Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No	Ailment	Route	Dose Min	Dose Max	Unit	Dosage Form	Frequency	Additional Info
1	Control or prevent a postoperative increase in intraocular pressure	Topical	1		%	Ophthalmic Solution		For patients undergoing anterior segment laser surgery; it is instilled into the eye one hour before surgery and again immediately upon completion of surgery.
2	Raised intra-ocular pressure	Topical	0.5		%	Ophthalmic Solution	t.i.d.	Given for short-term adjunctive therapy when not controlled by conventional therapy.

Adult Dose

S.No	Ailment	Route	Dose Min	Dose Max	Unit	Dosage Form	Frequency	Additional Info
1	Control or prevent a postoperative increase in intraocular pressure	Topical	1		%	Ophthalmic Solution		For patients undergoing anterior segment laser surgery; it is instilled into the eye one hour before surgery and again immediately upon completion of surgery.
2	Raised intra-ocular pressure	Topical	0.5		%	Ophthalmic Solution	t.i.d.	Given for short-term adjunctive therapy when not controlled by conventional therapy.

Ref :-  Book : Martindale    Page : 2004   Edition : 38  

Pediatric Dose

Ref :- Book :

►  Side Effect : Hyperaemia, Lid retraction, Mydriasis, Ocular intolerance reaction, Ocular pruritus, Increased lachrymation, Ocular discomfort, Oedema of the lids, Conjunctival blanching, Blurred Vision, Asthenia, Headache, taste disturbances, Exaggerated reduction in intra-ocular pressure, Oedema of conjunctiva, Conjunctivitis
Ref :-   Book : Martindale    Page : 2004   Edition : 38.  
►  Drug Interaction : Drug interaction of Apraclonidine is with Monoamine Oxidase Inhibitor, Tricyclic antidepressants, ,  NA

  ►    Mechanism of Drug Drug Interaction :  Systemic absorption may occur after topical application of apraclonidine to the eye and there is a theoretical possibility of interactions similar to those reported with clonidine. Since the effects of apraclonidine on circulating catecholamines are unknown, licensed product information recommends that MAOIs should not be given with apraclonidine; tricyclic and related antidepressants and systemic sympathomimetics should also be avoided or used with caution.
Ref :-   Book : Martindale    Page : 2004   Edition : 38.  

►  Contraindication : In case of drowsiness patients should not drive or operate machinery, Treatment should be stopped if these symptoms occur; hyperaemia, ocular pruritus, increased lachrymation, ocular discomfort, and oedema of the lids and conjunctiva.
Ref :-   Book : Martindale    Page : 2004   Edition : 38.  

  ►  Mechanism of Action :   Apraclonidine is α 2 -selective agonist. The mechanism of action of this drug in treating glaucoma is still uncertain; direct neuroprotective effects may be involved in addition to the benefits of lowering intraocular pressure.
Ref :-   Book : Basic & Clinical pharmacology    Page : 145   Edition : 12.  

►   Route of Elimination :   NA

►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA