Amoxicillin and Clavulanic acid is a Medicine belongs to PENICILLINS group whose information about Brand can be referenced from   Book : Martindale    Page : 2766   Edition : 38,    Page :   Edition : ,

  ►   Brandname : Augmentin,Augmexx,Augmentin-Duo,Augmentan,Mega CV,Augmentin Dds

  ►  Strength : Tablet with 250  Mg, Chewable tablets with 200  Mg, Chewable tablets with 125  Mg, Chewable tablets with 400  Mg, Tablet with 500  Mg, Tablet with 875  Mg, Tablet (Extended Release Tablets) with 1000  Mg, Suspension with 125  mg/5mL, Suspension with 200  mg/5mL, Suspension with 250  mg/5mL, Chewable tablets with 250  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 807   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 216   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Infections caused by susceptible organisms Oral / i.v mg Amoxicillin combined with clavulanic acid is given by mouth in a ratio of amoxicillin 2, 4, 7, or 14 parts to 1 part of clavulanic acid, or intravenously in a ratio of 5 parts of amoxicillin to 1 part of clavulanic acid.

Ref :-  Book : Martindale    Page : 216   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Acute Otitis Media 90 mg/kg/day
2 Acute bacterial sinusitis 80 90 mg/kg/day
3 Cystic fibrosis lung infection Oral 25 45 mg/kg/day
4 Vulvovaginal infection caused by S. aureus Oral 20 40 mg/kg/day Suspension

Ref :- Book : Nelson's textbook of Pediatrics    Page : 1437, 1492, 1868, 2207, 2208   Edition : 19,
Precaution :- If a Patient is using 'Amoxicillin and Clavulanic acid' drug in  Infectious Mononucleosis  disease, then Please Not recommended during acute Epstein Barr virus infection as a diffuse rash may develop .

►  Side Effect : diarrhea, nausea, vomiting, hepatitis, cholestatic jaundice, hypersensitivity reactions, Skin rashes, erythematous maculopapular eruptions, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis, haemolytic anaemia, neutropenia, prolongation of bleeding time, defective platelet function, Nephropathy, interstitial nephritis, convulsion, encephalopathy, electrolyte imbalance, Neonatal necrotising enterocolitis, Pseudomembranous colitis, ,
Ref :-   Book : Martindale    Page : 217, 229   Edition : 38,    Page :    Edition : ,

►  Drug Interaction : Drug interaction of Amoxicillin and Clavulanic acid is with Anticoagulant , TETRACYCLINES ,  Probenecid , Chloramphenicol ,
Ref :-   Book : Martindale    Page : 219,232   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Probenecid prolongs the half-life of Amoxicillin by competing with it for renal tubular secretion and may be used therapeutically for this purpose. The possibility of a prolonged bleeding time after oral treatment with a broad-spectrum drug like amoxicillin should be borne in mind in patients receiving anticoagulants. Antagonism has been reported to occur with some bacteriostatic drugs, such as chloramphenicol or tetracyclines, that interfere with active bacterial growth necessary for amoxicillin to achieve its effect. And both enhancement and antagonism of its activity have been demonstrated for beta-lactam combinations.,
Ref :-   Book : Martindale    Page : 219,232   Edition : 37,


►  Contraindication : hypersensitivity to penicillins, use during pregnancy for premature rupture of the fetal membrane,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 615   Edition : 3, Martindale    Page : 217   Edition : 38,
  ►  Mechanism of Action :   Amoxicillin inhibits the bacterial growth by interfearing with the transpeptidation reaction of bacterial cell wall synthesis. Amoxicillin like other Beta-lactam antibiotics, a structural analog of the natural D-Ala-D-Ala substrate, covalently bind to the active site of PBPs. This inhibits the transpeptidation reaction, halting peptidoglycan synthesis, and the cell dies.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 792   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Red algae with Another pathway,

  ►  Pathway with its reference as follows :-
  • Antibiotic effect --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://www.vitorrentz.in/search/Text+Book+Of+Pharmacognosy, +C.+K.+Kokate, +A.P.+Purohit, +S.B.+Gokhale,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- PHYLLIUM with Make antibiotics less effective.,

      ►  Reference :-
  • PDR for Herbal medicines. (2000) (4th ed.). U.S.

  •   ►  URL -- ed.). U.S. http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf ,

    ►   Route of Elimination :   Fecal, Renal,
    Ref :-   Book : Martindale    Page : 219   Edition : 37,


    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA