Amphotericin B is a Medicine belongs to Antifungal group whose information about Brand can be referenced from   Book : Martindale    Page : 573   Edition : 38,

  ►   Brandname : Fungizome,Abelcet,AmBisome,Amfocan,Fungilin,Ampho-Moronal,Amphotec

  ►  Strength : Injection with 50  Mg, Injection with 100  Mg, Cream with 3  %, Lotion with 3  %, Ointment with 3  %, Lozenge with   , Oral Suspension with   , Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 858   Edition : 12, Martindale    Page : 573   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV, intrathecal , intra-articular injection, Intravitreal, inhalation, Topical,
Reference :-   Book : Martindale    Page : 573   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Oral or perioral candidiasis Oral 10 mg Lozenge q.i.d.
2 Intestinal Candidiasis Oral 100 200 mg tablets or suspension q.i.d.
3 Candiduria 50/1000 mg/ml o.d.
4 Cryptococcosis in HIV infected patients 0.7 1.0 mg/kg (with flucytosine); given daily for 2 weeks.
5 Coccidioidomycosis IV 0.7 1 mg/kg Injection Given daily or three times per week.
6 Visceral Leishmaniasis IV infusion 0.75 1.0 mg/kg Injection Dose given on alternate days for a total of 15 infusions.
7 Mucormycosis 1.0 1.5 mg/kg Given daily.
8 Disseminated sporotrichosis 3 5 mg/kg Given daily for 4 to 6 weeks.
9 Candida Esophagitis IV infusion 10 15 mg Injection q.i.d.

Ref :-  Book : Martindale    Page : 570   Edition : 38, Harrison's principles of internal medicine    Page : 1060, 1559, 1645, 1650, 1654, 1663, 1666, 1712, 2436.   Edition : 18, Harrison's principles of internal medicine    Page : 1060, 1559, 1645, 1650, 1654, 1663, 1666, 1712, 2436, 3426.   Edition : 18,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Amebic meningoencephalitis 1.5 mg/kg/day
2 Leishmania infection IV 0.5 1 mg/kg Injection o.d.
3 Fungal infections 1 mg/kg/day Injection
4 Zygomycosis 1-1.5 mg/kg/day

Ref :- Book : Nelson's textbook of Pediatrics    Page : 1056, 1062, 1177, 1190.   Edition : 19,
Precaution :- If a Patient is using 'Amphotericin B' drug in  acute kidney injury   disease, then Please be used with caution .

Precaution :- If a Patient is using 'Amphotericin B' drug in  Leishmaniasis  disease, then Please Contraindications- Renal impairment and Hypokalemia. .

Precaution :- If a Patient is using 'Amphotericin B' drug in  Histoplasmosis  disease, then Please Contraindications- Renal impairment and Hypokalemia. .

►  Side Effect : fever, chill, hypokalaemia, hypomagnesaemia, vomiting, dyspnoea, hypotension, tachypnoea, respiratory stridor, headache, nausea, malaise, weight loss, phlebitis, arachnoiditis, ,
Ref :-   Book : Goodman    Page : 1574   Edition : 12,    Page :    Edition : ,

►  Drug Interaction : Drug interaction of Amphotericin B is with , Glucocorticoids , ,  digitalis, Zidovudine,
Ref :-   Book : Harrison's principles of internal medicine    Page : 1676   Edition : 18,


  ►    Mechanism of Drug Drug Interaction :  Interaction with Antineoplastic agents causes: renal toxicity, bronchospasm, hypotension. Interaction with Glucocorticoids, ACTH, digitalis causes: hypokalemia. Interaction with Zidovudine causes: increased myelo- and nephrotoxicity.,
Ref :-   Book : Harrison's principles of internal medicine    Page : 1676   Edition : 18,


►  Contraindication : Hypersensitivity,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 628   Edition : 3,
  ►  Mechanism of Action :   The antifungal activity of amphotericin B depends principally on its binding to a sterol moiety, primarily ergosterol in the membrane of sensitive fungi. By virtue of their interaction with these sterols, polyenes appear to form pores or channels that increase the permeability of the membrane, allowing leakage of a variety of small molecules.,
Ref :-   Book : Goodman    Page : 1572   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Oregano with Another pathway, Garlic with Another pathway,

  ►  Pathway with its reference as follows :-
  • Terpenoid phenols have Antifungal --- (Soylu, S., Yigitbas, H., Soylu, E., & Kurt, Ş. (2007). Antifungal effects of essential oils from oregano and fennel on Sclerotinia sclerotiorum. Journal Of Applied Microbiology, 103(4), 1021-1030. )
  • Garlic having active constituent Allicin which act as antifungal effect . --- (Kokate, C.K. and A.p. Purohit. Pharmacognosy. Nirali prakashan: Chennai, 2013. Print. )

  •   ►  URL -- http://www.ncbi.nlm.nih.gov/pubmed/17897206, http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- with It reduces bioavailability of drug.,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand.

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 571   Edition : 38,


    ►    Plasma Half-life :   Min value :-   24 hours,    Max value :-   15 days,
    Ref :-   Book : Martindale    Page : 572   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA