Amiloride is a Medicine belongs to Diuretic Agents group whose information about Brand can be referenced from   Book : Martindale    Page : 1333   Edition : 37, Martindale    Page : 1299   Edition : 38,

  ►   Brandname : Amilamont,Midamor,Kaluril,Bi Da Shu

  ►  Strength : Tablet with 5  Mg, Oral solution with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 269   Edition : 12, Martindale    Page : 1300   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1332   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Oedema Oral 5 10 mg Tablet o.d.

Ref :-  Book : Martindale    Page : 1332   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Oedema or congestive heart failure Oral 100 200 microgram/kg b.d.

Ref :- Book : Martindale    Page : 1332   Edition : 37,
►  Side Effect : hyperkalaemia, nausea, vomiting, abdominal pain, diarrhea, constipation, paraesthesia, thirst, Dizziness, Skin rashes, pruritus, weakness, muscle cramps, headache, minor psychiatric, visual changes, Orthostatic hypotension, alopecia, Cough, dyspnoea, jaundice, encephalopathy, impotence, angina pectoris, arrhythmia, palpitations, hyponatraemia,
Ref :-   Book : Martindale    Page : 1332   Edition : 37,

►  Drug Interaction : Drug interaction of Amiloride is with , Potassium -Sparing Diuretics , Angiotensin converting enzyme inhibitor, Angiotensin II Receptor Antagonist, NSAIDS, Thiazide Diuretics , Antihypertensive Agents ,  Cyclosporine , Trilostane, Carbenoxolone,
Ref :-   Book : Martindale    Page : 1332   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  There is an increased risk of hyperkalaemia if amiloride is given with potassium supplements or with other potassium-sparing diuretics. Amiloride may reduce the ulcer-healing properties of carbenoxolone. As with other diuretics, amiloride may enhance the effects of other antihypertensive drugs. Hyperkalaemia may also occur in patients given amiloride with ACE inhibitors, angiotensin II receptor antagonists, NSAIDs, ciclosporin, or trilostane. In patients taking amiloride with NSAIDs or ciclosporin the risk of nephrotoxicity may also be increased. Severe hyponatraemia may occur in patients taking a potassium-sparing diuretic with a thiazide,
Ref :-   Book : Martindale    Page : 1332   Edition : 37,


►  Contraindication : hyperkalemia, renal impairment,
Ref :-   Book : Martindale    Page : 1537   Edition : 37,
  ►  Mechanism of Action :   Amiloride is a weak diuretic that appears to act mainly on the distal renal tubules. It is described as potassiums paring since, like spironolactone, it increases the excretion of sodium and reduces the excretion of potassium. Unlike spironolactone, however, it does not act by specifically antagonising aldosterone. Amiloride does not inhibit carbonic anhydrase.,
Ref :-   Book : Martindale    Page : 1299   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- beetroot with Another pathway, Celery with Another pathway, Lemon with Another pathway,

  ►  Pathway with its reference as follows :-
  • Potassium sparing diuetic --- (Coles, L. and Clifton, P. (2012). Effect of beetroot juice on lowering blood pressure in free-living, disease-free adults: a randomized, placebo-controlled trial. Nutrition Journal, 11(1). )
  • High water content having diuretic property --- (: Moghadam, M., Imenshahidi, M., & Mohajeri, S. (2013). Antihypertensive Effect of Celery Seed on Rat Blood Pressure in Chronic Administration. Journal Of Medicinal Food, 16(6), 558-563 )
  • Diuretic properties due to high water content --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3545899/, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684138/, http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- IRON with Decrease in Nutrient Level,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- with Excessive potasium loss if they also regularly us.,

      ►  Reference :-
  • PDR for Herbal medicines. (2000) (4th ed.). U.S.

  •   ►  URL -- ed.). U.S. http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf ,

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 1332   Edition : 37,


    ►    Plasma Half-life :   Min value :-   6 hours,    Max value :-   9 hours,
    Ref :-   Book : Martindale    Page : 1332   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   6 hours,    Max value :-   10 hours,
    Ref :-   Book : Martindale    Page : 1299   Edition : 38,