Atovaquone is a Medicine belongs to Antiprotozoals group whose information about Brand can be referenced from   Book : Martindale    Page : 929   Edition : 38, Martindale    Page : 929   Edition : 38,

  ►   Brandname : Mepron,Wellvone,Samtirel

  ►  Strength : Suspension with 750  mg/5mL,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 935   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 915   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Prophylaxis of falciparum malaria Oral 250 mg o.d. For adults weighing over 40 kg; given along with proguanil. The course should start 1 to 2 days before travel to the malarious area, continue daily throughout exposure.
2 Treatment of uncomplicated falciparum malaria Oral 1 gm Suspension o.d. Treatment given with proguanil for 3 days. For adults weighing over 40 kg.
3 Treatment of mild to moderate pneumocystis pneumonia Oral 750 mg Suspension b.d. Given with food; for 21 days.

Ref :-  Book : Martindale    Page : 916   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Prophylaxis of falciparum malaria more than 10 to 20 kg Oral 62.5 mg Tablet o.d.
2 Prophylaxis of falciparum malaria From 5 to 8 kg Oral Tablet
3 Prophylaxis of falciparum malaria more than 8 to 10 kg Oral Tablet
4 Prophylaxis of falciparum malaria more than 10 to 20 kg Oral 62.5 mg Tablet o.d.
5 Prophylaxis of falciparum malaria more than 20 to 30 kg Oral 125 mg Tablet o.d.
6 Prophylaxis of falciparum malaria more than 30 to 40 kg Oral 187.5 mg Tablet o.d.
7 Prophylaxis of falciparum malaria more than 40 kg Oral 250 mg Tablet o.d.
8 Treatment of uncomplicated falciparum malaria From 5 to 8 kg Oral 125 mg Tablet o.d.
9 Treatment of uncomplicated falciparum malaria more than 8 to 10 kg Oral 187.5 mg Tablet o.d.
10 Treatment of uncomplicated falciparum malaria more than 10 to 20 kg Oral 250 mg Tablet o.d.
11 Treatment of uncomplicated falciparum malaria more than 20 to 30 kg Oral 500 mg Tablet
12 Treatment of uncomplicated falciparum malaria more than 30 to 40 kg Oral 750 mg Tablet
13 Treatment of uncomplicated falciparum malaria more than 40 kg Oral 1000 mg Tablet

Ref :- Book : Goodman    Page : 1387, 1389   Edition : 12,
Precaution :- If a Patient is using 'Atovaquone' drug in  Malaria  disease, then Please be avoided in patients of renal impairmen .

►  Side Effect : headache, coughing, nausea, diarrhea, vomiting, anorexia, Depression, Dizziness, fever, insomnia, Skin rashes, raised liver enzyme values, hyponatraemia, anaemia, neutropenia, allergic reactions, haematological disturbances, gastrointestinal effects, ,
Ref :-   Book : Martindale    Page : 915   Edition : 37,    Page :    Edition : ,

►  Drug Interaction : Drug interaction of Atovaquone is with Antidiarrheal , BENZODIAZEPINES , Cephalosporin , Laxative , Opoids,  Metoclopramide , Tetracycline , Rifampicin , Rifabutin , Aciclovir , Paracetamol , Zidovudine, Indinavir, Sulfamethoxazole and Trimethoprim (Co-trimoxazole),
Ref :-   Book : Martindale    Page : 915   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Use of atovaquone with either metoclopramide, tetracycline, or rifampicin (and possibly also rifabutin) may result in decreases in plasma-atovaquone concentrations. Other drugs which have produced small reductions in plasma-atovaquone concentrations include aciclovir, antidiarrhoeals, benzodiazepines, cephalosporins, laxatives, opioids, and paracetamol. Atovaquone is reported to decrease the metabolism of zidovudine resulting in moderate increases in zidovudine plasma concentrations. A decrease in trough concentrations of indinavir, and in the area under the indinavir time-concentration curve has been reported when atovaquone was also given. Small decreases in the plasma concentrations of co-trimoxazole have been noted in patients taking atovaquone. ,
Ref :-   Book : Martindale    Page : 915   Edition : 37,


►  Contraindication : Hypersensitivity,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 645   Edition : 3,
  ►  Mechanism of Action :   Atovaquone acts selectively on the mitochondrial cytochrome bc1 complex to inhibit electron transport and collapse the mitrochondrial membrane potential. The primary function of mitrochondrial electron transport in P.falciparum is to regenerate ubiquinone, which is the electron acceptor for parasite dihydroorotate dehydrogenase, an enzyme essential for pyrimidine biosynthesis in the parasite. ,
Ref :-   Book : Goodman    Page : 1398   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Cincona bark with Another pathway,

  ►  Pathway with its reference as follows :-
  • Quinine & quinidine have Anti-malerial property. --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://www.vitorrentz.in/search/Text+Book+Of+Pharmacognosy, +C.+K.+Kokate, +A.P.+Purohit, +S.B.+Gokhale,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Fecal,
    Ref :-   Book : Martindale    Page : 916   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   2,    Max value :-   3 days,
    Ref :-   Book : Martindale    Page : 929   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA