Aprepitant is a Medicine belongs to Gastrointestinal drug group whose information about Brand can be referenced from   Book : Martindale    Page : 1820   Edition : 38,

  ►   Brandname : Emend,Aprecap

  ►  Strength : Capsule with 40  Mg, Capsule with 80  Mg, Capsule with 125  Mg,

Reference of this Medicine for its Strength can be taken from   Book : Goodman    Page : 1344   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1857   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Prevention of acute and delayed nausea and vomiting associated with highly emetogenic or moderately emetogenic cancer chemotherapy Oral 125 mg Capsule Given with a corticosteroid and a 5-HT3 antagonist.
2 Postoperative nausea and vomiting Oral 40 mg Capsule given as a single dose within the 3 hours before induction of anaesthesia.

Ref :-  Book : Martindale    Page : 1819   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : diarrhea, fatigue, Dizziness,
Ref :-   Book : Basic & Clinical pharmacology    Page : 1099   Edition : 12,

►  Drug Interaction : Drug interaction of Aprepitant is with , , , Oral Contraceptive,  Astemizole, Cisapride , Pimozide , Terfenadine, Warfarin , Phenytoin , Tolbutamide , Corticosteroids, Tolvaptan ,
Ref :-   Book : Martindale    Page : 1857   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  During its use for 3 or 4 days in the prevention of nausea and vomiting associated with cancer chemotherapy, aprepitant produces moderate inhibition of the cytochrome P450 isoenzyme CYP3A4. Exposure to oral CYP3A4 substrates may increase substantially; the effect of aprepitant on intravenous CYP3A4 substrates is expected to be less. However, on cessation of aprepitant a transient mild induction of CYP3A4 may become apparent with a maximum effect reached 3 to 5 days later; this effect is maintained for a few days then slowly declines and is clinically insignificant about 2 weeks after stopping aprepitant. Caution is therefore required when using it with drugs that are primarily metabolised by this isoenzyme. Aprepitant should not be given with astemizole, cisapride, pimozide, terfenadine or tolvaptan as increased plasma concentrations of these drugs could cause serious life-threatening reactions. As aprepitant is also a substrate for CYP3A4, other drugs that inhibit or induce this isoenzyme may in turn increase or decrease plasma concentrations of aprepitant. Aprepitant also causes a delayed induction of CYP2C9 and may lower plasma concentrations of drugs metabolised by this isoenzyme, such as warfarin, phenytoin, or tolbutamide. The efficacy of oral contraceptives might be reduced by aprepitant. Aprepitant may increase systemic exposure to corticosteroids.,
Ref :-   Book : Martindale    Page : 1857   Edition : 37,


►  Contraindication : contraindicated in patients on cisapride or pimozide, in whom life-threatening QT prolongation has been reported,
Ref :-   Book : Goodman    Page : 1344   Edition : 12,
  ►  Mechanism of Action :   Aprepitant is a neurokinin-1 (NK1) receptor antagonist used in the management of nausea and vomiting.,
Ref :-   Book : Martindale    Page : 1819   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Ginger (Zingiber officinale) with Another pathway,

  ►  Pathway with its reference as follows :-
  • Ginger having active constituent gingerol which act as antiemetic . --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Fecal, Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 1858   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   9 hours,    Max value :-   13 hours,
    Ref :-   Book : Martindale    Page : 1857   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   4 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1857   Edition : 37,