Amantadine is a Medicine belongs to Antiviral group whose information about Brand can be referenced from   Book : Martindale    Page : 879   Edition : 37, Martindale    Page : 1614   Edition : 37,

  ►   Brandname : Symmetrel,Amantrel,Lysovir,Amixx,Ethibloc

  ►  Strength : Tablet with 100  Mg, Capsule with 100  Mg, Syrup with 50/5  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 888   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 878   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Parkinson’s disease Oral 100 mg Tablet o.d.
2 Herpes zoster Oral 100 mg Tablet b.d. given for 14 days.
3 Influenza A Oral 100 mg Tablet o.d. Given for about 5 days.

Ref :-  Book : Martindale    Page : 878   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Influenza A 1 Year 9 Year Oral 4.4 8.8 mg/kg Syrup
2 Influenza A Above 9 Year Oral 100 mg Syrup b.d.

Ref :- Book : Martindale    Page : 878   Edition : 37,
►  Side Effect : ankle oedema, anorexia, anxiety, ataxia, Blurred Vision, changes in mood, Confusion, congestive heart failure, constipation, convulsion, diaphoresis, difficulties in concentration, Dizziness, dyskinesia, hallucinations, headache, insomnia, lethargy, leucopenia, Livedo reticularis, nausea, neutropenia, nightmares, oculogyric episode, Orthostatic hypotension, palpitation, photosensitisation, psychotic reactions, Skin rashes, slurred speech, urinary retention, vomiting,
Ref :-   Book : Martindale    Page : 877   Edition : 37,

►  Drug Interaction : Drug interaction of Amantadine is with Antimuscarinic, , ,  Levodopa ,
Ref :-   Book : Martindale    Page : 877   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Amantadine may enhance the adverse effects of antimuscarinics and the dose of these drugs should be reduced when used with amantadine; adverse effects of levodopa may also be exacerbated. Licensed product information states that amantadine should be used with caution in patients receiving drugs that affect the CNS. The rate of excretion of amantadine may be reduced by drugs that raise urinary pH.,
Ref :-   Book : Martindale    Page : 877   Edition : 37,


►  Contraindication : other seizure disorders, Untreated angle-closure glaucoma, severe renal disease, Gastric ulceration, history of epilepsy,
Ref :-   Book : Martindale    Page : 877   Edition : 37,
  ►  Mechanism of Action :   Amantadine is a weak dopamine agonist with some antimuscarinic activity; it is also an antagonist at N-methyl- D-aspartate receptors. Amantadine has mild antiparkinsonian activity. Amantadine is also an antiviral that inhibits replication of influenza type A virus; it has very little or no activity against influenza type B virus.,
Ref :-   Book : Martindale    Page : 878   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Ashwagandha with Another pathway, Ashwagandha with Another pathway, Fava beans i.e. bakla with same compound, Bacopa monnieri i. e brahmi with same pathway, Tulsi with Another pathway, Chammomila with Another pathway, Thyme with Another pathway, orange with Another pathway, Rosemary with Another pathway, Parsley with Another pathway, Quercetin with Another pathway,

  ►  Pathway with its reference as follows :-
  • Withanine is Increases Dopamine level --- ( Singh, N., Bhalla, M., De Jager, P., & Gilca, M. (2011). An Overview on Ashwagandha: A Rasayana (Rejuvenator) of Ayurveda. African Journal Of Traditional, Complementary And Alternative Medicines, 8(5S). http://dx.doi.org/10.4314/ajtcam.v8i5s.9 )
  • Terpenoides have Anti-malarial property --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )
  • Fava beans rich in levo-dihydroxyphenylalanine(L-Dopa) the precursor of dopamine. --- (Mehran S.M., Mohseni. "Simultaneous Determination Of Levodopa And Carbidopa From Fava Bean, Green Peas And Green Beans By High Performance Liquid Gas Chromatography". JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH (2013): n. pag. Web. 10 Nov. 2016. )
  • NMDA receptor angagonist . --- (Aguiar, Sebastian. "Neuropharmacological Review Of The Nootropic Herb Bacopa Monnieri". 16 4 (2013): 313-326. Web. 21 Jan. 2017. )
  • Tulsi rich in epigenin enhane the antiviral activity of aciclovir . --- (Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand )
  • Chammomila rich in apigenin enhance the antiviral activity of aciclovir --- (Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand )
  • Thyme rich in apigenin enhance the antiviral activity of aciclovir. --- (Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand )
  • Oregano rich in apigenin enhance the antiviral activity of aciclovir. --- (Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand )
  • Rosemary rich in apigenin enhance the antiviral activity of aciclovir . --- (Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand )
  • Parsley rich in apigenin enhance the antiviral activity of aciclovir. --- (Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand )
  • Quercetin enhance the antiviral activity of aciclovir --- (Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand )

  •   ►  URL -- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252722/, http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708185/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746283/, https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- BELLADONNA with Increasing anticholinergic activity of tricyclic antidepressants .,

      ►  Reference :-
  • Duke, J. (2002). Handbook of Medicinal Herbs (2nd ed.). Boca Raton London New York Washington ,D.C.

  •   ►  URL -- http://www.crcnetbase.com/doi/pdf/10.1201/9781420040463.fmatt,

    ►   Route of Elimination :   Renal, breast milk,
    Ref :-   Book : Martindale    Page : 878   Edition : 37,


    ►    Plasma Half-life :   Min value :-   15 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 878   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   4 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 877   Edition : 37,