Amifostine is a Medicine belongs to Chelators Antidotes and Antagonists group whose information about Brand can be referenced from   Book : Martindale    Page : 1540   Edition : 38,

  ►   Brandname : Amiphos,Ethyol,Amfos,An Fu Ding

  ►  Strength : Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 1539   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV,
Reference :-   Book : Martindale    Page : 1539   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Chemotherapy IV infusion 910 mg/m2 Injection o.d. Given by i.v infusion over 15 minutes starting no more than 30 minutes before the antineoplastic therapy.
2 Prevention of xerostomia IV infusion 200 mg/m2 Injection Dose given daily; as a 3-minute i.v infusion started 15 to 30 minutes before radiotherapy.
3 Reduction of cumulative renal toxicity of Cisplatin therapy 740 mg/m2 Injection only if doses of cisplatin of less than 100 mg/m2 are used.

Ref :-  Book : Martindale    Page : 1539   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Transient reduction in blood pressure, nausea, vomiting, reduces serum-calcium concentrations, flushing, chill, Somnolence, hiccups, sneezing, hypersensitivity reactions, Anaphylactoid reactions, Stevens-Johnson syndrome, toxic epidermal necrolysis, ,
Ref :-   Book : Martindale    Page : 1540   Edition : 38,    Page :    Edition : ,

►  Drug Interaction : Drug interaction of Amifostine is with Antihypertensive Agents ,  NA

  ►    Mechanism of Drug Drug Interaction :  Antihypertensives may potentiate hypotension caused by it.,
Ref :-   Book : Martindale    Page : 1540   Edition : 38,


►  Contraindication : dehydration, hypotension, severe acute allergic reaction,
Ref :-   Book : Martindale    Page : 1540   Edition : 38,
  ►  Mechanism of Action :   Amifostine, an aminothiol compound, is a cytoprotective agent. It is converted in the body to its active metabolite WR-1065, which protects noncancerous cells against the toxic effects of antineoplastics and ionising radiation,
Ref :-   Book : Martindale    Page : 1539   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Vinca with Another pathway,

  ►  Pathway with its reference as follows :-
  • Anticancer . --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 1540   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   less than 10 min,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1540   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA