Atracurium is a Medicine belongs to Neuromuscular blocker group whose information about Brand can be referenced from   Book : Martindale    Page : 2034   Edition : 38, Martindale    Page : 2034   Edition : 38,

  ►   Brandname : Tracrium,Nimbex,Acris,Artacil

  ►  Strength : Injection with 10  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 481   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV,
Reference :-   Book : Martindale    Page : 2069   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Neuromuscular blocker IV 300 600 micrograms/kg Injection Given here is general dose range. Used for endotracheal intubation and to provide muscle relaxation in general anaesthesia for surgical procedures and to aid controlled ventilation.

Ref :-  Book : Martindale    Page : 2030   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Neuromuscular blocker over 1 Month IV 300 600 micrograms/kg Injection

Ref :- Book : Martindale    Page : 2030   Edition : 38,
Precaution :- If a Patient is using 'Atracurium' drug in  MYASTHENIA GRAVIS  disease, then Please Use with caution .

►  Side Effect : tachycardia, reduction in blood pressure, reduces gastrointestinal motility, reduction in gastrointestinal tone, Histamine release may lead to wheal-and-flare effects at the site of injection, flushing, occasional bronchospasm, ,
Ref :-   Book : Martindale    Page : 2030   Edition : 38,

►  Drug Interaction : Drug interaction of Atracurium is with Anticholinesterase, ,  NA

  ►    Mechanism of Drug Drug Interaction :  Some drugs may influence neuromuscular transmission and thus interfere with the action of both competitive and depolarising neuromuscular blockers, resulting in potentiation or antagonism of neuromuscular block. Some interactions may be advantageous, such as the reversal of competitive neuromuscular block by anticholinesterases. In general, adverse interactions are potentially more serious in patients with impaired neuromuscular function.,
Ref :-   Book : Martindale    Page : 2031   Edition : 38,


►  Contraindication : respiratory insufficiency or pulmonary disease , dehydrated or severely ill patient,
Ref :-   Book : Martindale    Page : 2031   Edition : 38,
  ►  Mechanism of Action :   It act by competing with acetylcholine for receptors on the motor end-plate of the neuromuscular junction to produce blockade.,
Ref :-   Book : Martindale    Page : 2030   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Kava with same pathway,

  ►  Pathway with its reference as follows :-
  • Kava root contains kava lactones it act as skeletal muscle relaxation . --- (Williams, M. (2006). Dietary Supplements and Sports Performance: Herbals. Journal Of The International Society Of Sports Nutrition, 3(1), 1. doi:10.1186/1550-2783-3-1-1 )

  •   ►  URL -- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2129138/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal, Biliary,
    Ref :-   Book : Martindale    Page : 2030   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   20 min,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 2030   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA