Atazanavir is a Medicine belongs to Antiviral group whose information about Brand can be referenced from   Book : Martindale    Page : 969   Edition : 38,

  ►   Brandname : Reyataz,Atazor

  ►  Strength : Capsule with 100  Mg, Capsule with 150  Mg, Capsule with 300  Mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 888   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 956   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 HIV infection Oral 300 mg Capsule o.d. Given with 100 mg ritonavir; these doses for both treatment-naive and treatment-experienced patients.

Ref :-  Book : Martindale    Page : 968   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 HIV infection 6 Year above 6 year 15-24 kg Oral 150 mg o.d.
2 HIV infection 6 Year above 6 Years 25-31 kg Oral 200 mg o.d.
3 HIV infection 6 Year above 6 Years 32-38 kg Oral 250 mg o.d.
4 HIV infection 6 Year above 6 Years 39 kg or more Oral 300 mg o.d.
5 HIV infection From 13 Year At least 39 kg Oral 400 mg Capsule o.d.
6 HIV infection 6 Year above 6 yrs 25-31 kg Oral 200 mg o.d.
7 HIV infection 6 Year above 6 yrs 32-38 kg Oral 250 mg o.d.
8 HIV infection 6 Year above 6 yrs 39 kg or more Oral 300 mg o.d.

Ref :- Book : Martindale    Page : 956, 957.   Edition : 37, Martindale    Page : 956, 957   Edition : 37,
►  Side Effect : jaundice, diarrhea, nausea, headache, insomnia, abdominal pain, asthenia, fatigue, Rashes, Stevens-Johnson syndrome, erythema multiforme, Accumulation or redistribution of body fat including central obesity, dorsocervical fat enlargement (buffalo hump), peripheral wasting, facial wasting, breast enlargement, and cushingoid appearance, insulin resistance, Hyperlactataemia, asymptomatic elevations in unconjugated bilirubin, , nephrolithiasis, may prolong the PR interval of the ECG and asymptomatic first-degree AV block has been reported in some patients, hyperglycemia, myositis, myalgia, Elevated creatine phosphokinase, Immune reconstitution syndrome has been reported during the initial phase of treatment with combination antiretroviral therapy, in HIV-infected patients with severe immune deficiency, Ostenecrosis,
Ref :-   Book : Martindale    Page : 956, 957   Edition : 37, Nelson's textbook of Pediatrics    Page : 956, 957   Edition : 37,    Page :    Edition : ,

►  Drug Interaction : Drug interaction of Atazanavir is with , , , Proton pump inhibitor , ,  Ritonavir, Amiodarone , Bepridil, Quinidine , Astemizole, Terfenadine, Pimozide , dihydroergotamine, Ergotamine, Ergometrine , Methylergometrine, Cisapride , Triazolam , Simvastatin , Lovastatin , Flecainide Acetate , Propafenone, Efavirenz, Rifampicin , Irinotecan, Indinavir, Salmeterol, Alfuzosin , Sildenafil ,
Ref :-   Book : Martindale    Page : 956   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Atazanavir is extensively metabolised in the liver by the cytochrome P450 isoenzyme CYP3A4 and inhibits CYP3A4, CYP2C8, and UGT1A1. Use with drugs primarily metabolised by these isoenzymes may result in increases in their plasma concentrations, while drugs that inhibit CYP3A4 may increase atazanavir plasma concentrations. When ritonavir-boosted atazanavir is given, the drug interaction profile for ritonavir may predominate because ritonavir is a more potent CYP3A4 inhibitor than atazanavir. Atazanavir is contra-indicated with drugs that are highly dependent on CYP3A4 for clearance and for which elevated plasma concentrations are associated with serious or life-threatening events. These drugs include alfuzosin, antiarrhythmics (amiodarone, bepridil, flecainide, propafenone, and quinidine), antihistamines (astemizole and terfenadine), antineoplastic (irinotecan), ergot derivatives (dihydroergotamine, ergometrine, ergotamine, methylergometrine), gastrointestinal prokinetics (cisapride), antipsychotics (pimozide), sedatives and hypnotics (oral midazolam, triazolam), and statins (simvastatin and lovastatin). Owing to the potential for increased serum conc. of sildenafil, atazanavirshould be avoided with sildenafil when given at the doses needed for the treatment of pulmonary hypertension. Similarly, atazanavir may increase serum conc. of inhaled salmeterol and the combination is not recommended. Proton pump inhibitors, rifampicin, and St John’s wort decrease the concentration of atazanavir; use with the antiretroviral is not recommended due to possible loss of its activity and development of resistance. H2-receptor antagonists may also sudstantially reduce serum conc. of atazanavir; careful consideration needs to be given to both the size and timing of the H2-receptor antagonist dose when use with atazanavir is required. Atazanavir should also not be given to patients taking indinavir, as indirect hyperbilirubinaemia may result. Atazanavir is also contra-indicated with irinotecan as azatanavir’s inhibition of UGT1A1 may increase irinotecan toxicity.,
Ref :-   Book : Martindale    Page : 956   Edition : 37,


►  Contraindication : Severe hepatic impairment,
Ref :-   Book : Martindale    Page : 956   Edition : 37,
  ►  Mechanism of Action :   It is a selective, competitive, reversible inhibitor of HIV-1 protease. It interferes with the formation of essential viral proteins making them incapable of infecting other cells,
Ref :-   Book : Martindale    Page : 956,957   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- African potato with Another pathway,

  ►  Pathway with its reference as follows :-
  • Anti-HIV effect . --- (Mills, E., Cooper, C., Seely, D., & Kanfer, I. (2005). African herbal medicines in the treatment of HIV: Hypoxis and Sutherlandia. An overview of evidence and pharmacology. Nutrition Journal, 4(1). doi:10.1186/1475-2891-4-19 )

  •   ►  URL -- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1156943/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- CATS CLAY with Dietary Substance is Drug Enhancer,

      ►  Reference :-
  • Williamson, E. (2009). Stockley's Herbal Medicines Interaction .. London: Pharmacutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Faecal, Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 969   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   2.5 hours,
    Ref :-   Book : Martindale    Page : 956,957   Edition : 37,