Atomoxetine is a Medicine belongs to Selective nonadrenaline reuptake inhibitors group whose information about Brand can be referenced from   Book : Martindale    Page : 2318   Edition : 38,

  ►   Brandname : Strattera,Attentrol,Axepta

  ►  Strength : Capsule with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 2318   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 2350   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Attention deficit hyperactivity disorder Oral 40 100 mg Capsule Doses may be given as either a single dose in the morning or as equally divided doses in the morning and late afternoon or early evening.

Ref :-  Book : Martindale    Page : 2316,2317   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Attention deficit hyperactivity disorder 6 Year over 6 Years over 70 kg Oral 40 80 mg
2 Attention deficit hyperactivity disorder 6 Year over 6 Years 70 kg and below Oral 500 micrograms/kg

Ref :- Book : Martindale    Page : 2316, 2317   Edition : 38,
►  Side Effect : dyskinesia, gastrointestinal discomfort, insomnia, weight loss, headache, prolong QT interval , myocardial infarction, urinary retention, Somnolence, Dysmenorrhea, Xerostomia, suicidal thoughts, liver injury, stroke, sudden cardiac death,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 222   Edition : 3,

►  Drug Interaction : Drug interaction of Atomoxetine is with Monoamine Oxidase Inhibitor, , , ,  Salbutamol , paroxetine, Fluoxetine , Quinidine ,
Ref :-   Book : Martindale    Page : 2350   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Atomoxetine should not be taken with an MAOI, or within 2 weeks of stopping MAOI therapy, nor should MAOI therapy be started for 2 weeks after stopping atomoxetine. Care should be taken if given with other drugs that raise blood pressure, because of a possible additive affect; the actions of salbutamol on the cardiovascular system may be potentiated. In addition, there is a risk of cardiac events in patients receiving atomoxetine who are also taking drugs that affect cardiac conduction or electrolyte balance, or that inhibit the cytochrome P450 isoenzyme CYP2D6. Seizures have been noted with atomoxetine and caution is advised when used with drugs known to lower the seizure threshold. Atomoxetine is metabolised via the isoenzyme CYP2D6 and inhibitorsof this enzyme such as paroxetine, fluoxetine, and quinidine may increase plasma concentrations of atomoxetine in extensive, but not poor, metabolisers.,
Ref :-   Book : Martindale    Page : 2350   Edition : 37,


►  Contraindication : Hypersensitivity, narrow-angle glaucoma, concomitant use of MAO inhibitor,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 222   Edition : 3,
  ►  Mechanism of Action :   selectively block norepinephrine transporter, leading to increased norepinephrine levels,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 222   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Kava with same pathway,

  ►  Pathway with its reference as follows :-
  • norepinephrine reuptake inhibitor . --- ( Lakhan, S. & Vieira, K. (2010). Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review. Nutrition Journal, 9(1). doi:10.1186/1475-2891-9-42 )

  •   ►  URL -- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2959081/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Fecal, Renal, Hepatic (Metabolism),
    Ref :-   Book : Martindale    Page : 2350   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   5.2 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 2350   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   2 hours,
    Ref :-   Book : Martindale    Page : 2350   Edition : 37,