Amoxicillin is a Medicine belongs to PENICILLINS group whose information about Brand can be referenced from   Book : Martindale    Page : 220   Edition : 37,    Page :   Edition : ,

  ►   Brandname : Amoxil,Biomoxil,Amix,Moxatag,Alphamox,Amagesan,Pasetocin,h-p kit

  ►  Strength : Tablet with 125  Mg, Tablet with 200  Mg, Tablet with 250  Mg, Tablet with 400  Mg, Tablet with 500  Mg, Tablet with 875  Mg, Solution with 50  mg/ml, Solution with 125  mg/ml, Solution with 200  mg/ml, Solution with 250  mg/ml, Capsule with 250  mg, Capsule with 500  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 807   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IM, IV,
Reference :-   Book : Martindale    Page : 219   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Severe or recurrent infections of the respiratory tract Oral 3 gm b.d.
2 Uncomplicated gonorrhoea Oral 3 gm Tablet Given as a single dose.
3 Eradication of H. pylori Oral 0.75 1 gm b.d. Given with either metronidazole or clarithromycin and a proton pump inhibitor.
4 Prophylaxis of endocarditis 2 3 gm Given about 1 hour before dental procedures.
5 Severe infections IV 1 gm Injection q.i.d. Given by slow i.v injection over 3 to 4 minutes or by infusion over 30 to 60 minutes.
6 UNCOMPLICATED ACUTE URINARY-TRACT INFECTIONS Oral 3 gm Tablet and repeated once after 10 to 12 hours.

Ref :-  Book : Martindale    Page : 220   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Infections caused by susceptible organisms Oral 125 250 mg Solution
2 Otitis media Oral 90 mg/kg Oral solution
3 Tonsillitis and pharyngitis 12 Year Above 12 Year Oral 775 mg Tablet
4 Infections caused by susceptible organisms IM or IV 50 100 mg/kg Injection

Ref :- Book : Martindale    Page : 220   Edition : 37,
►  Side Effect : diarrhea, nausea, vomiting, allergic reaction, Skin rashes, Pseudomembranous colitis, ,
Ref :-   Book : Harrison's principles of internal medicine    Page : 2450   Edition : 18,    Page :    Edition : ,

►  Drug Interaction : Drug interaction of Amoxicillin is with Anticoagulant ,  Probenecid , Chloramphenicol , Tetracycline ,
Ref :-   Book : Martindale    Page : 219   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Probenecid prolongs the half-life of Amoxicillin by competing with it for renal tubular secretion and may be used therapeutically for this purpose. The possibility of a prolonged bleeding time after oral treatment with a broad-spectrum drug like amoxicillin should be borne in mind in patients receiving anticoagulants. Antagonism has been reported to occur with some bacteriostatic drugs, such as chloramphenicol or tetracyclines, that interfere with active bacterial growth necessary for amoxicillin to achieve its effect. And both enhancement and antagonism of its activity have been demonstrated for beta-lactam combinations. ,
Ref :-   Book : Martindale    Page : 219,232   Edition : 37,


►  Contraindication : hypersensitive to penicillins,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 615   Edition : 3,
  ►  Mechanism of Action :   Amoxicillin inhibits the bacterial growth by interfearing with the transpeptidation reaction of bacterial cell wall synthesis. Amoxicillin like other Beta-lactam antibiotics, a structural analog of the natural D-Ala-D-Ala substrate, covalently bind to the active site of PBPs. This inhibits the transpeptidation reaction, halting peptidoglycan synthesis, and the cell dies,
Ref :-   Book : Basic & Clinical pharmacology    Page : 792   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Garlic with Another pathway,

  ►  Pathway with its reference as follows :-
  • Antibiotic effect --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://www.vitorrentz.in/search/Text+Book+Of+Pharmacognosy, +C.+K.+Kokate, +A.P.+Purohit, +S.B.+Gokhale,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- VITAMIN K with Decrease in Nutrient Level,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- PHYLLIUM with Make antibiotics less effective., BROMELAIN with It improve the action of this drug .,

      ►  Reference :-
  • PDR for Herbal medicines. (2000) (4th ed.). U.S.
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- ed.). U.S. http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf , http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,

    ►   Route of Elimination :   Fecal, Renal, Biliary, breast milk,
    Ref :-   Book : Martindale    Page : 219   Edition : 37,


    ►    Plasma Half-life :   Min value :-   1 hours,    Max value :-   1.5 hours,
    Ref :-   Book : Martindale    Page : 219    Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   2 hours,
    Ref :-   Book : Martindale    Page : 219   Edition : 37,