Atorvastatin is a Medicine belongs to Agent used in Dyslipidemia group whose information about Brand can be referenced from   Book : Martindale    Page : 1342   Edition : 37,    Page :   Edition : ,

  ►   Brandname : Atorlip,Atorva,Lipitor,Ecosprin Gold-20,Storvas Trio-20,Avas,Ecosprin AV,Sortis,Atocor, Artolip F, Atorvas, Avas,Ecosprin gold,Aztor,Storvas

  ►  Strength : Tablet with 10  Mg, Tablet with 20  Mg, Tablet with 40  Mg, Tablet with 80  Mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 633   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1342   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Hyperlipidaemias Oral 10 20 mg Tablet o.d. An initial dose of 40 mg daily may be used in patients who require a large reduction in LDL-cholesterol. The dose may be adjusted at intervals of 4 weeks up to a maximum of 80 mg daily.

Ref :-  Book : Martindale    Page : 1309   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Hypercholesterolaemia or combined hyperlipidaemia 10 Year 17 Year Oral 10 mg o.d.

Ref :- Book : Martindale    Page : 1342   Edition : 37,
Precaution :- If a Patient is using 'Atorvastatin' drug in mitral regurgitation disease, then Please use with caution   if he ever suffered from congestive heart failure disease.
Precaution :- If a Patient is using 'Atorvastatin' drug in mitral regurgitation disease, then Please   if he ever suffered from congestive heart failure disease.
Precaution :- If a Patient is using 'Atorvastatin' drug in acute kidney injury disease, then Please use with caution   if he ever suffered from MYOCARDIAL ISCHEMIA disease.
►  Side Effect : abdominal pain, constipation, diarrhea, nausea, headache, myopathy, rhabdomyolysis, hepatotoxicity, Dermatomyositis,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 330   Edition : 3,

►  Drug Interaction : Drug interaction of Atorvastatin is with HIV- protease inhibitors, ,  Cyclosporine , Itraconazole , Ketoconazole , Erythromycin , Clarithromycin , Telithromycin, Pioglitazone Hydrochloride , Nefazodone, Danazol, Amiodarone , Verapamil , Gemfibrozil ,
Ref :-   Book : Martindale    Page : 1528   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Atorvastatin is metabolised by the cytochrome P450 isoenzyme CYP3A4, as are simvastatin and lovastatin, and interactions may occur with drugs that inhibit this enzyme, including ciclosporin, itraconazole, ketoconazole, erythromycin, clarithromycin, telithromycin, HIV-protease inhibitors, nefazodone, danazol, amiodarone, and verapamil; there may also be a similar interaction with grapefruit juice. Raised plasma concentrations of simvastatin lovastatin, and atorvastatin. Grapefruit juice inhibits the cytochrome P450 isoenzyme CYP3A4 and studies using concentrated grapefruit juice have reported increased plasma concentrations of atorvastatin. Myopathy and rhabdomyolysis have been reported in patients receiving atorvastatin. increased plasma concentrations of atorvastatin when given with gemfibrozil.,
Ref :-   Book : Martindale    Page : 1528   Edition : 37,


►  Contraindication : Acute liver disease, unexplained persistently raised serum-aminotransferase concentrations, Pregnancy, statin should be stopped if creatine phosphokinase increases significantly or if myopathy is diagnosed,
Ref :-   Book : Martindale    Page : 1494   Edition : 38,
  ►  Mechanism of Action :   Inhibit HMG CoA reductase, the rate limiting enzyme in cholesterol synthesis→ LDL decreases upto 60%, HDL increases ~ 10% , triglycerides decreases upto 40% .,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 330   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Garlic with same pathway, Angeer with Another pathway,

  ►  Pathway with its reference as follows :-
  • HMG-COA reductase inhibitor --- (18. PDR for Herbal medicines. (2000) (4th ed.). U.S. )
  • Hypolipidemic effect. --- (Joseph, Baby. "Pharmacognostic And Phytochemical Properties Of Ficus Carica Linn –An Overview". International Journal of PharmTech Research 3.1 (2017): 08-12,. Print. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf, http://sphinxsai.com/Vol.3No.1/pharm_jan-mar11/pdf/JM11(%20PT=03)%2008-12.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- VITAMIN A with Dietary Substance is Drug Inhibitor, NIACIN with Dietary Substance is Drug Enhancer, CO Q10 with Decrease in Nutrient Level, GRAPE FRUIT with Grape fruit juice contain naringenin may inhibit the cytochrome P 450 isoenzyme CYP344, the main route of metabolism of statin that can much result in higher level of drug in the blood stream, and longer persistence of the drug., IRON with Dietary Substance is Drug Inhibitor, ST JOHNS WORT with Dietary Substance is Drug Inhibitor,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf, , https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- GRAPE FRUIT with Grapefruit contains substances that may inhibit the body ability to break down atorvastatin ; consuming grapefruit or grapefruit juice might therefore increase the potential toxicity of the drug ., COQ10 with Impairs coenzyme Q10 metabolism .,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf, http://197.14.51.10:81/pmb/AGROALIMENTAIRE/Handbook%20of%20Nutrition.pdf,

    ►   Route of Elimination :   Biliary, Hepatic (Metabolism),
    Ref :-   Book : Martindale    Page : 1342   Edition : 37,


    ►    Plasma Half-life :   Min value :-   14 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1342   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,