Amlodipine is a Medicine belongs to Calcium Channel Blockers group whose information about Brand can be referenced from   Book : Martindale    Page : 1337   Edition : 37,    Page :   Edition : ,

  ►   Brandname : Amlodac,Amlogard,Norvasc,Amlovas,Amlopress,amlostin,Amlo-Q,Amlo,Amlodin,Amlong, Amlong MT,Stamlo,Telma AM,Telma AMH

  ►  Strength : Tablet with 2.5  Mg, Tablet with 5  Mg, Tablet with 10  Mg, Oral Suspension with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 209   Edition : 12, Martindale    Page : 1305   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1337   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 hypertension Oral 5 mg Tablet o.d.

Ref :-  Book : Martindale    Page : 1337   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 hypertension 1 Month 12 Year Oral 100 200 microgram/kg Oral Suspension o.d.

Ref :- Book : Martindale    Page : 1337   Edition : 37,
Precaution :- If a Patient is using 'Amlodipine' drug in  A-V bloock  disease, then Please AS IT INDUCES AV BLOCK .

►  Side Effect : Dizziness, flushing, headache, hypotension, peripheral oedema, tachycardia, palpitations, nausea, gastrointestinal disturbance, increased micturition frequency, lethargy, eye pain, visual disturbances, mental depression, cerebral ischaemia, myocardial ischaemia, transient blindness, Rashes, fever, abnormalities in liver function, cholestasis, gingival hyperplasia, myalgia, tremor, impotence, gastrointestinal obstruction, ischaemic chest pain, vertigo, migraine, Gynaecomastia, ,
Ref :-   Book : Martindale    Page : 1482   Edition : 37,    Page :    Edition : ,

►  Drug Interaction : Drug interaction of Amlodipine is with Beta Blockers , Antipsychotics, , HIV- protease inhibitors,  Quinidine , Cimetidine , Erythromycin , Carbamazapine , Phenytoin , Rifampicin , , Aldesleukin , Insulin ,
Ref :-   Book : Martindale    Page : 1485   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Nifedipine may enhance the antihypertensive effects of other antihypertensive drugs such as beta blockers although the combination is generally well tolerated. Enhanced antihypertensive effects may also be seen if used with drugs such as aldesleukin and antipsychotics that cause hypotension. Nifedipine may modify insulin and glucose responses and therefore diabetic patients may need to adjust their antidiabetic treatment when receiving nifedipine. Extensively metabolised in the liver by the cytochrome P450 isoenzyme CYP3A4, and interactions may occur with other drugs, such as quinidine, sharing the same metabolic pathway, and with enzyme inducers, such as carbamazepine, phenytoin, and rifampicin, and enzyme inhibitors, such as cimetidine, erythromycin, and HIVprotease inhibitors.,
Ref :-   Book : Martindale    Page : 1485   Edition : 37,


►  Contraindication : cardiogenic shock, in patients who have suffered a myocardial infarction in the previous 2 to 4 weeks, acute unstable angina,
Ref :-   Book : Martindale    Page : 1485   Edition : 37,
  ►  Mechanism of Action :   Block voltage –gated L- type calcium channels and prevent the influx of calcium that promotes actin – myosin cross bridge formation. ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 369   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Tomato with same pathway, olive oil with same pathway, Carrot with same pathway, Angeer with Another pathway, Ginger (Zingiber officinale) with same pathway,

  ►  Pathway with its reference as follows :-
  • Act as calcium channel blocker --- ( Tabassum, Nahida. "Role Of Natural Herbs In The Treatment Of Hypertension". Pharmacogn Rev 5.9 (2011): 30–40. Web. 12 Sept. 2016. )
  • Calcium Chanel Blocker --- ( Asif, M. (2013). Biological Significance of Seed Oil and Polyphenolic of Olea europaea. International Journal Of Herbal Medicine, 1(1). )
  • Act as calcium channel blocker --- (Tabassum, Nahida. "Role Of Natural Herbs In The Treatment Of Hypertension". Pharmacogn Rev 5.9 (2011): 30–40. Web. 12 Sept. 2016. )
  • Hypolipidemic effect. --- ( Joseph, Baby. "Pharmacognostic And Phytochemical Properties Of Ficus Carica Linn –An Overview". International Journal of PharmTech Research 3.1 (2017): 08-12,. Print. )
  • Ca2+ channel-blocking activity --- (Ghayur M. Ginger lowers blood pressure through blockade of voltage-dependent calcium channels. Journal of Cardiovascular Pharmacology. 2005;45(1):74-80. )

  •   ►  URL -- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210006/, http://www.florajournal.com/archives/2013/vol1issue1/PartA/5.1.pdf, http://sphinxsai.com/Vol.3No.1/pharm_jan-mar11/pdf/JM11(%20PT=03)%2008-12.pdf, https://insights.ovid.com/pubmed?pmid=15613983,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- CELERY with Dietary Substance is Drug Enhancer,

      ►  Reference :-
  • Williamson, E. (2009). Stockley's Herbal Medicines Interaction .. London: Pharmacutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- PLEURISY ROOT with It contains cardiac glycosides , it is best to avoid use of pleurisy root with heart medications such as calcium ., MULATHI I.E LICORICE with Increase blood pressure & avoided by those taking blood pressure drugs., HOWTHORM with Intensify the blood pressure lowering effect .,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf, https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,

    ►   Route of Elimination :   Renal, Hepatic (Metabolism),
    Ref :-   Book : Martindale    Page : 1337   Edition : 37,


    ►    Plasma Half-life :   Min value :-   35 hours,    Max value :-   50 hours,
    Ref :-   Book : Martindale    Page : 1337   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   6 hours,    Max value :-   12 hours,
    Ref :-   Book : Martindale    Page : 1337   Edition : 37,