Alteplase is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1331   Edition : 37,

  ►   Brandname : Actilyse,Activase,Activacin

  ►  Strength : Injection with 50  Mg, Injection with 100  Mg, Injection with 2  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 617   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV,
Reference :-   Book : Martindale    Page : 1330   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Acute myocardial infarction IV 100 mg Injection Drug is given as soon as possible after the onset of symptoms; the total dose should not exceed 1.5 mg/kg in patients weighing less than 65 kg.
2 Acute massive pulmonary embolism IV bolus 10 100 mg Injection The first 10 mg is given as an i.v bolus and the remainder by i.v infusion over 2 hours.
3 Acute ischaemic stroke IV 900 microgram/kg Injection Drug is given within 3 hours of the onset of symptoms.
4 To restore function in central venous lines catheter 2 mg Injection

Ref :-  Book : Martindale    Page : 1330   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Arterial or venous thromboembolism in children IV infusion 100 600 micrograms/kg/hour Injection

Ref :- Book : Martindale    Page : 1542   Edition : 37,
►  Side Effect : allergic reactions,
Ref :-   Book : Martindale    Page : 1541   Edition : 37,

►  Drug Interaction : Drug interaction of Alteplase is with Antiplatelet drugs, , ,  Heparin , Aspirin (Acetylsalicylic acid), Dextran, Aspirin,
Ref :-   Book : Martindale    Page : 1541   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Oral anticoagulants, heparin, and antiplatelet drugs such as aspirin are often used with streptokinase, but may increase the risk of haemorrhage. The risk may also be increased with dextrans, and with other drugs that affect coagulation or platelet function.,
Ref :-   Book : Martindale    Page : 1541   Edition : 37,


►  Contraindication : recent history of peptic ulcer disease, Pregnancy, haemorrhage, Recent stroke, severe hypertension, Cerebral neoplasm, increased risk of cerebral bleeding, i.m injections, active internal bleeding, oesophageal varices, other bleeding gastrointestinal lesions, pancreatitis, ulcerative colitis , coagulation defects including those due to liver or kidney disease, subacute bacterial endocarditis, childbirth, trauma,
Ref :-   Book : Martindale    Page : 1541   Edition : 37,
  ►  Mechanism of Action :   Alteplase is a thrombolytic drug. It is a mainly single chain form of the endogenous enzyme tissue plasminogen activator and is produced by recombinant DNA technology. Like endogenous tissue plasminogen activator, alteplase converts fibrin-bound plasminogen to the active form plasmin, resulting in fibrinolysis and dissolution of clots.,
Ref :-   Book : Martindale    Page : 1330   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Garlic with Another pathway,

  ►  Pathway with its reference as follows :-
  • Garlic having active constituent Allicin which act as anticoagulant . --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Hepatic (Metabolism),
    Ref :-   Book : Martindale    Page : 1330   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   40 min,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1330   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA