the xanthine oxidase enzyme --- ( Ansari, K., Akram, M. and Asif, H. (2011). XANTHINE OXIDASE INHIBITION BY SOME MEDICINAL PLANTS. International Journal of Applied Biology and Pharmaceutical Technology, 2(1), pp.124-131 )

  •   ►  URL -- http://www.ncbi.nlm.nih.gov/pubmed/10820040, http://www.ifrj.upm.edu.my/19%20(02)%202012/(29)IFRJ-2012%20Mirghani.pdf, file:///C:/Users/Administrator/Downloads/5GOUT%20(7).pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- L-CARNITINE with Dietary Substance is Drug Inhibitor,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- KELP with Taking high dose could provide too much iodine and interfere with the action of this medicine., TURMERIC with turmeric reduce drug induce toxicity and may also reduce effectiveness of drug, medicine form salt with polyvalent metal (antacid).,

      ►  Reference :-
  • PDR for herbal medicine. (2016) (4th ed.). Thomson Reuters, 2007.

  •   ►  URL -- ed.). U.S. http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf , ,

    ►   Route of Elimination :   Fecal, Hepatic (Metabolism), Renal, breast milk,
    Ref :-   Book : Martindale    Page : 601   Edition : 37,


    ►    Plasma Half-life :   Min value :-   1 hours,    Max value :-   2 hours,
    Ref :-   Book : Martindale    Page : 600   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,