Artesunate is a Medicine belongs to antimalarial group whose information about Brand can be referenced from   Book : Martindale    Page : 652   Edition : 37,    Page :   Edition : ,

  ►   Brandname : Falcigo,Falcinil,Larinate,Larinate kit

  ►  Strength : Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 648   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV, IM, rectal,
Reference :-   Book : Martindale    Page : 651   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Malaria Oral 4 mg/kg o.d. used with other antimalarials and given for 3 days.
2 Severe malaria IM or IV 2.4 mg/kg Injection Repeated after 12 and 24 hrs and then given OD thereafter.

Ref :-  Book : Martindale    Page : 648   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Severe malaria IM or IV 2.4 mg/kg Injection

Ref :- Book : Martindale    Page : 649   Edition : 38,
►  Side Effect : haemolytic anaemia, bradycardia, potential neurotoxic effects,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 644   Edition : 3,

►  Drug Interaction : Drug interaction of Artesunate is with NA

  ►    Mechanism of Drug Drug Interaction :  ,
Ref :-   Book :    Page :    Edition : ,


►  Contraindication : Hypersensitivity,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 644   Edition : 3,
  ►  Mechanism of Action :   The mechanisms by which artemisinin-based combination therapies (ACTs) exert their antimalarial activity remain contentious. Nevertheless, most studies concur that the activity of artemisinin and its potent derivatives results from reductive scission of the peroxide bridge by reduced heme-iron, which is produced inside the highly acidic digestive vacuole (DV) of the parasite as it digests hemoglobin. ,
Ref :-   Book : Goodman    Page : 1395   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- with Another pathway,

  ►  Pathway with its reference as follows :-
  • Artmicinin and deoxyartemicinie have Anti-malerial property. --- (Bamunuarachchi, G. (2016). Antimalarial properties of Artemisia vulgaris L. ethanolic leaf extract in a Plasmodium berghei murine malaria model. J Vector Borne Dis, 278–284. )

  •   ►  URL -- http://www.mrcindia.org/journal/issues/504278.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Biliary, Hepatic (Metabolism),
    Ref :-   Book : Martindale    Page : 649   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   less than 1 hour,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 649   Edition : 38,