Alprostadil is a Medicine belongs to Non Sterodial Anti- Inflammatory Drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 2386   Edition : 37, Martindale    Page : 2386   Edition : 37,

  ►   Brandname : Prostin VR,Caverject,Muse,Edex,Liple

  ►  Strength : Injection with 5  mcg, Injection with 10  mcg, Injection with 20  mcg, Injection with 40  mcg, Injection with 500  mcg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 328   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : intracavernosal injection, intra-urethral,
Reference :-   Book : Martindale    Page : 2352   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Erectile dysfunction intracavernosal injection 5 60 micrograms Injection
2 Erectile dysfunction of neurogenic origin intracavernosal injection 1.25 Microgram Injection For cases of erectile dysfunction of neurogenic origin secondary to spinal cord injury.
3 Erectile dysfunction intra-urethral 250 Microgram b.d.

Ref :-  Book : Martindale    Page : 2352   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Maintain patency of ductus arteriosus in neonates IV infusion 50 100 nanograms/kg per minute Injection

Ref :- Book : Martindale    Page : 2352   Edition : 38,
►  Side Effect : Apnoea, fever, flushing, hypotension, bradycardia, tachycardia, diarrhea, convulsion, oedema, cardiac arrest, cortical proliferation of the long bones, Weakening of the wall of the ductus arteriosus, headache, Pain, inflammation, disseminated intravascular coagulation, Weakening of the wall of pulmonary artery, hypokalaemia, penile fibrosis, Peyronie’s disease, pain during erection,
Ref :-   Book : Martindale    Page : 2385   Edition : 37,    Page :    Edition : ,

►  Drug Interaction : Drug interaction of Alprostadil is with NA

  ►    Mechanism of Drug Drug Interaction :  ,
Ref :-   Book :    Page :    Edition : ,


►  Contraindication : anatomical deformation of the penis, or trait leukemia , myeloma, neonatal respiratory distress syndrome, penile implant, Sickle cell anemia ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 763   Edition : 3,
  ►  Mechanism of Action :   Alprostadil is a prostaglandin that causes vasodilatation and prevents platelet aggregation.,
Ref :-   Book : Martindale    Page : 2607   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Spinach with Another pathway,

  ►  Pathway with its reference as follows :-
  • nitric oxide have vasodilator effect --- (Hord, N., Tang, Y., & Bryan, N. (2009). Food sources of nitrates and nitrites: the physiologic context for potential health benefits. American Journal Of Clinical Nutrition, 90(1), 1-10. )

  •   ►  URL -- http://ajcn.nutrition.org/content/90/1/1.full,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 238   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA