Benoxinate/ Oxybuprocaine Hydrochloride is a Medicine belongs to Local anaesthetics group whose information about Brand can be referenced from   Book : Martindale    Page : 2029   Edition : 37   Martindale    Page : 2029   Edition : 37  

  ►   Brandname : Novesine, Oxyben, Fluorox, Flurox
  ►  Strength : Ophthalmic Solution with .  Eye Drop with

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 2029   Edition : 37  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Topical
Reference :-   Book : Martindale    Page : 2029   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Surface anaesthesia in ophthalmological procedures Topical 0.4 % Ophthalmic Solution
2 Surface anaesthesia of the ear, nose, and throat Topical 1 % Solution

Ref :-  Book : Martindale    Page : 2029   Edition : 37  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Restlessness, Excitement, Nervousness, Paraesthesia, Dizziness, Tinnitus, Blurred Vision, Nausea, Vomiting, Muscle twitching, Tremor, Convulsion, Fetal intoxication, Hypotension, Vertigo, Nystagmus, Fibrinous iritis, Moderate cornial swelling
Ref :-   Book : Martindale    Page : 2011, 2029   Edition : 37.      Page :    Edition : .  

►  Drug Interaction : Drug interaction of Benoxinate/ Oxybuprocaine Hydrochloride is with anticholinesterases, Aminosalicylic Acid, Sulfonamide , , , , Tricyclic antidepressants,  Phenoxybenzamine , Aminosalicylic acid, Suxamethonium chloride
Ref :-   Book : Martindale    Page : 2013   Edition : 37.  

  ►    Mechanism of Drug Drug Interaction :  The metabolism of ester-type local anaesthetics may be inhibited by anticholinesterases, increasing the risk of systemic toxicity. Ester derivatives such as tetracaine, benzocaine, or procaine that are hydrolysed to para-aminobenzoic acid may antagonise the activity of aminosalicylic acid or sulfonamides. Ester-type local anaesthetics such as procaine and cocaine that are hydrolysed by plasma cholinesterase may competitively enhance the neuromuscular blocking activity of suxamethonium. If local anaesthetics containing adrenaline are given for epidural or paracervical block during labour the use of an oxytocic drug post partum may lead to severe hypertension. Although there is no clinical evidence of dangerous interactions between adrenaline-containing local anaesthetics and MAOIs or tricyclic antidepressants, great care should nevertheless be taken to avoid inadvertent intravenous doses of the local anaesthetic preparation.
Ref :-   Book : Martindale    Page : 2013   Edition : 37.  

►  Contraindication : Complete heart block, History of hypersensitivity reactions, Low plasma-cholinesterase concentration, Epidural or spinal block should not be used in patients with cerebrospinal diseases, Cardiogenic or hypovolaemic shock, or altered coagulation status, And where there is pyogenic infection of the skin at or adjacent to the injection site., Application of local anaesthetics to the skin for prolonged periods or to extensive areas should be avoided, Should not be instilled into the middle ear
Ref :-   Book : Martindale    Page : 2012   Edition : 37.  
  ►  Mechanism of Action :   Oxybuprocaine, a para-aminobenzoic acid ester, is a local anaesthetic act by preventing the generation and transmission of impulses along nerve fibres and at nerve endings; depolarisation and ion-exchange are inhibited.
Ref :-   Book : Martindale    Page : 2013,2029   Edition : 37.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- Betal leaf extract with Another pathway.  

  ►  Pathway with its reference as follows :-
  • --- ( Krishnakumar,, S. "Determination Of Local Anesthetic Action Of Betel Leaf Extract Alone And With Betel Nut Using Infiltration And Surface Anesthesia". Journal of Natural Remedise 1.1 (2001): 28-32. Print. )

  •   ►  URL --
  • file:///C:/Users/dr.%20lonch/Downloads/58-58-1-PB%20%281%29.pdf .

  • DIETARY Substance Interactions

    ​   ► This Medicine interact with :- NA

    ContraIndication DIETARY Substance

    ​   ► This Medicine contraindicate with :- KAVA KAVA with Maximise the effect of drug ..  

      ►  Reference :-
  • PDR for Herbal medicines. (2000) (4th ed.). U.S.

  •   ►  URL --

    ►   Route of Elimination :   NA

    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA