Amiodarone is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1303   Edition : 38, Martindale    Page : 1300   Edition : 38, Martindale    Page : 1336   Edition : 37,

  ►   Brandname : Amyben,Cordarone X,Cordarone,Pacerone,Aldarone,Amiodar,Aratac,Amiogamma,Ancaron

  ►  Strength : Tablet with 100  Mg, Tablet with 200  mg, Tablet with 400  mg, Injection with 150  mg/3 ml, Oral Suspension with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 249   Edition : 12, Martindale    Page : 1303   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 1335   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Control of ventricular and supraventricular arrhythmias Oral 200 mg Tablet t.i.d.
2 In emergencies slow i.v 150 300 mg Injection Given over a period of not less than 3 minutes; a second injection should not be given until at least 15 minutes after the first.

Ref :-  Book : Martindale    Page : 1335,1336   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Cardiac arrhythmias IV 5 mg/kg Injection
2 Cardiac arrhythmias IV infusion 5 10 mg/kg Injection

Ref :- Book : Martindale    Page : 1336   Edition : 37,
Precaution :- If a Patient is using 'Amiodarone' drug in Ventricular tachycardia disease, then Please Use with caution   if he ever suffered from Acute Kidney Injury disease.
Precaution :- If a Patient is using 'Amiodarone' drug in  Cardiac Disease  disease, then Please contaraindicated in lactation .

Precaution :- If a Patient is using 'Amiodarone' drug in  Congenital Hyperthyroidism  disease, then Please to be avoided .

►  Side Effect : severe bradycardia, sinus arrest, conduction disturbances, Severe hypotension, ventricular tachycardia, ventricular tachyarrhythmia, pulmonary fibrosis, interstitial pneumonitis, hepatitis, benign yellowish-brown corneal microdeposits, haemolytic anaemia, aplastic anaemia, peripheral neuropathy, paraesthesia, myopathy, ataxia, tremor, nausea, vomiting, metallic taste, nightmares, headache, sleeplessness, fatigue, epididymitis, thrombophlebitis, anaphylactic shock, hot flushes, sweating, phospholipidosis, hypothyroidism, photosensitivity, cirrhosis, hyperthyroidism, , increases the formation of reverse-T3, abnormal liver fuction tests, benign intracranial hypertension,
Ref :-   Book : Martindale    Page : 1333   Edition : 37,    Page :    Edition : ,

►  Drug Interaction : Drug interaction of Amiodarone is with Beta Blockers , HIV- protease inhibitors, , , Calcium Channel Blockers , , FLUOROQUINOLONES , Phenothiazine antipsychotics, Tricyclic antidepressants,  Cimetidine , , Rifampicin , Cyclosporine , Clonazepam, Digoxin , Flecainide Acetate , Phenytoin , Procainamide , Quinidine , Simvastatin , Warfarin , Clonazepam, Halofantrine, Terfenadine,
Ref :-   Book : Martindale    Page : 1335   Edition : 37, Martindale    Page : 1355   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Amiodarone should be used with caution with other drugs liable to induce bradycardia, such as beta blockers or calcium-channel blockers, and with other antiarrhythmic drugs. Use with arrhythmogenic drugs, particularly drugs that prolong the QT interval such as phenothiazine antipsychotics, tricyclic antidepressants, halofantrine, and terfenadine, should be avoided. Drugs that cause hypokalaemia or hypomagnesaemia may also increase the risk of arrhythmias with amiodarone. Amiodarone is metabolised by the cytochrome P450 isoenzymes CYP3A4 and CYP2C8 and interactions may occur with inhibitors of these enzymes, particularly with inhibitors of CYP3A4 such as HIV-protease inhibitors, cimetidine, and grapefruit juice. Enzyme inducers such as rifampicin and phenytoin may reduce amiodarone concentrations. Amiodarone is an inhibitor of some cytochrome P450 isoenzymes, including CYP3A4 and CYP2D6, resulting in higher plasma concentrations of other drugs metabolised by these enzymes. Examples of these include ciclosporin, clonazepam, digoxin, flecainide, phenytoin, procainamide, quinidine, simvastatin, and warfarin.,
Ref :-   Book : Martindale    Page : 1335   Edition : 37,


►  Contraindication : patients receiving ritonavir, bradycardia with syncope, second -or- third degree AV block, severe SA-node disease, benzyl alcohol,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 421   Edition : 3, Martindale    Page : 1335   Edition : 37,
  ►  Mechanism of Action :   Block K+ channels, resulting in longer action potential plateau and prolonged repolarization.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 420   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Garlic with Another pathway,

  ►  Pathway with its reference as follows :-
  • Hypotensive Agent --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- PLEURISY ROOT with Pleurisy root & other part in the aesclepicus genus contain glycosides should be avoided with calcium channel blocker drugs.,

      ►  Reference :-

  •   ►  URL -- ,

    ►   Route of Elimination :   Fecal, Renal, Biliary, breast milk,
    Ref :-   Book : Martindale    Page : 1335   Edition : 37,


    ►    Plasma Half-life :   Min value :-   20 days,    Max value :-   100 days,
    Ref :-   Book : Martindale    Page : 1303   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   1 min,    Max value :-   30 min,
    Ref :-   Book : Martindale    Page : 1303   Edition : 38,