Alprazolam is a Medicine belongs to BENZODIAZEPINES group whose information about Brand can be referenced from   Book : Martindale    Page : 1062   Edition : 37  

  ►   Brandname : Alprax, Kalma, Niravam, Restyl, Xanax, Tafil
  ►  Strength : Tablet with 0.25 Mg.  Tablet with 0.5 Mg.  Disintegrating tablets with 1.0 mg/ml.  Tablet with 1 mg.  Tablet with 2 mg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 387   Edition : 12      Page :    Edition :   
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 1062   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Anxiety disorders Oral 250 500 Microgram Tablet t.i.d.
2 panic disorder Oral 500 micrograms Tablet t.i.d. Given to patients with or withhout agoraphobia.

Ref :-  Book : Martindale    Page : 1062   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Drowsiness, Sedation, Muscle weakness, Ataxia, Vertigo, Headache, Confusion, Depression, Slurred speech, Changes in libido, Tremor, Visual disturbances, Urinary incontinence, Urinary retention, Amnesia, Jaundice, Hypersenstivity, Pain, Thrombophlebitis
Ref :-   Book : Martindale    Page : 1062   Edition : 37.      Page :    Edition : .  

►  Drug Interaction : Drug interaction of Alprazolam is with Alcohol, antidepressants, sedating antihistamine , Antipsychotics, General anaesthetics , , opioid analgesics,  NA

  ►    Mechanism of Drug Drug Interaction :  Enhanced sedation or respiratory and cardiovascular depression may occur if diazepam or other benzodiazepines are given with other drugs that have CNS depressant properties; these include alcohol, antidepressants antidepressants, sedative antihistamines, antipsychotics, general anaesthetics, other hypnotics or sedatives, and opioid analgesics. Adverse effects may also be produced by use with drugs that interfere with the metabolism of benzodiazepines.
Ref :-   Book : Martindale    Page : 1068   Edition : 38.  


►  Contraindication : Acute pulmonary insufficiency, Myasthenia gravis, Pre-existing CNS depression or coma, Sleep apnea, Respiratory depression
Ref :-   Book : Martindale    Page : 1062   Edition : 37.  
  ►  Mechanism of Action :   Bind to specific GABAA receptor subunits at central nervous system (CNS) neuronal synapses facilitating frequency of GABA-mediated chloride ion channel opening—enhance membrane hyperpolarization.
Ref :-   Book : Basic & Clinical pharmacology    Page : 386   Edition : 12.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication DIETARY Substance


​   ► This Medicine contraindicate with :- EVENING PRIMROSE OIL with Potential risk of seizures..   ALCOHOL with Drinking alcoholic beverage while taking alprazolam may increase side effects such as drowsiness , confusion , and dizziness ..   VALERIAN with Valerian cause sedative effect with alprazolam..  

  ►  Reference :- NA
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL --
    http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf
    https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf

    ►   Route of Elimination :   Renal
    Ref :-   Book : Martindale    Page : 1062   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   11 hours,    Max value :-   15 hours.  
    Ref :-   Book : Martindale    Page : 1062   Edition : 37.  

    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   2 hours.  
    Ref :-   Book : Martindale    Page : 1062   Edition : 37.