Anakinra is a Medicine belongs to Disease modifying antirheumatic drug group whose information about Brand can be referenced from   Book : Martindale    Page : 21   Edition : 37,

  ►   Brandname : Kineret

  ►  Strength : Injection with 100  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 999   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : SC,
Reference :-   Book : Basic & Clinical pharmacology    Page : 999   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Rheumatoid arthritis SC 100 mg Injection o.d. Given for moderate to severe active disease. The dose should be given at about the same time each day.
2 Cryopyrin-associated periodic syndromes SC 1 2 mg/kg Injection Given daily.

Ref :-  Book : Martindale    Page : 21   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Cryopyrin-associated periodic syndromes mg/kg

Ref :- Book : Martindale    Page : 21   Edition : 38,
►  Side Effect : erythema, Bruising, swelling, Pain, headache, nausea, diarrhea, abdominal pain, ,
Ref :-   Book : Martindale    Page : 21   Edition : 37,    Page :    Edition : ,

►  Drug Interaction : Drug interaction of Anakinra is with Live Vaccines, ,  Etanercept ,
Ref :-   Book : Martindale    Page : 22   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Live vaccines should not be given with anakinra as its effect on vaccine efficacy or the risk of infection transmission is unknown. The risk of serious infection and neutropenia is increased when anakinra and etanercept are used together; a similar effect may occur with other TNF antagonists. The use of anakinra with etanercept or other TNF inhibitors is not recommended.,
Ref :-   Book : Martindale    Page : 22   Edition : 38,


►  Contraindication : if a severe allergic reaction occurs, it should be stopped, patients with active infections including chronic or localised infections, neutropenia,
Ref :-   Book : Martindale    Page : 22   Edition : 38,
  ►  Mechanism of Action :   Recombinant form of the naturally occurring IL-1 receptor antagonist that prevents IL-1 from binding to its receptor, stemming the cascade of cytokines that would otherwise be released.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 996   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Anantmul with Another pathway,

  ►  Pathway with its reference as follows :-
  • Iso-vanillin have Anti inflammatroy property --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- WILLOW BARK with when Willow bark is taken with this drug it increases the like hood of developing sotmach and intestinal ulcers., NONI with Decreased gastric transit time‡, increased risk of hyperkalemia,,

      ►  Reference :-
  • Posadzki, P., Watson, L., & Ernst, E. (2012). Herb-drug interactions: an overview of systematic reviews. British Journal Of Clinical Pharmacology, no-no. http://dx.doi.org/10.1111/j.1365-2125.2012.04350.x

  •   ►  URL -- , http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.2012.04350.x/full,

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 20   Edition : 37,


    ►    Plasma Half-life :   Min value :-   4 hours,    Max value :-   6 hours,
    Ref :-   Book : Martindale    Page : 20    Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   3 hours,    Max value :-   7 hours,
    Ref :-   Book : Martindale    Page : 21   Edition : 37,