Apomorphine is a Medicine belongs to Antiparkinsonian Drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 894   Edition : 38, Martindale    Page : 2004   Edition : 38,

  ►   Brandname : Apokyn,APO-go,Apomine,Li Ke Ji,Chen Ze

  ►  Strength : Injection with 10  mg/ml, Tablet with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 498   Edition : 12, Martindale    Page : 894   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, SC,
Reference :-   Book : Martindale    Page : 880   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Parkinsonism SC 1 mg Injection The optimal dose of apomorphine in the management of ‘off’ periods in parkinsonism should be established individually under specialist care.

Ref :-  Book : Martindale    Page : 893   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : fatigue, Somnolence, highly emetogenic, Other potentially serious side effects include injection-site reactions, QT prolongation, and the development of a pattern of abuse characterized by increasingly frequent dosing leading to hallucinations, dyskinesia, and abnormal behavior,
Ref :-   Book : Goodman    Page : 617   Edition : 12,

►  Drug Interaction : Drug interaction of Apomorphine is with Antihypertensive Agents , , Alcohol, Antipsychotics, ,  Entacapone , Memantine hydrochloride ,
Ref :-   Book : Martindale    Page : 894   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Apomorphine should be used with caution in patients receiving antihypertensives or organic nitrates as it may potentiate their hypotensive effects. Enhanced hypotensive effects may also occur when alcohol is given with apomorphine. The therapeutic effects of apomorphine may be antagonised by antipsychotics and other drugs that act as CNS dopamine inhibitors. The effect of apomorphine is possibly enhanced by entacapone and memantine,
Ref :-   Book : Martindale    Page : 879   Edition : 37,


►  Contraindication : dementia, hypersensitivity to opioids, neuropsychiatric problems, Respiratory or CNS depression, hepatic impairment, patients who have an ‘on’ response to levodopa marred by severe dyskinesia, hypotonia, or psychiatric effects, patients who suffer dizziness, lightheadedness or syncope should not drive or operate machinery,
Ref :-   Book : Martindale    Page : 879   Edition : 37,
  ►  Mechanism of Action :   Apomorphine is a morphine derivative with structural similarities to dopamine. It is a potent dopamine D1- and D2-receptor agonist used in the management of parkinsonism, especially in the control of the ‘on-off’ effect,
Ref :-   Book : Martindale    Page : 880   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Fava beans i.e. bakla with same compound,

  ►  Pathway with its reference as follows :-
  • Fava beans rich in levo-dihydroxyphenylalanine(L-Dopa) the precursor of dopamine. --- (Mehran S.M., Mohseni. "Simultaneous Determination Of Levodopa And Carbidopa From Fava Bean, Green Peas And Green Beans By High Performance Liquid Gas Chromatography". JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH (2013): n. pag. Web. 10 Nov. 2016. )

  •   ►  URL -- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708185/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- GINSENG I.E ASHWAGANDHA with Mania, headache, tremor, and insomnia, reduced blood glucose, HbA1c, plasma cholesterol, triglyceride, LDL, and NEFA; elevated HDL, LH, FSH; altered BP,

      ►  Reference :-
  • Posadzki, P., Watson, L., & Ernst, E. (2012). Herb-drug interactions: an overview of systematic reviews. British Journal Of Clinical Pharmacology, no-no. http://dx.doi.org/10.1111/j.1365-2125.2012.04350.x

  •   ►  URL -- http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.2012.04350.x/full,

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 880   Edition : 37,


    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   40 min,    Max value :-   60 min,
    Ref :-   Book : Martindale    Page : 894   Edition : 38,