Artemether and Lumefantrine is a Medicine belongs to antimalarial group whose information about Brand can be referenced from   Book : Martindale    Page : 657   Edition : 38,    Page :   Edition : ,

  ►   Brandname : Coartem,Riamet,Alither,Arh-L,Lumerax

  ►  Strength : Tablet with 20/120  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 935   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 651   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Uncomplicated falciparum malaria Oral Tablet Given as lumefantrine 480 mg with artemether 80 mg; 6 doses in total are given.

Ref :-  Book : Martindale    Page : 656   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Uncomplicated falciparum malaria 5-14 kg Oral
2 Uncomplicated falciparum malaria 15 to 24 kg Oral
3 Uncomplicated falciparum malaria 25 to 34 kg Oral
4 Uncomplicated falciparum malaria

Ref :- Book : Martindale    Page : 656   Edition : 38,
►  Side Effect : headache, Adults: anorexia, Dizziness, asthenia, arthralgia, myalgia., Children; fever, Cough, vomiting, loss of appetite,
Ref :-   Book : Goodman    Page : 1389   Edition : 12,

►  Drug Interaction : Drug interaction of Artemether and Lumefantrine is with Halofantrine, Quinine , Mefloquine , Amitriptyline , Clomipramine , Flecainide Acetate , Imipramine , Metoprolol ,
Ref :-   Book : Martindale    Page : 658   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Drugs that prolong QT interval (such as halofantrine, quinine, mefloquine). The combination is also considered contra-indicated by the cytochrome enzyme CYP2D6, particularly those with cardiac effects (including amitriptyline, clomipramine, flecainide, imipramine, and metoprolol).,
Ref :-   Book : Martindale    Page : 658   Edition : 37,


►  Contraindication : avoided in patients with serum-potassium or magnesium disturbances, severe heart failure, a family history of sudden cardiac death , any clinical condition known to prolong the QT interval, congenital long QT syndrome, symptomatic cardiac arrhythmia,
Ref :-   Book : Martindale    Page : 656   Edition : 38,
  ►  Mechanism of Action :   The mechanisms by which artemisinin-based combination therapies (ACTs) exert their antimalarial activity remain contentious. Nevertheless, most studies concur that the activity of artemisinin and its potent derivatives results from reductive scission of the peroxide bridge by reduced heme-iron, which is produced inside the highly acidic digestive vacuole (DV) of the parasite as it digests hemoglobin. ,
Ref :-   Book : Goodman    Page : 1395   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Neem with Another pathway,

  ►  Pathway with its reference as follows :-
  • Anti- malaria infection . --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan.,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Fecal, Hepatic (Metabolism),
    Ref :-   Book : Martindale    Page : 651   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   2-12 hrs for artemether,    Max value :-   4-6 day for lumefantrine,
    Ref :-   Book : Martindale    Page : 649,657   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   2-3 hrs for artemether,    Max value :-   6-8 hrs for lumefantrine,
    Ref :-   Book : Martindale    Page : 649,657   Edition : 38,