Ampicillin is a Medicine belongs to PENICILLINS group whose information about Brand can be referenced from   Book : Martindale    Page : 220   Edition : 38,

  ►   Brandname : Ampilin,Ampipen,Magnapen,Principen,Ampicyn,Ai Luo Di

  ►  Strength : Capsule with 250  Mg, Suspension with 125  Mg, Suspension with 250  Mg, Injection with 125  Mg, Injection with 250  Mg, Injection with 500  Mg, Capsule with 500  mg, Injection with 1  gm, Injection with 2  gm, Tablet with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 807   Edition : 12, Martindale    Page : 220   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IM, IV, Intraperitoneal, Intrapleural injection,
Reference :-   Book : Martindale    Page : 218   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Urinary-tract infections Oral 500 mg Capsule t.i.d.
2 Listerial meningitis IV 12 gm Injection given daily in divided doses every 4 or 6 hours.
3 Typhoid and paratyphoid fever Oral 1 2 gm Capsule q.i.d. given for 2 weeks for acute infections.
4 Uncomplicated gonorrhoea Oral 2 gm Capsule Given as a single oral dose with probenecid 1 gm.
5 Intrapartum prophylaxis against group B streptococcal infection in neonates IV 2 gm Injection It is a maternal dose.

Ref :-  Book : Martindale    Page : 218   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Treatment of susceptible infections 7 Day 21 Day Oral 30 mg/kg Suspension t.i.d.
2 Treatment of susceptible infections 21 Day 28 Day Oral 30 mg/kg Suspension q.i.d.
3 Treatment of susceptible infections 1 Month 1 Year Oral 62.5 mg Suspension q.i.d.
4 Treatment of susceptible infections 1 Year 5 Year Oral 125 mg Suspension q.i.d.
5 Treatment of susceptible infections 5 Year 12 Year Oral 250 mg Suspension q.i.d.
6 Treatment of susceptible infections slow i.v 30 mg/kg Injection b.d.
7 Treatment of susceptible infections 7 Day 21 Day slow i.v 30 mg/kg Injection t.i.d.
8 Treatment of susceptible infections 21 Day 28 Day slow i.v 30 mg/kg Injection q.i.d.
9 Treatment of susceptible infections slow i.v 25 mg/kg Injection q.i.d.
10 Enterococcal endocarditis slow i.v 50 mg/kg Injection b.d.
11 Enterococcal endocarditis 7 Day 21 Day slow i.v 50 mg/kg Injection t.i.d.
12 Enterococcal endocarditis 21 Day 28 Day slow i.v 50 mg/kg Injection q.i.d.
13 Group B streptococcal infections slow i.v 50 mg/kg Injection b.d.
14 Group B streptococcal infections 7 Day 21 Day slow i.v 50 mg/kg Injection t.i.d.
15 Group B streptococcal infections 21 Day 28 Day slow i.v 50 mg/kg Injection q.i.d.
16 Listerial meningitis IV 50 mg/kg Injection b.d.
17 Listerial meningitis 7 Day 21 Day IV 50 mg/kg Injection t.i.d.
18 Listerial meningitis 21 Day 28 Day IV 50 mg/kg Injection q.i.d.
19 Listerial meningitis IV 50 mg/kg Injection
20 Enterococcal endocarditis slow i.v 50 mg/kg Injection
21 Group B streptococcal infections slow i.v 50 mg/kg Injection q.i.d.
22 Treatment of susceptible infections From 12 Year Oral 250 500 mg Capsule q.i.d.

Ref :- Book : Martindale    Page : 219   Edition : 38,
Precaution :- If a Patient is using 'Ampicillin' drug in  Infectious Mononucleosis  disease, then Please Not recommended during acute Epstein Barr virus infection as a diffuse rash may develop. .

►  Side Effect : hypersensitivity reactions, angioedema, erythema multiforme, diarrhea, nausea, vomiting, Pseudomembranous colitis, Hemolytic anemia, neutropenia, prolongation of bleeding time, defective platelet function, neuropathy, interstitial nephritis, convulsion, encephalopathy, electrolyte disturbances, erythematous maculopapular eruptions, ,
Ref :-   Book : Martindale    Page : 219, 229   Edition : 38, Martindale    Page : 219, 229   Edition : 38,    Page :    Edition : ,

►  Drug Interaction : Drug interaction of Ampicillin is with TETRACYCLINES , ,  Probenecid , Chloramphenicol ,
Ref :-   Book : Martindale    Page : 230   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Probenecid prolongs the half-life of Ampicillin by competing with it for renal tubular secretion and may be used therapeutically for this purpose. Antagonism has been reported to occur with some bacteriostatic drugs, such as chloramphenicol or tetracyclines, that interfere with active bacterial growth necessary for amoxicillin to achieve its effect. And both enhancement and antagonism of its activity have been demonstrated for beta-lactam combinations. The possibility of a prolonged bleeding time after oral treatment with a broad-spectrum drug like ampicillin should be borne in mind in patients receiving anticoagulants. ,
Ref :-   Book : Martindale    Page : 221,232   Edition : 37,


►  Contraindication : stopped if skin rash occurs, infectious mononucleosis,
Ref :-   Book : Martindale    Page : 219   Edition : 38,
  ►  Mechanism of Action :   Ampicillin inhibits the bacterial growth by interfearing with the transpeptidation reaction of bacterial cell wall synthesis. Ampicillin is a structural analog of the natural D-Ala-D-Ala substrate, covalently bind to the active site of PBPs. This inhibits the transpeptidation reaction, halting peptidoglycan synthesis, and the cell dies.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 792   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Red algae with Another pathway, Eucalyptus oil with Another pathway,

  ►  Pathway with its reference as follows :-
  • Antibiotic effect --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • Antibiotic effect --- (Duke, J. (2002). Handbook of Medicinal Herbs (2nd ed.). CRC press: Boca Raton Road New York Washington ,D.C . )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html, https://books.google.co.in/books?id=UcLYLpwdcm8C&pg=PA515&lpg=PA515&dq=Duke, +J.+(2002).+Handbook+of+Medicinal+Herbs+(2nd+ed.).+CRC+press:+Boca+Raton+Road+New+York+W,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- VITAMIN K with Decrease in Nutrient Level, VITAMIN C with Decrease in Nutrient Level, DIETARY FIBER with Dietary Substance is Drug Inhibitor,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- PHYLLIUM with Make antibiotics less effective., ALCOHOL with It blocks the action of ampicillin , KHAT (CATHA EDULIS) with It reduces the absorption of ampicillin , BROMELAIN with It improve the action of this drug .,

      ►  Reference :-
  • PDR for Herbal medicines. (2000) (4th ed.). U.S.
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • 7. Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- ed.). U.S. http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf , http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf, http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,

    ►   Route of Elimination :   Fecal, Renal, Biliary, breast milk,
    Ref :-   Book : Martindale    Page : 222   Edition : 37,


    ►    Plasma Half-life :   Min value :-   1 hours,    Max value :-   1.5 hours,
    Ref :-   Book : Martindale    Page : 222    Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   2 hours,
    Ref :-   Book : Martindale    Page : 222   Edition : 37,