Baclofen is a Medicine belongs to Muscle relaxants group whose information about Brand can be referenced from   Book : Martindale    Page : 2017   Edition : 38, Martindale    Page : 2017   Edition : 38,

  ►   Brandname : Gablofen,Lioresal,baclan,bacmax,Clofen,Zufen

  ►  Strength : Tablet with 10  Mg, Tablet with 20  Mg, Injection with 0.05  mg/ml, Injection with 0.5  mg/ml, Injection with 1  mg/ml, Oral solution with   , Oral Suspension with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 481   Edition : 12, Martindale    Page : 2053   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, intrathecal ,
Reference :-   Book : Martindale    Page : 2052   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Severe chronic spasticity associated with a variety of conditions Oral 15 mg Tablet given in divided doses.

Ref :-  Book : Martindale    Page : 2052   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Severe chronic spasticity associated with a variety of conditions Oral 300 micrograms/kg Oral solution
2 Severe chronic spasticity associated with a variety of conditions

Ref :- Book : Martindale    Page : 2052   Edition : 37,
Precaution :- If a Patient is using 'Baclofen' drug in  Generalized, Tonic-Clonic Seizures  disease, then Please Not to be given .

►  Side Effect : coma, Somnolence, constipation, seizure, and death after abrupt withdrawal,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 184   Edition : 3,

►  Drug Interaction : Drug interaction of Baclofen is with Tricyclic antidepressant , Alcohol, CNS depressant, Antihypertensive Agents ,  Ibuprofen , Lithium carbonate ,
Ref :-   Book : Martindale    Page : 2052   Edition : 37, Martindale    Page : 2051   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Alcohol and other CNS depressants may exacerbate the CNS effects of baclofen and should be avoided; severe aggravation of hyperkinetic symptoms may possibly occur in patients taking lithium. There may be increased weakness if baclofen is given to patients taking a tricyclic antidepressant and there may be an increased hypotensive effect if it is given to patients receiving antihypertensive therapy. Ibuprofen and other drugs that produce renal insufficiency may reduce baclofen excretion leading to toxicity,
Ref :-   Book : Martindale    Page : 2052   Edition : 37,


►  Contraindication : patients affected should not drive or operate machinery, Active peptic ulcer disease,
Ref :-   Book : Martindale    Page : 2051   Edition : 37,
  ►  Mechanism of Action :   Baclofen, an analogue of gamma-aminobutyric acid, is a centrally acting skeletal muscle relaxant. It interferes with the release of excitatory neurotransmitters and inhibits monosynaptic and polysynaptic transmission at the spinal cord level. It may also act at supraspinal sites producing CNS depression,
Ref :-   Book : Martindale    Page : 2052   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Baloon flower with Another pathway,

  ►  Pathway with its reference as follows :-
  • CNS depressant --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- THIAMINE with Dietary Substance is Drug Enhancer,

      ►  Reference :-
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- KAVA with May cause excessive drawsinesss when taken with muscle relaxcent .,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand.

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,

    ►   Route of Elimination :   Hepatic (Metabolism), Renal, breast milk,
    Ref :-   Book : Martindale    Page : 2052   Edition : 37,


    ►    Plasma Half-life :   Min value :-   3 hours,    Max value :-   4 hours,
    Ref :-   Book : Martindale    Page : 2052   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   0.5 hours,    Max value :-   3 hours,
    Ref :-   Book : Martindale    Page : 2052   Edition : 37,