Aripiprazole is a Medicine belongs to Antipsychotics group whose information about Brand can be referenced from   Book : Martindale    Page : 1040   Edition : 38,

  ►   Brandname : Abilify,Arena,Aria,An Lv Fan

  ►  Strength : Tablet with 2  Mg, Tablet with 5  Mg, Tablet with 10  Mg, Tablet with 15  Mg, Tablet with 20  Mg, Tablet with 30  Mg, Oral solution with 1  mg/ml, Injection with 7.5  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 519   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IM,
Reference :-   Book : Martindale    Page : 1066   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Schizophrenia Oral 10 30 mg Tablet o.d. The usual maintenance dose is 15 mg once daily although the dose may be adjusted at intervals of not less than 2 weeks up to a maximum of 30 mg daily.
2 Acute manic or mixed episodes in bipolar disorder Oral 15 mg Tablet o.d. this may subsequently be increased to 30 mg once daily according to response.
3 Acute agitation in patients with schizophrenia or bipolar mania IM 9.75 15 mg Injection Given as deep i.m injection. Some patients may only need 5.25 mg.
4 Depression Oral 2 5 mg Tablet o.d. Given as an adjunctive therapy.

Ref :-  Book : Martindale    Page : 1065, 1066   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Schizophrenia 13Year 17Year Oral 2 30 mg Tablet
2 Acute manic or mixed episodes in bipolar disorder 10Year 17Year Oral 2 30 mg Tablet
3 Irritability associated with autistic disorder 6Year 17Year Oral 2 5 mg Oral solution o.d.

Ref :- Book : Martindale    Page : 1039   Edition : 38,
►  Side Effect : constipation, dyspepsia, nausea, vomiting, headache, anxiety, insomnia, lightheadedness, drowsiness, weight gain, akathisia, tardive dyskinesia, agranulocytosis, leucopenia, neutropenia, thrombocytopenia, Neuroleptic malignant syndrome, tachycardia, Orthostatic hypotension, ,
Ref :-   Book : Martindale    Page : 1065   Edition : 37,    Page :    Edition : ,

►  Drug Interaction : Drug interaction of Aripiprazole is with , , Alcohol, Antihypertensive Agents , , ,  Ketoconazole , Carbamazapine , Quinidine ,
Ref :-   Book : Martindale    Page : 1065   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  The central effects of other CNS depressants including alcohol may be enhanced by aripiprazole. Aripiprazole may also enhance the effects of antihypertensive drugs. It should be used with caution in patients also receiving drugs that prolong the QT interval or cause electrolyte imbalance. Aripiprazole is metabolised by the cytochrome P450 isoenzymes CYP3A4 and CYP2D6. Ketoconazole, a potent CYP3A4 inhibitor, can increase aripiprazole plasma concentrations by about 60%; licensed product information states that the dose of aripiprazole should be reduced by half when given with ketoconazole. Similarly, the dose of aripiprazole should be halved when given with quinidine, a potent inhibitor of CYP2D6. Conversely, plasma oncentrations of aripiprazole may decrease by about 70% when given with carbamazepine, a potent CYP3A4 inducer; the dose of aripiprazole should be doubled if carbamazepine is added to aripiprazole treatment. Similar effects may occur with other potent inhibitors or inducers of these isoenzymes and a reduced or increased dose of aripiprazole, respectively, in such combinations is recommended.,
Ref :-   Book : Martindale    Page : 1065   Edition : 37,


►  Contraindication : Hypersensitivity,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 205   Edition : 3,
  ►  Mechanism of Action :   While emerging data indicate that stimulation of glutamate or muscarinic receptors may confer antipsychotic properties, no clinically available effective antipsychotic is devoid of D2 antagonistic activity. This reduction in dopaminergic neurotransmission is presently achieved through one of two mechanisms: D2 antagonism or partial D2 agonism, of which aripiprazole is the only current example.,
Ref :-   Book : Goodman    Page : 429   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Poppy seed with Another pathway,

  ►  Pathway with its reference as follows :-
  • Poppy Seed act as antipsychotic effect . --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- 5 HTP(5-HYDROXYTRYPTOPHAN) with Cause anxiety,confusion & other side effect . , EVENING PRIMROSE OIL with Evening Having potent risk of seizures ., EVENING PRIMROSE OIL with Evening Having potent risk of seizures .,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • PDR for Herbal medicines. (2000) (4th ed.). U.S.
  • PDR for Herbal medicines. (2000) (4th ed.). U.S.

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20, , http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,

    ►   Route of Elimination :   Fecal, Renal,
    Ref :-   Book : Martindale    Page : 1065   Edition : 37,


    ►    Plasma Half-life :   Min value :-   75 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1065   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   3 hours,    Max value :-   5 hours,
    Ref :-   Book : Martindale    Page : 1065   Edition : 37,