Amikacin is a Medicine belongs to AMINOGLYCOSIDES group whose information about Brand can be referenced from   Book : Martindale    Page : 215   Edition : 38,

  ►   Brandname : Amicin,Amikin,Acil,Mi Li Xian

  ►  Strength : Injection with 50  Mg, Injection with 250  Mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 828   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IM, IV,
Reference :-   Book : Martindale    Page : 214   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Tuberculosis IM or IV 15 30 mg/kg Injection Given daily.
2 Uncomplicated urinary-tract infections slow i.v 250 mg Injection b.d.
3 Care-Associated Pneumonia IV 20 mg/kg Injection o.d. Given to patients with Risk factors for MDR pathogens, + two more antibiotics.
4 Bacteremia IV 7.5 mg/kg Injection b.d. For nonneutropenic host.

Ref :-  Book : Harrison's principles of internal medicine    Page : 1377   Edition : 18, Martindale    Page : 214   Edition : 38, Harrison's principles of internal medicine    Page : 2139   Edition : 18, Harrison's principles of internal medicine    Page : 1269   Edition : 18,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Infections caused by gram-negative bacilli 0 Day 7 Day 1.2 to 2 kg IM or IV 7.5 mg/kg Injection b.d.
2 Infections caused by gram-negative bacilli 0 Day 7 Day more than 2 kg IM or IV 10 mg/kg Injection b.d.
3 Infections caused by gram-negative bacilli More than 7 days 1.2 to 2 kg IM or IV 7.5 mg/kg Injection t.i.d.
4 Infections caused by gram-negative bacilli More than 7 days more than 2 kg IM or IV 10 mg/kg Injection t.i.d.
5 Infections caused by gram-negative bacilli IM or IV 15 25 mg/kg/day Injection
6 DRUG-RESISTANT TUBERCULOSIS IM or IV 15 30 mg/kg/day Injection
7 CYSTIC FIBROSIS, P. aeruginosa IV 15 30 mg/kg/day Injection
8 BACTERIAL MENINGITIS 8 Day 28 Day 20 30 mg/kg/day
9 BACTERIAL MENINGITIS 0Day 7Day 15 20 mg/kg/day
10 BACTERIAL MENINGITIS 20 30 mg/kg/day

Ref :- Book : Nelson's textbook of Pediatrics    Page : 903, 1008, 1492, 2093   Edition : 19,
Precaution :- If a Patient is using 'Amikacin' drug in  acute kidney injury   disease, then Please be used with caution .

Precaution :- If a Patient is using 'Amikacin' drug in  botulism  disease, then Please aminoglycoside potentiate meuro muscular blockade .

Precaution :- If a Patient is using 'Amikacin' drug in  Acute Renal Failure  disease, then Please amikacin and alike drugs to be avoided .

Precaution :- If a Patient is using 'Amikacin' drug in  Urinary infection   disease, then Please Contraindication: Impaired renal function .

►  Side Effect : ototoxicity, Acute renal failure, neuromuscular blockade, respiratory paralysis, ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 596   Edition : 3, Martindale    Page : 306   Edition : 38,

►  Drug Interaction : Drug interaction of Amikacin is with General anaesthetics , Bisphosphonates, Beta-lactam antibacterial , , ,  Vancomycin , Cyclosporine , Cisplatin , Fludarabine, Etacrynic acid, Dimenhydrinate , Atracurium , Zalcitabine,
Ref :-   Book : Martindale    Page : 214   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Other aminoglycosides, vancomycin, some cephalosporins, ciclosporin, cisplatin, and fludarabine, or of potentially ototoxic drugs such as etacrynic acid and perhaps furosemide, may increase the risk of aminoglycoside toxicity. It has been suggested that use of an antiemetic such as dimenhydrinate may mask the early symptoms of vestibular ototoxicity. Care is also required if other drugs with a neuromuscular-blocking action are used. The neuromuscular-blocking properties of aminoglycosides may be sufficient to provoke severe respiratory depression in patients given general anaesthetics or opioid. Renal excretion of zalcitabine may be reduced by aminoglycosides. Since aminoglycosides have been shown to be incompatible with some beta lactams in vitro, these antibacterials should be given separately if both are required; antagonism in vivo has been reported only in a few patients with severe renal impairment, in whom aminoglycoside activity was diminished. Aminoglycosides exhibit synergistic activity with a number of beta lactams in vivo. Severe hypocalcaemia is reported in a patient treated with aminoglycosides and bisphosphonates. Gentamicin may inhibit α-galactosidase activity and should not be used with agalsidase alfa or beta.,
Ref :-   Book : Martindale    Page : 214,307   Edition : 38,


►  Contraindication : Pregnancy, Hypersensitivity, myasthenia gravis,
Ref :-   Book : Martindale    Page : 214, 306, 307   Edition : 38,
  ►  Mechanism of Action :   Amikacin bind to specific 30S-subunit ribosomal proteins. Protein synthesis is inhibited by the drug in at least three ways : (1) interference with the initiation complex of peptide formation; (2) misreading of mRNA, which causes incorporation of incorrect amino acids into the peptide and results in a nonfunctional or toxic protein; and (3) breakup of polysomes into nonfunctional monosomes. These activities occur more or less simultaneously, and the overall effect is irreversible and lethal for the cell. ,
Ref :-   Book : Basic & Clinical pharmacology    Page : 821,822   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Red algae with Another pathway, Turmeric with Another pathway, Thyme with Another pathway,

  ►  Pathway with its reference as follows :-
  • antibiotics effects --- (Kokate, C. (2013). Pharmacognosy. Pune: Nirali Prakashan. )
  • curcumin have antibacterial effect --- ( Pdr For Herbal Medicine. 4th ed. 2016. Print. )
  • Antibacterial effect --- (. PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html, https://www.amazon.com/PDR-Herbal-Medicines-Thomson-Healthcare/dp/1563636786#reader_1563636786, http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- BANANA with Avoid these food rich in potassium because it increases the side effect of drug.,

      ►  Reference :-

  •   ►  URL -- ,

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 215   Edition : 38,


    ►    Plasma Half-life :   Min value :-   2 hours,    Max value :-   3 hours,
    Ref :-   Book : Martindale    Page : 215   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   1 hour,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 215   Edition : 38,