Atropine is a Medicine belongs to anticholinergic group whose information about Brand can be referenced from   Book : Martindale    Page : 1313   Edition : 38,

  ►   Brandname : AtroPen,Atp,Atro,Atropt,Dysurgal,Di Shan

  ►  Strength : Tablet with 0.4  Mg, Injection with 0.05  mg/ml, Injection with 0.1  mg/ml, Injection with 0.3  mg/ml, Injection with 0.4  mg/ml, Injection with 0.5  mg/ml, Injection with 0.8  mg/ml, Injection with 1  mg/ml, Eye Drop with 0.5  %, Eye Drop with 1  %, Eye ointment with 1  %, Eye Drop with 2  %, Eye ointment with 0.5  %, Tablet with 0.6  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 127,1111   Edition : 12, Basic & Clinical pharmacology    Page : 127.1111   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IM, IV, intra-ocular injection, Topical,
Reference :-   Book : Martindale    Page : 1344   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Premedication s.c/ i.m 300 600 micrograms Injection 30 to 60 minutes before anaesthesia.
2 Intra-operative bradycardia IV 300 600 micrograms Injection larger doses may be used in emergencies.
3 Counteract the muscarinic effects of anticholinesterases IV 0.6 1.2 mg Injection Given before or with the anticholinesterase.
4 Inflammatory disorders of the eye Topical 1 % Eye Drop 1 or 2 drops of solution applied to the eye(s) 1 to 4 times daily.

Ref :-  Book : Martindale    Page : 1344,1345   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Premedication before anaesthesia upto 3 kg s.c/ i.m 100 micrograms Injection
2 Premedication before anaesthesia 7 to 9 kg s.c/ i.m 200 micrograms Injection
3 Premedication before anaesthesia 12 to 16 kg s.c/ i.m 300 micrograms Injection
4 Premedication before anaesthesia s.c/ i.m Injection
5 Intra-operative bradycardia 10 20 micrograms/kg
6 Counteract the muscarinic effects of anticholinesterases IV 20 micrograms/kg Injection

Ref :- Book : Martindale    Page : 1344-1345   Edition : 37,
►  Side Effect : cardiac arrhythmia, coma, respiratory depression, raised intra-ocular pressure, tachycardia, constipation, Xerostomia, Blurred Vision,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 130   Edition : 3,

►  Drug Interaction : Drug interaction of Atropine is with , Phenothiazine antipsychotics, Tricyclic antidepressants, Monoamine Oxidase Inhibitor, ,  Amantadine , Cocaine , Acarbose , Cisapride , Domperidone , Metoclopramide ,
Ref :-   Book : Martindale    Page : 1344   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  The effects of atropine and other antimuscarinics may be enhanced by use with other drugs having antimuscarinic properties, such as amantadine, some antihistamines, phenothiazine antipsychotics, and tricyclic antidepressants. Inhibition of drug-metabolising enzymes by MAOIs may possibly enhance the effects of antimuscarinics. The reduction in gastric motility caused by antimuscarinics may affect the absorption of other drugs. Antimuscarinics may also antagonise the gastrointestinal effects of cisapride, domperidone, and metoclopramide. Antimuscarinics and parasympathomimetics may counteract each others effects,
Ref :-   Book : Martindale    Page : 1343   Edition : 37,


►  Contraindication : paralytic ileus, prostatic enlargement, Myasthenia gravis, infants aged less than 3 months, pyloric stenosis, narrow-angle glaucoma,
Ref :-   Book : Martindale    Page : 1343   Edition : 37,
  ►  Mechanism of Action :   Atropine is a tertiary amine antimuscarinic alkaloid with both central and peripheral actions. It is usually given as the sulfate. It first stimulates and then depresses the CNS and has antispasmodic actions on smooth muscle and reduces secretions, especially salivary and bronchial secretions; it also reduces perspiration, but has little effect on biliary or pancreatic secretion. Atropine depresses the vagus and thereby increases the heart rate.,
Ref :-   Book : Martindale    Page : 1344   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Atropa belladonna with same compoundAnother pathwaysame pathway, Atropa belladonna with same compoundAnother pathwaysame pathway, Atropa belladonna with same compoundAnother pathwaysame pathway,

  ►  Pathway with its reference as follows :-
  • Atropine --- ( Rajput, H. (2014). Effects of Atropa belladonna as an Anti-Cholinergic. Nat Prod Chem Res 2014, 1(1). )
  • atropen is a competitive antagonist for the muscarinic acetylcholine receptor types M1, M2, M3, M4 and M5. --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )
  • Atropine --- ( Rajput, H. (2014). Effects of Atropa belladonna as an Anti-Cholinergic. Nat Prod Chem Res 2014, 1(1). )
  • Atropine --- ( Rajput, H. (2014). Effects of Atropa belladonna as an Anti-Cholinergic. Nat Prod Chem Res 2014, 1(1). )
  • atropen is a competitive antagonist for the muscarinic acetylcholine receptor types M1, M2, M3, M4 and M5. --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )
  • Atropine --- ( Rajput, H. (2014). Effects of Atropa belladonna as an Anti-Cholinergic. Nat Prod Chem Res 2014, 1(1). )
  • Atropine --- ( Rajput, H. (2014). Effects of Atropa belladonna as an Anti-Cholinergic. Nat Prod Chem Res 2014, 1(1). )
  • atropen is a competitive antagonist for the muscarinic acetylcholine receptor types M1, M2, M3, M4 and M5. --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )
  • Atropine --- ( Rajput, H. (2014). Effects of Atropa belladonna as an Anti-Cholinergic. Nat Prod Chem Res 2014, 1(1). )

  •   ►  URL -- http://www.esciencecentral.org/journals/effects-of-atropa-belladonna-as-an-anti-cholinergic-2329-6836.1000104.pdf, http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- IRON with Decrease in Nutrient Level,

      ►  Reference :-
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart

  •   ►  URL -- http://197.14.51.10:81/pmb/AGROALIMENTAIRE/Handbook%20of%20Nutrition.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- MELATONIN with may cause excessive drowsiness when taken with drug., KAVA with May cause excessive drowsiness when taken with drug., VALERIN with May cause excessive drowsiness when taken with drug., GREEN TEA with Containing high amount of tannins which may interfere with the absorption of atropine taken by mouth ., BLACK TEA with Containing high amount of tannins which may interfere with the absorption of atropine taken by mouth ., BETAL PALM with Increasing anticholinergic activity of tricyclic antidepressants .,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand.
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press.
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press.
  • Duke, J. (2002). Handbook of Medicinal Herbs (2nd ed.). Boca Raton London New York Washington ,D.C.

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20, http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf, http://www.crcnetbase.com/doi/pdf/10.1201/9781420040463.fmatt,

    ►   Route of Elimination :   Hepatic (Metabolism), Renal, breast milk,
    Ref :-   Book : Martindale    Page : 1344   Edition : 37,


    ►    Plasma Half-life :   Min value :-   4 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1344   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,