Aminophylline is a Medicine belongs to bronchodilator group whose information about Brand can be referenced from   Book : Martindale    Page : 1202   Edition : 38,

  ►   Brandname : Phyllocontin,Xing you shan,Neophyllin

  ►  Strength : Tablet with 100  Mg, Tablet with 200  Mg, Injection with 250  mg/10 ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 355   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 1227   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Acute severe bronchospasm Slow IV 250 500 mg Injection Given over 20 to 30 min by slow injection or infusion.
2 Chronic bronchospasm Oral 225 450 mg Tablet b.d.

Ref :-  Book : Martindale    Page : 1227   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Acute severe bronchospasm slow i.v 5 mg/kg Injection
2 Chronic bronchospasm in children more than 40 kg Oral 225 mg Tablet b.d.
3 Neonatal apnoea IV 6 mg/kg Injection

Ref :- Book : Martindale    Page : 1227   Edition : 37,
►  Side Effect : nausea, vomiting, abdominal pain, diarrhea, gastrointestinal disturbance, insomnia, headache, anxiety, irritability, Restlessness, tremor, palpitations, cardiac arrhythmia,
Ref :-   Book : Martindale    Page : 1255   Edition : 37,

►  Drug Interaction : Drug interaction of Aminophylline is with , Interferon Alpha, MACROLIDES , Quinolones, Oral Contraceptive, , Beta 2 Agonist, Corticosteroid , Diuretic Agents , Competitive neuromuscular blockers, Beta Blockers ,  Allopurinol , Cimetidine , Disulfiram, Fluvoxamine, Tiabendazole, Viloxazine, Ritonavir, Rifampicin , Sulfinpyrazone, Phenytoin , Halothane , Ketamine , Adenosine , Lithium carbonate ,
Ref :-   Book : Martindale    Page : 1255   Edition : 37, Harrison's principles of internal medicine    Page : 1255   Edition : 37, Martindale    Page : 1257   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Theophylline clearance may be reduced by interaction with other drugs including allopurinol, some antiarrhythmics, cimetidine, disulfiram, fluvoxamine, interferon alfa, macrolide antibacterials and quinolones, oral contraceptives, tiabendazole, and viloxazine, and the dose of theophylline may need to be reduced. Phenytoin and some other antiepileptics, ritonavir, rifampicin, and sulfinpyrazone may increase theophylline clearance, and require an increase in dose or dosing frequency of theophylline. Xanthines can potentiate hypokalaemia caused by hypoxia or associated with the use of beta2-adrenoceptor stimulants (beta2 agonists), corticosteroids, and diuretics. There is a risk of synergistic toxicity if theophylline is given with halothane or ketamine, and it may antagonise the effects of adenosine and of competitive neuromuscular blockers; lithium elimination may be enhanced with a consequent loss of effect. The interaction between theophylline and beta blockers is complex (see below) but use together tends to be avoided on pharmacological grounds since beta blockers produce bronchospasm.,
Ref :-   Book : Martindale    Page : 1257   Edition : 37,


►  Contraindication : Hypersensitivity,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 835   Edition : 3,
  ►  Mechanism of Action :   Nonselective phosphodiesterase inhibitor that prevent the degradation of cAMP; also act as adenosine receptor antagonist. The combined effect is smooth muscle relaxation and bronchodilation. ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 835   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Indian Hemp with Another pathway, Long peper with Another pathway,

  ►  Pathway with its reference as follows :-
  • Antiasthematic property --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )
  • Antiasthematic property --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf, http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- WILLOW BARK with Excessive potasium loss if they also regularly us.,

      ►  Reference :-

  •   ►  URL -- ,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- with St. John's wort-Decrease the blood levels of drug. , WILLOW BARK with Willow bark Contains salicin, which would increase the likehood of side effects of drug. ,

      ►  Reference :-
  • PDR for Herbal medicines. (2000) (4th ed.). U.S.
  • PDR for Herbal medicines. (2000) (4th ed.). U.S.

  •   ►  URL -- , ed.). U.S. http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf ,

    ►   Route of Elimination :   Hepatic (Metabolism), Renal, breast milk,
    Ref :-   Book : Martindale    Page : 1261   Edition : 37,


    ►    Plasma Half-life :   Min value :-   7 hours,    Max value :-   9 hours,
    Ref :-   Book : Martindale    Page : 1261   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   2 hours,
    Ref :-   Book : Martindale    Page : 1261   Edition : 37,