Amitriptyline is a Medicine belongs to Tricyclic antidepressant group whose information about Brand can be referenced from   Book : Martindale    Page : 412   Edition : 37,    Page :   Edition : ,

  ►   Brandname : Elavil,sarotena,tryptomer,Endep,Amioxid,Amitone

  ►  Strength : Tablet with 10  Mg, Tablet with 25  Mg, Tablet with 50  Mg, Tablet with 75  Mg, Tablet with 100  Mg, Tablet with 150  Mg, Injection with 10  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 539   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV, IM,
Reference :-   Book : Martindale    Page : 411   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Depression Oral 50 75 mg Tablet Given daily in divided doses.
2 Severely depressed patients Oral 200 mg Tablet Given daily for patients in hospital.

Ref :-  Book : Martindale    Page : 411   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Nocturnal enuresis 6 Year 10 Year Oral 10 20 mg
2 Nocturnal enuresis 11 Year above 11 Year Oral 25 50 mg Tablet

Ref :- Book : Martindale    Page : 411   Edition : 37,
►  Side Effect : dry mouth, constipation, urinary retention, Blurred Vision, increased intraocular pressure, hyperthermia, drowsiness, headache, peripheral neuropathy, tremor, ataxia, tinnitus, extrapyramidal symptoms, Speech Difficulties, sour taste, metallic taste, stomatitis, gastric irritation, nausea, vomiting, Urticaria, angioedema, photosensitisation, testicular enlargement, Gynaecomastia, breast enlargement, galactorrhoea, Confusion, hallucinations, hypomania, behavioural disturbances, Orthostatic hypotension, tachycardia, sexual dysfunction, Changes in blood sugar concentrations, sweating, epileptiform seizures, disturbances in accommodation, delirium mania, ,
Ref :-   Book : Martindale    Page : 406   Edition : 37, Martindale    Page : 406   Edition : 37,    Page :    Edition : ,

►  Drug Interaction : Drug interaction of Amitriptyline is with Alcohol, Barbiturates , Antipsychotics, Calcium Channel Blockers , Monoamine Oxidase Inhibitor, Cyclophosphamide, , , ,  Cimetidine , Methylphenidate , Amiodarone , Cisapride , Sotalol , Adapalene , Quinidine , Astemizole, Terfenadine, Pimozide , Sertindole, Thioridazine , Halofantrine, Epinephrine (adrenaline) , Noradrenaline/Norepinephrine ,
Ref :-   Book : Martindale    Page : 410   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Drugs that inhibit or induce the cytochrome P450 isoenzyme CYP2D6 may affect tricyclic metabolism and produce marked alterations in plasma concentrations. Adverse effects may be enhanced by antimuscarinic drugs or CNS depressants, including alcohol. Barbiturates and other enzyme inducers such as rifampicin and some antiepileptics can increase the metabolism of tricyclic antidepressants and may lower plasma concentrations and reduce antidepressant response. Cimetidine, methylphenidate, antipsychotics, and calciumchannel blockers can reduce the metabolism of the tricyclics, leading to the possibility of increased plasma concentrations and accompanying toxicity. Use of tricyclics with thyroid hormones may precipitate cardiac arrhythmias. The pressor effects of sympathomimetics, especially those of the direct-acting drugs adrenaline and noradrenaline, can be enhanced by tricyclic antidepressants. Drugs that prolong the QT interval, including antiarrhythmics such as amiodarone or quinidine, the antihistamines astemizole and terfenadine, some antipsychotics (notably pimozide, sertindole, and thioridazine), cisapride, halofantrine, and sotalol, may increase the likelihood of ventricular arrhythmias when taken with tricyclic antidepressants. Different antidepressants have been used together under expert supervision in refractory cases of depression, severe adverse reactions including the serotonin syndrome may occur. For this reason an appropriate. Tricyclic antidepressants should not generally be given to patients receiving MAOIs or for at least 2 weeks (3 weeks if starting clomipramine or imipramine) after their withdrawal. ,
Ref :-   Book : Martindale    Page : 410   Edition : 37,


►  Contraindication : urinary retention, prostatic hyperplasia, chronic constipation , phaeochromocytoma, Epilepsy, cardiovascular disease, Cardiac arrhythmias, heart block , hyperthyroidism, Recovery period after myocardial infarction, Untreated angle-closure glaucoma, Blood-sugar concentrations may be altered in diabetic patients, hepatic impairment, Patients should be closely monitored during early antidepressant therapy until significant improvement in depression is observed because suicide is an inherent risk in depressed patients, severe liver disease, regular dental check-ups are recommended for patients on long-term therapy, Drowsiness often occurs, particularly at the start of therapy, and patients, if affected, should not drive or operate machinery, Elderly patients can be particularly sensitive to the adverse effects of tricyclic antidepressants and a reduced dose, especially initially, should be used, Tricyclic antidepressants are not recommended for depression in children,
Ref :-   Book : Martindale    Page : 408   Edition : 37,
  ►  Mechanism of Action :   Inhibit reuptake of 5-HT and NE from the synaptic cleft by respectively blocking 5-HT and NE reuptake transporters, and thereby cause enhancement of postsynaptic responses,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 221   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- with Another pathway,

  ►  Pathway with its reference as follows :-
  • antidepressent effect due to Methylmorphine --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- KAVA with May cause excessive drowsiness when taken with drug. , 5 HTP(5-HYDROXYTRYPTOPHAN) with 5-HTP may cause anxiety confusion and other side effects when taken together with anti-anxiety drug . ,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20, http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,

    ►   Route of Elimination :   Renal, breast milk,
    Ref :-   Book : Martindale    Page : 411   Edition : 37,


    ►    Plasma Half-life :   Min value :-   9 hours,    Max value :-   25 hours,
    Ref :-   Book : Martindale    Page : 411   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   6 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 411   Edition : 37,