Amoxapine is a Medicine belongs to Antidepressant group whose information about Brand can be referenced from   Book : Martindale    Page : 408   Edition : 38,

  ►   Brandname : Demolox,Amolife

  ►  Strength : Tablet with 25  Mg, Tablet with 50  Mg, Tablet with 100  Mg, Tablet with 150  Mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 539   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 413   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Depression Oral 50 mg Tablet b.d/t.i.d

Ref :-  Book : Martindale    Page : 413   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : dry mouth, urinary retention, Blurred Vision, increased intraocular pressure, seizure, Orthostatic hypotension, hyperthermia, drowsiness, insomnia, headache, peripheral neuropathy, tremor, ataxia, epileptiform seizures, tinnitus, extrapyramidal symptoms, Speech Difficulties, Confusion, hallucinations, delirium, sour taste, metallic taste, stomatitis, gastric irritation, nausea, vomiting, breast enlargement, galactorrhoea, Increased appetite, weight gain, hypersenstivity, testicular enlargement, Gynaecomastia, akinesia, akathisia, oculogyric crisis, sexual disturbance, withdrawal dyskinesia, persistent dyskinesia, elevated serum concentration of prolactin, Chorea, , mania or hypomania, tachycardia, Urticaria, angioedema,
Ref :-   Book : Martindale    Page : 412   Edition : 37,    Page :    Edition : ,

►  Drug Interaction : Drug interaction of Amoxapine is with Alcohol, Barbiturates , Antipsychotics, Calcium Channel Blockers , Monoamine Oxidase Inhibitor, , , Thyroid agent , ,  Cimetidine , Methylphenidate , Amiodarone , Cisapride , Sotalol , Cyclophosphamide , Adapalene , Quinidine , Astemizole, Terfenadine, Pimozide , Sertindole, Thioridazine , Halofantrine, Epinephrine (adrenaline) , Noradrenaline/Norepinephrine ,
Ref :-   Book : Martindale    Page : 404,408   Edition : 38, Martindale    Page : 406,408   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Drugs that inhibit or induce the cytochrome P450 isoenzyme CYP2D6 may affect tricyclic metabolism and produce marked alterations in plasma concentrations. Adverse effects may be enhanced by antimuscarinic drugs or CNS depressants, including alcohol. Barbiturates and other enzyme inducers such as rifampicin and some antiepileptics can increase the metabolism of tricyclic antidepressants and may lower plasma concentrations and reduce antidepressant response. Cimetidine, methylphenidate, antipsychotics, and calciumchannel blockers can reduce the metabolism of the tricyclics, leading to the possibility of increased plasma concentrations and accompanying toxicity. Use of tricyclics with thyroid hormones may precipitate cardiac arrhythmias. The pressor effects of sympathomimetics, especially those of the direct-acting drugs adrenaline and noradrenaline, can be enhanced by tricyclic antidepressants. Drugs that prolong the QT interval, including antiarrhythmics such as amiodarone or quinidine, the antihistamines astemizole and terfenadine, some antipsychotics (notably pimozide, sertindole, and thioridazine), cisapride, halofantrine, and sotalol, may increase the likelihood of ventricular arrhythmias when taken with tricyclic antidepressants. Different antidepressants have been used together under expert supervision in refractory cases of depression, severe adverse reactions including the serotonin syndrome may occur. For this reason an appropriate. Tricyclic antidepressants should not generally be given to patients receiving MAOIs or for at least 2 weeks (3 weeks if starting clomipramine or imipramine) after their withdrawal.,
Ref :-   Book : Martindale    Page : 406,408   Edition : 38,


►  Contraindication : not drive or operate machinery, heart block , severe liver disease, Cardiac arrhythmias, in the immediate recovery period after myocardial infarction, for depression in children, elective surgery,
Ref :-   Book : Martindale    Page : 404,408   Edition : 38,
  ►  Mechanism of Action :   The actions of amoxapine resemble those of TCAs such as desipramine. It is potent NET inhibitor and less potent SERT inhibitor. Unlike the TCAs or other antidepressants, amoxapine is a moderate inhibitor of the postsynaptic D 2 receptor. As such, amoxapine possesses some antipsychotic properties.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 531   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Ashwagandha with Another pathway,

  ►  Pathway with its reference as follows :-
  • Act as antidepressant . --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- KAVA KAVA with Kava Kava caue excessive drowsiness when taken together . ,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,

    ►   Route of Elimination :   Renal, breast milk,
    Ref :-   Book : Martindale    Page : 413   Edition : 37,


    ►    Plasma Half-life :   Min value :-   8 hours,    Max value :-   30 hours,
    Ref :-   Book : Martindale    Page : 413   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA