Azelastine is a Medicine belongs to antihistamines group whose information about Brand can be referenced from   Book : Martindale    Page : 618   Edition : 37,

  ►   Brandname : Azep,Aller-Eze,Optilast,Allergodil,Astelin,Eyezep

  ►  Strength : Nasal Spray with 137  mcg/puff, Ophthalmic Solution with 0.5  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 292   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Topical, intranasal, Oral,
Reference :-   Book : Basic & Clinical pharmacology    Page : 292   Edition : 12, Basic & Clinical pharmacology    Page : 618   Edition : 12, Martindale    Page : 618   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Allergic rhinitis nasal 140 micrograms Spray b.d. in each nostril.
2 Non-allergic rhinitis nasal 274 micrograms Spray i.e 2 spray into each nostril twice daily.
3 Conjunctivitis Topical 0.05 % Solution b.d. It is instilled into each eye.

Ref :-  Book : Martindale    Page : 618   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Allergic rhinitis 5 Year and over nasal 140 micrograms Spray b.d.
2 Non-allergic rhinitis 12 Year and over nasal 274 micrograms Spray
3 Conjunctivitis Topical 0.05 % Eye Drop

Ref :- Book : Martindale    Page : 618   Edition : 37,
►  Side Effect : nausea, vomiting, diarrhea, Somnolence, headache, dry mouth, Rashes, hypersensitivity reactions, bronchospasm, angioedema, anaphylaxis, taste disturbances, epigastric pain, , CNS depression,
Ref :-   Book : Martindale    Page : 611, 618   Edition : 37,    Page :    Edition : , Martindale    Page : 611,618   Edition : 37,

►  Drug Interaction : Drug interaction of Azelastine is with NA

  ►    Mechanism of Drug Drug Interaction :  ,
Ref :-   Book :    Page :    Edition : ,


►  Contraindication : Acute alcoholism, Alcohol, CNS depressant,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 775   Edition : 3,
  ►  Mechanism of Action :   Inverse agonists that bind preferentially to the inactive conformation of the H1 receptor and shift the equilibrium toward the inactive receptor state.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 775   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Onion with Another pathway,

  ►  Pathway with its reference as follows :-
  • Onion having active constituent quercetin which act as antihistamine . --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Fecal, Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 618   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   25 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 618   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   4 hours,    Max value :-   5 hours,
    Ref :-   Book : Martindale    Page :    Edition : 37,