Amyl Nitrite is a Medicine belongs to Chelators Antidotes and Antagonists group whose information about Brand can be referenced from   Book : Martindale    Page : 1541   Edition : 38,

  ►   Brandname : Cyanide Antidote Package,Emergent-Ez

  ►  Strength : inhalant capsule with 0.3  ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 209   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : inhalation,
Reference :-   Book : Martindale    Page : 1540   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Cyanide poisoning inhalation Inhalation Given by inhalation for up to 30 seconds every minute,

Ref :-  Book : Martindale    Page : 1540   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : flushing, headache, Dizziness, nausea, vomiting, hypotension, Restlessness, pallor, sweating, urinary incontinence, tachycardia, fecal incontinence, increase intra-ocular pressure, increases intracranial pressure,
Ref :-   Book : Martindale    Page : 1540   Edition : 38, Martindale    Page : 1540   Edition : 38,

►  Drug Interaction : Drug interaction of Amyl Nitrite is with NA

  ►    Mechanism of Drug Drug Interaction :  Like organic nitrates, amyl nitrite and other inhaled volatile nitrites may potentiate the hypotensive effects phosphodiesterase type5 inhibitors,
Ref :-   Book : Martindale    Page : 1541   Edition : 38,


►  Contraindication : NA
  ►  Mechanism of Action :   It has been used in the immediate treatment of patients with definite cyanide poisoning to induce the formation of methaemoglobin, which combines with the cyanide to form non-toxic cyanmethaemoglobin,
Ref :-   Book : Martindale    Page : 1540   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- beetroot with same pathway,

  ►  Pathway with its reference as follows :-
  • Beetroot is rich in nitrate which act as vasodilator . --- ( Clifford, T., Howatson, G., West, D., & Stevenson, E. (2015). The Potential Benefits of Red Beetroot Supplementation in Health and Disease. Nutrients, 7(4), 2801-2822. doi:10.3390/nu7042801 )

  •   ►  URL -- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425174/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- HAWTHORN FRUIT with Increased risk of bleeding .,

      ►  Reference :-
  • Posadzki, P., Watson, L., & Ernst, E. (2012). Herb-drug interactions: an overview of systematic reviews. British Journal Of Clinical Pharmacology, no-no. http://dx.doi.org/10.1111/j.1365-2125.2012.04350.x

  •   ►  URL -- http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.2012.04350.x/full,

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 1541   Edition : 38,


    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA