Aspirin is a Medicine belongs to Non Sterodial Anti- Inflammatory Drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 27   Edition : 38,    Page :   Edition : ,

  ►   Brandname : ASA,Colsprin,Caprin,Adprin-B,Storvas Trio-20,Deplatt A,Ecosprin AV,Aspro,Acesal,Bamyl,Ecosprin gold,Razel-A,Clopivas AP

  ►  Strength : Tablet (Enteric Coated) with 81  Mg, Tablet (Enteric Coated) with 165  Mg, Suppository with 120  Mg, Suppository with 200  Mg, Suppository with 300  Mg, Suppository with 600  Mg, Tablet (Extended Release Tablets) with 81  Mg, Tablet (Extended Release Tablets) with 650  Mg, Tablet (Extended Release Tablets) with 800  Mg, Tablet (Enteric Coated) with 325  Mg, Tablet (Enteric Coated) with 500  Mg, Tablet (Enteric Coated) with 650  Mg, Tablet (Enteric Coated) with 800  mg, Capsule with   , Tablet with 50  mg, Tablet with 75  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 655   Edition : 12, Martindale    Page : 27   Edition : 38,    Page :    Edition : ,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, rectal,
Reference :-   Book : Basic & Clinical pharmacology    Page : 655   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Analgesic and antipyretic Oral 300 900 mg Tablet Repeated every 4 to 6 hours according to clinical needs.
2 Acute rheumatic disorders Oral 4 8 gm Tablet Given daily in divided doses for both rheumatoid arthritis or osteoarthritis.
3 Antiplatelet therapy 40 80 mg Tablet Given daily.
4 Rheumatic fever 1 gm Tablet given every 4-6 hrs.
5 Rheumatic disorders Oral 5.4 gm Tablet Given daily in divided doses in chronic conditions.

Ref :-  Book : Martindale    Page : 25   Edition : 37, Goodman    Page : 966   Edition : 12,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Prophylaxis of stroke in high-risk children above 12 Years Oral 75 mg
2 Prophylaxis of stroke in high-risk children Oral 1 5 mg/kg o.d.
3 Risk of clot formation after cardiac surgery Oral 1 5 mg/kg o.d.
4 Risk of clot formation after cardiac surgery above 12 yrs Oral 75 mg

Ref :- Book : Martindale    Page : 25   Edition : 37,
Precaution :- If a Patient is using 'Aspirin' drug in  Ischemic Stroke  disease, then Please not to be given if large stroke present (involving more than 2/3rd of the MCA territory) .

Precaution :- If a Patient is using 'Aspirin' drug in  BERNARD-SOULIER SYNDROME  disease, then Please avoid all antiplatelet agents .

Precaution :- If a Patient is using 'Aspirin' drug in coronary heart disease disease, then Please not to be given   if he ever suffered from Intracranial Hemorrhage disease.
Precaution :- If a Patient is using 'Aspirin' drug in  thallasemia  disease, then Please Avoid .

Precaution :- If a Patient is using 'Aspirin' drug in  Acute Pancreatitis  disease, then Please do not use .

►  Side Effect : vertigo, Dizziness, Nervousness, tinnitus, Depression, drowsiness, insomnia, gastrointestinal disturbance, dyspepsia, nausea, vomiting, photosensitivity, haematemesis, melaena, gastrointestinal bleeding, Reye’s syndrome, anaemia,
Ref :-   Book : Martindale    Page : 21, 100   Edition : 37,

►  Drug Interaction : Drug interaction of Aspirin is with Antacid , , Carbonic anhydrase inhibitors , Alcohol, Coumarin Anticoagulant, sulfonylurea antidiabetic , , Diuretic Agents , Cardiac Glycosides, Angiotensin converting enzyme inhibitor, Beta Blockers , Quinolones, selective serotonin reuptake inhibitors, Selective nonadrenaline reuptake inhibitors, Bisphosphonates,  Ropinirole , Felbamate, Methotrexate, Tacrolimus , Dipyridamole , Metoclopramide , Metoprolol , Corticosteroids, Sildenafil , Zafirlukast , Phenytoin , Probenecid , Sulfinpyrazone, Fenbufen, Piroxicam , Zonisamide , Trifluoperazine , Flumazenil , Warfarin , Sertraline, Benzthiazide , Ketoprofen , Indomethacin , Cabergoline , Cyclosporine , Tenecteplase , Valproic acid(sodium valproate), Mifepristone , Ibuprofen , Lithium carbonate , Venlafaxine , Clopidogrel , Ticlopidine , Iloprost , Erlotinib, Sibutramine, Zidovudine, Ritonavir, Pentoxifylline ,
Ref :-   Book : Martindale    Page : 24   Edition : 37, Martindale    Page : 24, 103   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Some of the effects of aspirin on the gastrointestinal tract are enhanced by alcohol. Use of gold compounds with aspirin may exacerbate aspirin-induced liver damage. Interactions involving NSAIDs include enhancement of the effects of oral anticoagulants (especially by azapropazone and phenylbutazone) and increased plasma concentrations of lithium, methotrexate, and cardiac glycosides. The risk of nephrotoxicity may be increased if given with ACE inhibitors, ciclosporin, tacrolimus, or diuretics. There may also be an increased risk of hyperkalaemia with ACE inhibitors and some diuretics, including potassium sparing diuretics. The antihypertensive effects of some antihypertensives including ACE inhibitors, beta blockers, and diuretics may be reduced. Convulsions may occur due to an interaction with quinolones. NSAIDs may increase the effects of phenytoin and sulfonylurea antidiabetics. The risk of gastrointestinal bleeding and ulceration associated with NSAIDs is increased when used with corticosteroids, the SSRIs, the SNRI venlafaxine, the antiplatelets clopidogrel and ticlopidine, iloprost, erlotinib, sibutramine, or, possibly, alcohol, bisphosphonates, or pentoxifylline. There may be an increased risk of haematotoxicity if zidovudine is used with NSAIDs. Ritonavir may increase the plasma concentrations of NSAIDs. Use of aspirin with dipyridamole may result in an increase in plasma-salicylate concentrations. Drugs such as metoclopramide in patients with migraine headache result in earlier absorption of aspirin and higher peak plasma-salicylate concentrations. Metoprolol may also increase peak plasma-salicylate concentrations. Salicylate intoxication has occurred in patients on highdose salicylate regimens and carbonic anhydrase inhibitors. Plasma-salicylate concentrations may be reduced by corticosteroids. Also the risk of gastrointestinal bleeding and ulceration associated with aspirin is increased when used with corticosteroids. Antacids may increase the excretion of aspirin in alkaline urine. Aspirin may increase the activity of coumarin anticoagulants, sulfonylurea hypoglycaemic drugs, zafirlukast, methotrexate, phenytoin, and valproate. Aspirin diminishes the effects of uricosurics such as probenecid and sulfinpyrazone. The manufacturer of mifepristone advises of a theoretical risk that prostaglandin synthetase inhibition by aspirin or NSAIDs may alter the efficacy of mifepristone. Use of aspirin with other NSAIDs should be avoided because of the increased risk of adverse effects; the cardioprotective effects of aspirin may be abolished by ibuprofen and possibly other NSAIDS. Aspirin may decrease the plasma concentration of some other NSAIDs, for example, fenbufen, indometacin, and piroxicam.,
Ref :-   Book : Martindale    Page : 24, 103   Edition : 37,


►  Contraindication : Haemorrhagic disorder, Severe hepatic impairment, severe renal impairment, Haemophilia, to treat patients with gout, Pregnancy, patients with a history of sensitivity reactions to aspirin or other NSAIDs, Continuous prolonged use in the elderly, surgical procedures,
Ref :-   Book : Martindale    Page : 23   Edition : 37,
  ►  Mechanism of Action :   Inhibit cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), decreasing the biosynthesis of downstream eicosanoids and thereby limiting the inflammatory response.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 761   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Apple with same compound, Guava with same compound, Grapes with same compound, Willow Bark with same pathway,

  ►  Pathway with its reference as follows :-
  • Salicylate --- ((1985). Journal Of Americal Dietetic Association, 85(8). Retrieved from http://www.slhd.nsw.gov.au/rpa/Allergy/research/salicylatesinfoods.pdf )
  • Salicylate --- (: (1985). Journal Of Americal Dietetic Association, 85(8). Retrieved from http://www.slhd.nsw.gov.au/rpa/Allergy/research/salicylatesinfoods.pdf )
  • Salicylate --- ((1985). Journal Of Americal Dietetic Association, 85(8). Retrieved from http://www.slhd.nsw.gov.au/rpa/Allergy/research/salicylatesinfoods.pdf )
  • willow having salicin is metabolised to salicylic acid. --- (Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press. )

  •   ►  URL -- http://www.slhd.nsw.gov.au/rpa/Allergy/research/salicylatesinfoods.pdf, https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- FOLIC ACID with Reduces serum folate levels, IRON with increases iron losses from the digestive tract ., VITAMIN K with impairs vitamin metabolism ., VITAMIN C with Reduces vitamin C absorption , decreases uptake into leukocytes and levels in plasma and platelets , increases urinary excretion ., CAFFEINE with Dietary Substance is Drug Enhancer, CAPSCUCIN with Dietary Substance is Drug Inhibitor,

      ►  Reference :-
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Williamson, E. (2009). Stockley's Herbal Medicines Interaction .. London: Pharmacutical press.

  •   ►  URL -- http://197.14.51.10:81/pmb/AGROALIMENTAIRE/Handbook%20of%20Nutrition.pdf, https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20, https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- CAPSAICIN with Capsaicin alters gastric motility which reduces aspirin absorption and result in reduced salicylic acid level., MAKANDI with It contain coleus forskohlii could increase the effect of anti-platelet medicines such as aspirin , possibly leading to spontaneous bleeding ., BETANIN HCL with Increase the risk of bleeding , WILLOW BARK with Increase the risk of stomach bleeding, WILLOW BARK with Increase the risk of stomach bleeding, FISH OIL with Intensify the blood thinning effect of long aspirin use.Lead to internal or excessive bleeding . external , EVENING PRIMROSE OIL with INteract with antiplatelet drugs ., FEVER FEW with Fever few inhibit platelet aggregation & increase the risk o f bleeding .bg,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Williamson, E. (2009). Stockley's Herbal Medicines Interaction .. London: Pharmacutical press.
  • Williamson, E. (2009). Stockley's Herbal Medicines Interaction .. London: Pharmacutical press.

  •   ►  URL -- , http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf, https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20, https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf, https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf 2,

    ►   Route of Elimination :   Renal, breast milk, Hepatic (Metabolism),
    Ref :-   Book : Martindale    Page : 27   Edition : 38,


    ►    Plasma Half-life :   Min value :-   2 hours,    Max value :-   3 hours,
    Ref :-   Book : Martindale    Page : 24   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   NA
    Ref :-   Book : Goodman    Page : 966   Edition : 12,