Azilsartan is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book :    Page :   Edition :    Martindale    Page : 1313   Edition : 38  

  ►   Brandname : Ziltax, Edarbi, Azilva
  ►  Strength : Tablet with 40 mg.  Tablet with 80 mg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 190   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 1313   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Hypertension Oral Tablet A starting dose corresponding to azilsartan medoxomil 40 mg is given once daily. A starting dose of 20 mg once daily may be considered necessary in patients over 75 years of age, who can be at risk of hypotension, & in patients with volume or salt depletion.

Ref :-  Book : Martindale    Page : 1313   Edition : 38  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Adverse effects reported to be usually mild and transient including, Dizziness, Headache, Dose-related orthostatic hypotension., Impaired renal function, Hyperkalaemia, Myalgia, Arthralgia, Respiratory-tract disorders, Back pain, Gastrointestinal disturbances, Fatigue, Neutropenia
Ref :-   Book : Martindale    Page : 1313,1424   Edition : 38.      Page :    Edition : .  

►  Drug Interaction : Drug interaction of Azilsartan is with , , Potassium -Sparing Diuretics , , NONSTEROIDAL ANTI-INFLAMMATORY DRUGS, Angiotensin converting enzyme inhibitor, ,  Aliskiren Fumarate
Ref :-   Book : Martindale    Page : 1313,1424   Edition : 38.  

  ►    Mechanism of Drug Drug Interaction :  The antihypertensive effects of azilsartan may be potentiated by drugs or other agents that lower blood pressure. An additive hyperkalaemic effect is possible with potassium supplements, potassium-sparing diuretics, or other drugs that can cause hyperkalaemia; azilsartan and potassium-sparing diuretics should not generally be given together. NSAIDs should be used with caution in patients taking azilsartan as the risk of renal impairment may be increased, particularly in those who are inadequately hydrated; use of NSAIDs may also attenuate the hypotensive effect of azilsartan. The use of azilsartan with an ACE inhibitor may increase the risk of hyperkalaemia, hypotension, and syncope, particularly in patients with atherosclerotic disease or heart failure, or in diabetics who have end-organ damage. Addionally, the use of angiotensin II receptor antagonists with the renin inhibitor aliskiren is not generally recommended, and should be avoided in some patients. Azilsartan and some other angiotensin II receptor antagonists are metabolised by cytochrome P450 isoenzymes and interactions may occur with drugs that affect these enzymes.
Ref :-   Book : Martindale    Page : 1313,1424   Edition : 38.  

►  Contraindication : Pregnancy, Severe hepatic impairment
Ref :-   Book : Martindale    Page : 1313,1424   Edition : 38.  
  ►  Mechanism of Action :   It is an angiotensin II receptor antagonist with actions similar to those of Losartan.
Ref :-   Book : Martindale    Page : 1313   Edition : 38.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

DIETARY Substance Interactions

​   ► This Medicine interact with :- NA

ContraIndication DIETARY Substance

​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   NA

►    Plasma Half-life :   Min value :-   Elimination Half life; 11 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 1313   Edition : 38.  

►    Peak Plasma Concentration :   Min value :-   1.5,    Max value :-   3 hours.  
Ref :-   Book : Martindale    Page : 1313   Edition : 38.