Azithromycin is a Medicine belongs to Macrolide antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 223   Edition : 38,    Page :   Edition : ,

  ►   Brandname : Azee,Azibact,Zithromax,Zmax,Azith,A Sai Qi,Azithrobeta,Zithromac,A-Z

  ►  Strength : Capsule with 250  Mg, Capsule with 500  Mg, Capsule with 600  Mg, Oral Suspension with 100  mg/5mL, Oral Suspension with 200  mg/5mL, Injection with 500  Mg, Tablet with   , Eye Drop with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 819   Edition : 12, Martindale    Page : 223   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV, Topical,
Reference :-   Book : Martindale    Page : 221   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Chancroid Oral 1 gm Capsule It is given as a single dose. This dose used for uncomplicated genital infections caused by Chlamydia trachomatis and for chancroid.
2 Uncomplicated gonorrhoea Oral 1 gm Capsule This single dose given with a single dose of cephalosporin.
3 Granuloma inguinale Oral 1 gm Capsule Which is followed by 500 mg daily.
4 Community acquired pneumonia IV infusion 500 mg Injection Also this equivalent dose is applicable for pelvic inflammatory disease; given as a single daily dose.
5 Prophylaxis of disseminated MAC infections 1.2 gm it is given once weekly.
6 Treatment or secondary prophylaxis of disseminated MAC infections 500 600 mg o.d. given with other antimycobacterials.
7 Conjunctivitis Topical 1 1.5 % Eye Drop caused by susceptible strains of bacteria.
8 Trachomatous conjunctivitis Topical 1.5 % Ophthalmic Solution

Ref :-  Book : Martindale    Page : 221   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Acute Otitis Media 30 mg/kg
2 Pharyngitis over 2 Year Oral 12 mg/kg Suspension o.d.
3 Tonsillitis over 2 Year Oral 12 mg/kg Suspension o.d.
4 Treatment of disseminated MAC infections 10 12 mg/kg o.d.
5 Prophylaxis of disseminated MAC infections 5 mg/kg o.d.
6 Prevention of secondary cases of group A streptococcal infection 6 Month over 6 months Oral 12 mg/kg Suspension o.d.
7 Mild to moderate typhoid 6 Month over 6 months 10 mg/kg o.d.
8 Chronic Cystic fibrosis by P. aeruginosa 25-40 kg Oral 250 mg Suspension
9 Chronic P. aeruginosa infection in Cystic fibrosis over 40 kg Oral 500 mg Suspension

Ref :- Book : Martindale    Page : 221   Edition : 38,
Precaution :- If a Patient is using 'Azithromycin' drug in  MYASTHENIA GRAVIS  disease, then Please Use with caution .

►  Side Effect : gastrointestinal disturbance, headache, Somnolence, taste disturbances, muscle weakness, pain and swelling at the site of injection, , myasthenic syndrome,
Ref :-   Book : Martindale    Page : 222   Edition : 38,    Page :    Edition : ,

►  Drug Interaction : Drug interaction of Azithromycin is with Oral Contraceptive,  Digoxin , Cyclosporine , Astemizole, Cisapride , Terfenadine, Spiramycin , Levodopa ,
Ref :-   Book : Martindale    Page : 222,294   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Azithromycin with antacids containing aluminium or magnesium salts can reduce the rate, but not the extent, of its absorption. Macrolides-induced inhibition of metabolism can result in severe adverse effects, including ventricular arrhythmias with astemizole, cisapride, and terfenadine. Macrolides themselves have been reported rarely to prolong the QT interval and should be used with caution with other drugs known to also have this effect. Macrolides cause suppression of the gastrointestinal flora responsible for the intraluminal metabolism of digoxin and possibly oral contraceptives, and the stimulant effect of macrolides on gastrointestinal motility which is believed to be responsible for the interaction between spiramycin and levodopa. An alternative mechanism by which macrolides increase serum concentrations of digoxin is thought to be via the inhibition of intestinal or renal P-glycoprotein transport of digoxin. ,
Ref :-   Book : Harrison's principles of internal medicine    Page : 222,294   Edition : 38,


►  Contraindication : Severe hepatic impairment,
Ref :-   Book : Martindale    Page : 222   Edition : 38,
  ►  Mechanism of Action :   Azithromycin is a bacteriostatic agent that inhibit protein synthesis by binding reversibly to 50S ribosomal subunits of sensitive microorganisms, at or very near the site that binds chloramphenicol. ,
Ref :-   Book : Goodman    Page : 1530   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Garlic with Another pathway,

  ►  Pathway with its reference as follows :-
  • Garlic having active constituent Allicin which act as antibiotic . --- (Effects of ginger (Zingiber officinale Roscoe) and garlic (Allium sativum L.) on rats infected with Kleibsiella pneumoniae. (2009). The Internet Journal Of Alternative Medicine, 7(1). doi:10.5580/27c2 )

  •   ►  URL -- file:///C:/Users/dr.%20lonch/Downloads/1-4-34.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- MAGNESIUM with Dietary Substance is Drug Inhibitor,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press.

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- PHYLLIUM with Make antibiotics less effective, medicine form salt with polyvalent metal (antacid).,

      ►  Reference :-
  • PDR for Herbal medicines. (2000) (4th ed.). U.S.

  •   ►  URL -- ed.). U.S. http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,

    ►   Route of Elimination :   Biliary, Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 224   Edition : 37,


    ►    Plasma Half-life :   Min value :-   68 hrs,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 223   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   2 hrs,    Max value :-   3 hrs,
    Ref :-   Book : Martindale    Page : 223   Edition : 38,